Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Senders, Max L.; Meerwaldt, Anu E.; Leent, Mandy M. T. van; Sánchez-Gaytán, Brenda L.; Voort, Jan C. van de; Toner, Yohana C.; Maier, Alexander; Klein, Emma D.; Sullivan, Nathaniel; Sofias, Alexandros Marios; Groenen, Hannah; Faries, Christopher; Oosterwijk, Roderick S.; Leeuwen, Esther M. van; Fay, François; Chepurko, Elena; Reiner, Thomas; Duivenvoorden, Raphaël; Zangi, Lior; Dijkhuizen, Rick M.; Hak, Sjoerd; Świrski, Filip K.; Nahrendorf, Matthias; Pérez-Medina, Carlos; Teunissen, Abraham J. P.; Fayad, Zahi A.; Calcagno, Claudia; Strijkers, Gustav J.; Mulder, Willem J. M.

doi:10.1038/s41565-020-0642-4

Cited by 50 publications

(48 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, little is known about how nanomaterial design parameters influence their in vivo propensity for uptake through specific endocytotic pathways (J. Zhao & Stenzel, 2018). A focused effort toward developing innovative nanomaterial imaging techniques is therefore essential (Pérez‐Medina et al, 2020; Schoormans et al, 2019; Senders et al, 2020; Teunissen et al, 2018; X. Zhu et al, 2015).…”

Section: Future Developmentsmentioning

confidence: 99%

See 1 more Smart Citation

Embracing nanomaterials' interactions with the innate immune system

Teunissen

Burnett

Prévot

et al. 2021

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

Immunotherapy has firmly established itself as a compelling avenue for treating disease. Although many clinically approved immunotherapeutics engage the adaptive immune system, therapeutically targeting the innate immune system remains much less explored. Nanomedicine offers a compelling opportunity for innate immune system engagement, as many nanomaterials inherently interact with myeloid cells (e.g., monocytes, macrophages, neutrophils, and dendritic cells) or can be functionalized to target their cell‐surface receptors. Here, we provide a perspective on exploiting nanomaterials for innate immune system regulation. We focus on specific nanomaterial design parameters, including size, form, rigidity, charge, and surface decoration. Furthermore, we examine the potential of high‐throughput screening and machine learning, while also providing recommendations for advancing the field. This article is categorized under: Nanotechnology Approaches to Biology > Nanoscale Systems in Biology Diagnostic Tools > In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease

show abstract

Section: Future Developmentsmentioning

confidence: 99%

“…Zhao & Stenzel, 2018). A focused effort toward developing innovative nanomaterial imaging techniques is therefore essential (Pérez-Medina et al, 2020;Schoormans et al, 2019;Senders et al, 2020;Teunissen et al, 2018;X. Zhu et al, 2015).…”

Section: Future Developmentsmentioning

confidence: 99%

Embracing nanomaterials' interactions with the innate immune system

Teunissen

Burnett

Prévot

et al. 2021

WIREs Nanomed Nanobiotechnol

Self Cite

View full text Add to dashboard Cite

show abstract

“…Targeting immune cells entails delivery to tissues enriched in immune cells, such as bone marrow, liver, lymph nodes, and spleen (Fig. 2 and Table 2) [33][34][35][36] . Research on the concept to achieve organ-specific targeting has enabled the development of a lipid NP platform that allowed for the targeted delivery of mRNA or gene editing in a tissue-specific manner [34,37] .…”

Section: Targeting Myeloid and Lymphoid Immune Cell-enriched Tissuesmentioning

confidence: 99%

“…Finally, it's worth mentioning that NPs have been used as tools for imaging-assisted immune cell tracking. HDL nanobiologics can be taken up by myeloid cells in the spleen and bone marrow, enabling the visualization of myeloid cell dynamics in atherosclerosis and myocardial infarction [33] . The functionalization of these NPs with different contrast agents allowed for the utilization of complementary imaging modalities, which together illustrated distinct immune cell migration patterns at different disease stages.…”

Section: Targeting Myeloid and Lymphoid Immune Cell-enriched Tissuesmentioning

confidence: 99%

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

Sofias

Combes

Koschmieder

et al. 2021

Drug Discovery Today

Self Cite

View full text Add to dashboard Cite

“…[4][5][6] Drug molecules can be loaded onto the surface of PFC NPs to improve solubility and pharmacokinetics and ultimately be released after active or passive targeting to the tumor site, thereby considerably enhancing drug accumulation within tumor cells. [7][8][9] Moreover, the core of PFCs can be detected by 19 F magnetic resonance imaging ( 19 F MRI), a non-invasive molecular imaging modality in precision medicine, allowing the tracking of drug biodistribution and monitoring of treatment e cacy [10][11][12][13][14][15] . Although these PFC-based drug delivery systems (DDS) have a number of advantages, problems such as limited delivery e ciency and poor penetration are still main obstacles for preclinical and clinical cancer treatment 16,17 .…”

Section: Introductionmentioning

confidence: 99%

19F MRI-guided Flexible Low-intensity Focused Ultrasound for Drug Delivery and Molecular Targeted Therapy

Yang

Sun

et al. 2021

Preprint

View full text Add to dashboard Cite

Non-site-specific, time-release and inefficient tumor penetration remain the major obstacles to the clinical efficacy of anticancer drugs. Novel strategies are therefore urgently needed for developing stimuli-responsive, local drug delivery systems that can increase drug penetration and accumulation at tumor sites. Here, we firstly describe an on-demand drug delivery system, AZD9291-PFCE nanoparticles (NPs) with 19F magnetic resonance imaging (19F MRI)-guided flexible low-intensity focused ultrasound (LIFU). Optimized AZD9291-PFCE NPs (size 73.9 ± 1.9 nm) reach high accumulation in non–small cell lung cancer (NSCLC) tumor tissue. Further, LIFU triggered drug release from AZD9291-PFCE NPs and specifically increased tumor vascular and tumor tissue permeability. Quantitative 19F MRI was used to measure NPs accumulation in tumors in real-time after LIFU irradiation and to monitor therapeutic efficacy. Thus, we present an innovative strategy to achieve on-demand release of AZD9291 and improve NSCLC EGFR-targeted therapy efficacy by integrating theranostic NPs and 19F MRI-guided LIFU.

show abstract

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Cited by 50 publications

References 27 publications

Embracing nanomaterials' interactions with the innate immune system

Embracing nanomaterials' interactions with the innate immune system

A paradigm shift in cancer nanomedicine: from traditional tumor targeting to leveraging the immune system

19F MRI-guided Flexible Low-intensity Focused Ultrasound for Drug Delivery and Molecular Targeted Therapy

Contact Info

Product

Resources

About