Probing striatal function in obsessive compulsive disorder using PET and a sequence learning task

Rauch, Scott L.; Savage, Cary R.; Alpert, Nathaniel M.; Dougherty, Donald M.; Kendrick, Adair; Curran, Tim; Brown, Halle D.; Manzo, Peter A.; Fischman, A. J.; Jenike, Michael A.

doi:10.1016/s1053-8119(96)80509-x

Cited by 63 publications

(79 citation statements)

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“…This finding is consistent with neurobiological models of OCD and with functional neuroimaging studies suggesting that dysfunction in the putamen contributes to the pathogenesis of OCD (Menzies et al, 2008a;Rauch et al, 1997). Furthermore, OCD symptom severity was associated with metabolic activity in the putamen , whereas decreased metabolic activity in the putamen after pharmacological treatment was associated with an improvement in cognitive function in OCD patients (Kang et al, 2003).…”

Section: Discussionsupporting

confidence: 86%

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Rotgé

Langbour

Guehl

et al. 2009

Neuropsychopharmacol

202

152

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Many voxel-based morphometry (VBM) studies have found abnormalities in gray matter density (GMD) in obsessive-compulsive disorder (OCD). Here, we performed a quantitative meta-analysis of VBM studies contrasting OCD patients with healthy controls (HC). A literature search identified 10 articles that included 343 OCD patients and 318 HC. Anatomic likelihood estimation meta-analyses were performed to assess GMD changes in OCD patients relative to HC. GMD was smaller in parieto-frontal cortical regions, including the supramarginal gyrus, the dorsolateral prefrontal cortex, and the orbitofrontal cortex, and greater in the basal ganglia (putamen) and the anterior prefrontal cortex in OCD patients relative to HC. No significant differences were found between children and adults. Our findings indicate differences in GMD in parieto-frontal areas and the basal ganglia between OCD patients and HC. We conclude that structural abnormalities within the prefrontal-basal ganglia network are involved in OCD pathophysiology.

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Section: Discussionsupporting

confidence: 86%

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Rotgé

Langbour

Guehl

et al. 2009

Neuropsychopharmacol

202

152

View full text Add to dashboard Cite

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“…More specifically, one theory holds that PCC functions in concert with the hippocampal formation to primarily subserve mnemonic and spatial functions (Sutherland and Hoesing 1993). Of note, implicit sequence learning studies of OCD indicate that patients may utilize the hippocampal system to compensate for cortico-striatal dysfunction (Rauch et al 1997(Rauch et al , 2000b. Along these lines, the current findings prompt the hypothesis that patients who exhibit greater resting activity within PCC are more likely to derive benefit from SRIs, which have been hypothesized to have their therapeutic action on OFC, anterior cingulate cortex, striatum, and/or hippocampus (Baxter et al 1992; Swedo et al 1992;Rauch et al 1998b;Blier and Bouchard 1994;Mansari et al 1995;Duman et al 1997).…”

Section: Discussionmentioning

confidence: 99%

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

Rauch

2002

Neuropsychopharmacology

161

108

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The purpose of this study was to identify neuroimaging predictors of medication response in contamination-related obsessive compulsive disorder (OCD). Prior studies of OCD had indicated that glucose metabolic rates within orbitofrontal cortex (OFC) were inversely correlated with subsequent response to serotonergic reuptake inhibitors (SRIs) and that glucose metabolic rates within posterior cingulate cortex (PCC) Functional imaging research has contributed substantially to contemporary neurocircuitry models of obsessive compulsive disorder (OCD) (Rauch 2000;Rauch and Baxter 1998;Saxena et al. 1998 PET Predictors of Fluxoamine Response in OCD 783OCD. These areas exhibit hyperactivity at rest that is accentuated during symptom provocation and attenuated following successful treatment.One promising clinical application of neuroimaging is to identify predictors of treatment response. Three prospective studies of OCD patients have already found that pre-treatment positron emission tomography (PET) measurements of cerebral metabolic rates within OFC significantly predict subsequent response to treatment with serotonergic reuptake inhibitors (SRIs) Saxena et al. 1999;Swedo et al. 1992). Specifically, lower pre-treatment rates of metabolism within OFC have consistently been associated with better subsequent responses to SRIs. Conversely, in one of these reports , higher cerebral metabolic rates within left OFC were associated with better responses to behavioral therapy.Recently, an initial study was conducted examining PET cerebral metabolic correlates as potential predictors of response to anterior cingulotomy in patients with OCD (Rauch et al. 2001b). Rauch and colleagues found that higher cerebral metabolic rates within posterior cingulate cortex (PCC) were associated with better subsequent response to cingulotomy. However, the cingulotomy study differed from previous studies of SRIs in that statistical parametric mapping rather than region of interest (ROI)-based methods of data analysis were used. Therefore, it remained unclear whether the unique findings regarding the PCC were indicative of: (1) the difference in treatment type (i.e., cingulotomy vs. SRIs); (2) the difference in data analytic methods (i.e., statistical parametric mapping vs. ROI-based); or (3) differences in the patient groups studied (i.e., severe treatment-refractory patients on medications vs. a conventional sample of patients with OCD, off medications).In the current study, we sought to build on the previous body of research in this area. Specifically, we sought to study PET predictors of SRI treatment response using statistical parametric mapping methods. Moreover, we employed a symptom provocation design, so that we could compare the profiles of PET predictors of treatment response during a provoked symptomatic state versus a neutral state. Thus, we tested the a priori hypotheses that lower rCBF within OFC and higher rCBF within PCC would be associated with better subsequent response to SRIs. Moreover, we were able to investigate whether ...

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“…However, it is not commonly seen as a critical component of sequence learning. In contrast, the striatum is known to participate in implicit sequence learning (Grafton et al, 1995;Rauch et al, 1995;Rauch et al, 1997) and specifically in the encoding of the temporal context set by the previous stimulus in the probabilistic SRT task . The finding that the strength of the functional connections between cuneus and striatum is increased during post-training REM sleep suggests the involvement of the basal ganglia in the off-line reprocessing of implicitly acquired high-order sequential information.…”

Section: Functional Relationships Between Rem Sleep and The Processinmentioning

confidence: 99%

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

et al. 2003

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Probing striatal function in obsessive compulsive disorder using PET and a sequence learning task

Cited by 63 publications

References 0 publications

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Gray Matter Alterations in Obsessive–Compulsive Disorder: An Anatomic Likelihood Estimation Meta-Analysis

Predictors of Fluvoxamine Response in Contamination-related Obsessive Compulsive Disorder A PET Symptom Provocation Study

Learned material content and acquisition level modulate cerebral reactivation during posttraining rapid-eye-movements sleep

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