2023
DOI: 10.1021/acschembio.3c00287
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Probing RNA–Small Molecule Interactions Using Biophysical and Computational Approaches

Amiu Shino,
Maina Otsu,
Koji Imai
et al.

Abstract: Interest in small molecules that target RNA is flourishing, and the expectation set on them to treat diseases with unmet medical needs is high. However, several challenges remain, including difficulties in selecting suitable tools and establishing workflows for their discovery. In this context, we optimized experimental and computational approaches that were previously employed for the protein targets. Here, we demonstrate that a fluorescence-based assay can be effectively used to screen small molecule librari… Show more

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References 46 publications
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