Probing physical properties of single amyloid fibrils using nanofluidic channels

Sasanian, Nima; Sharma, Rajhans; Lubart, Quentin; KK, Sriram; Ghaeidamini, Marziyeh; Dorfman, Kevin D.; Esbjörner, Elin K.; Westerlund, Fredrik

doi:10.1039/d3nr02740f

Nanoscale

2023

DOI: 10.1039/d3nr02740f

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Probing physical properties of single amyloid fibrils using nanofluidic channels

Nima Sasanian,

Rajhans Sharma,

Quentin Lubart

et al.

Abstract: A nanochannel-based method for single polymer persistence length analysis reveals differences in physical properties of amyloid fibrils and highlights in-sample variations.

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2024

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Nanofluidic Lab‐On‐A‐Chip Systems for Biosensing in Healthcare

Chong,

Shen,

Palomba

et al. 2024

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Biosensing plays a vital role in healthcare monitoring, disease detection, and treatment planning. In recent years, nanofluidic technology has been increasingly explored to be developed into lab‐on‐a‐chip biosensing systems. Given now the possibility of fabricating geometrically defined nanometric channels that are commensurate with the size of many biomolecules, nanofluidic‐based devices are likely to become a key technology for the analysis of various clinical biomarkers, including DNA (deoxyribonucleic acid) and proteins in liquid biopsies. This review summarizes the fundamentals and technological advances of nanofluidics from the purview of single‐molecule analysis, detection of low‐abundance molecules, and single‐cell analysis at the subcellular level. The extreme confinement and dominant surface charge effects in nanochannels provide unique advantages to nanofluidic devices for the manipulation and transport of target biomarkers. When coupled to a microfluidic network to facilitate sample introduction, integrated micro‐nanofluidic biosensing devices are proving to be more sensitive and specific in molecular analysis compared to conventional assays in many cases. Based on recent progress in nanofluidics and current clinical trends, the review concludes with a discussion of near‐term challenges and future directions for the development of nanofluidic‐based biosensing systems toward enabling a new wave of lab‐on‐a‐chip technology for personalized and preventive medicine.

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Nanofluidic Lab‐On‐A‐Chip Systems for Biosensing in Healthcare

Chong,

Shen,

Palomba

et al. 2024

Small

View full text Add to dashboard Cite

show abstract

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Probing physical properties of single amyloid fibrils using nanofluidic channels

Abstract: A nanochannel-based method for single polymer persistence length analysis reveals differences in physical properties of amyloid fibrils and highlights in-sample variations.

Cited by 1 publication

References 57 publications

Nanofluidic Lab‐On‐A‐Chip Systems for Biosensing in Healthcare

Nanofluidic Lab‐On‐A‐Chip Systems for Biosensing in Healthcare

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