Probing the Impact of Porosity on Swelling Kinetics of Hydrophilic Matrices

Asim, Muhammad S; Ghori, Muhammad Usman; Conway, Barbara R.

doi:10.5920/bjpharm.2017.16

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…Additionally, using FDM for tablet production can lead to products with seam-line issues and unsatisfactory seam-line issues, affecting both appearance and possibly performance [31]. Porosity is an important characteristic of hydrophilic matrices as higher overall porosity leads to rapid penetration of liquid molecules in comparison to lower overall porosity thus impacting the swelling behaviour [32]. In order to address these challenges, we proposed to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and dug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches.…”

Section: Introductionmentioning

confidence: 99%

Plasticiser-Free 3D Printed Hydrophilic Matrices: Quantitative 3D Surface Texture, Mechanical, Swelling, Erosion, Drug Release and Pharmacokinetic Studies

et al. 2019

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Hydroxypropyl methyl cellulose, HPMC, a hydrophilic polymer, is widely used for the development of extended release hydrophilic matrices and it is also considered as a good contender for the fabrication of 3D printing of matrix tablets. It is often combined with plasticisers to enable extrusion. The aim of the current project was to develop plasticizer-free 3D printed hydrophilic matrices using drug loaded filaments prepared via HME to achieve an in vitro (swelling, erosion and drug release) and in vivo (drug absorption) performance which is analogous to hydrophilic matrix tablets developed through conventional approaches. Additionally, the morphology of the printed tablets was studied using quantitative 3D surface texture studies and the porosity calculated. Filaments were produced successfully and used to produce matrix tablets with acceptable drug loading (95–105%), mechanical and surface texture properties regardless of the employed HPMC grade. The viscosity of HPMC had a discernible impact on the swelling, erosion, HPMC dissolution, drug release and pharmacokinetic findings. The highest viscosity grade (K100M) results in higher degree of swelling, decreased HPMC dissolution, low matrix erosion, decreased drug release and extended drug absorption profile. Overall, this study demonstrated that the drug loaded (glipizide) filaments and matrix tablets of medium to high viscosity grades of HPMC, without the aid of plasticisers, can be successfully prepared. Furthermore, the in vitro and in vivo studies have revealed the successful fabrication of extended release matrices.

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Section: Introductionmentioning

confidence: 99%