Probing the mechanical properties of ORF3a protein, a transmembrane channel of SARS-CoV-2 virus: Molecular dynamics study

Maymand, Vahid Mahmoudi; Bavi, Omid; Karami, Abbas

doi:10.1016/j.chemphys.2023.111859

Cited by 3 publications

(1 citation statement)

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“…Apart from its role in viral replication and assembly, orf3a is implicated in host cell penetration and the inactivation of the host immune system 72 , further contributing to the pathogenesis of SARS-CoV-2 infection. Due to its significance in the virus life cycle and its potential impact on disease progression, the orf3a protein has become a major target for vaccine development 73 . The data analysis reveals that This figure presents a summary of common mutations with harmful effects found in structural and non-structural proteins of SARS-CoV-2, as reported in various countries.…”

Section: Orf3amentioning

confidence: 99%

Bridging Computational Predictions and Empirical Data: Insights into SARS-CoV-2 Mutational Impacts and Evolution

Shaukat,

Nguyen,

Hsu

et al. 2024

Preprint

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The emergence of SARS-CoV-2 has unleashed a global health crisis, demanding advanced research into its genomic mutations and their consequences. Our study combines computational models and empirical validation to predict the effects of these mutations, aiming to understand their impact on the virus's behaviour, including its transmissibility and immune escape mechanisms. Utilising advanced prediction tools, we analysed mutations across the virus's genome, focusing on changes to both structural and non-structural proteins. This approach identified key mutations likely to influence protein functionality and the virus's evolution. Our findings, integrating computational predictions with real-world data, offer insights into SARS-CoV-2's evolutionary path and its implications for developing vaccines and therapies. We highlight the necessity of ongoing genomic surveillance and the combined use of computational and empirical methods to stay ahead of viral mutations. This study not only deepens our understanding of SARS-CoV-2 but also lays groundwork for future research on viral evolution and pandemic response strategies, emphasizing our approach's potential to inform public health decisions and research priorities.

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Section: Orf3amentioning

confidence: 99%