Probing the molecular basis for ligand-selective recognition in molecularly imprinted polymers selective for the local anaesthetic bupivacaine

Karlsson, Jesper G; Andersson, Lars I.; Nicholls, Ian A.

doi:10.1016/s0003-2670(00)01182-x

Cited by 104 publications

(89 citation statements)

References 14 publications

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“…Such behaviour is in accordance with results obtained from the binding experiments (Table 3). This observation supports a model of retention mechanism which assumes that the selective sites have stronger interaction with the drug than the non-selective sites [23].…”

Section: Mip-3supporting

confidence: 84%

Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids

et al. 2007

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Abstract:The aim of this work was to investigate the possibility of employing Molecularly Imprinted Polymers (MIPs) as a controlled release device for 5-fluorouracil (5-FU) in biological fluids, especially gastrointestinal ones, compared to Non Imprinted Polymers (NIPs). MIPs were synthesized using methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as crosslinking agent. The capacity of the polymer to recognize and to bind the template selectively in both organic and aqueous media was evaluated. An in vitro release study was performed both in gastrointestinal and in plasma simulating fluids. The imprinted polymers bound much more 5-Fu than the corresponding non-imprinted ones and showed a controlled/sustained drug release, with MIPs release rate being indeed much more sustained than that obtained from NIPs. These polymers represent a potential valid system for drug delivery and this study indicates that the selective binding characteristic of molecularly imprinted polymers is promising for the preparation of novel controlled release drug dosage form.

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Section: Mip-3supporting

confidence: 84%

Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids

et al. 2007

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“…The mixed-mode binding offered by a methacrylic acidethylene glycol co-polymer in aqueus media (Karlsson et al, 2001(Karlsson et al, , 2004Rosengren et al, 2005) was also probed. Polymers of this general type have recently been used in conjunction with molecular imprinting protocols (Alexander et al, 2006) for generating materials with warfarin-selective binding (Karlsson et al, submitted).…”

Section: Resultsmentioning

confidence: 99%

Warfarin: an environment‐dependent switchable molecular probe

Nicholls

Karlsson

Rosengren

et al. 2010

J of Molecular Recognition

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The complex nature of the structure of the anticoagulant warfarin is reflected in the diversity of binding modes observed in warfarin-protein recognition systems. A series of theoretical, 1 H-NMR and steady state and time resolved fluorescence spectroscopic studies, have been used to establish correlations between the molecular environment provided by various solvent systems and the relative concentrations of the various members of warfarin's ensemble of isomers. A consequence of these observations is that the judicious choice of solvent system or molecular environment of warfarin allows for manipulation of the position of the equilibrium between isomeric structures such as the hemiacetal and open phenol-keto forms, the latter even possible in a deprotonated form, where in each case unique spectroscopic properties are exhibited by the respective structures. Collectively, warfarin's capacity to adapt its structure as a function of environment in conjunction with the fluorescence behaviours of the various isomers together provide an environment-dependent molecular switch with reporter properties, which allows for the simultaneous detection of warfarin in different states with lifetimes spanning the range < 0.10-5.5 ns. These characteristics are here used to examine warfarin binding domains in a series of materials (solvents, protein, inorganic matrix and synthetic polymer). Moreover, these studies demonstrate the potential for using warfarin, or other switchable analogues thereof, as a tool for studying molecular level characteristics, for example local dielectricity.

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“…746 Supercritical CO 2 has been proposed as an alternative porogen for MIP production. 888,889 The use of water in non-polar media has been shown to increase hydrophobic interactions; 890,891 conversely ionic interactions are enhanced through the presence of organic modifiers in aqueous porogens 752,892 between template and functional monomers. …”

Section: 826mentioning

confidence: 99%

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

Andersson²,

et al. 2006

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Over 1450 references to original papers, reviews and monographs have herein been collected to document the development of molecular imprinting science and technology from the serendipitous discovery of Polyakov in 1931 to recent attempts to implement and understand the principles underlying the technique and its use in a range of application areas. In the presentation of the assembled references, a section presenting reviews and monographs covering the area is followed by papers dealing with fundamental aspects of molecular imprinting and the development of novel polymer formats. Thereafter, literature describing attempts to apply these polymeric materials to a range of application areas is presented.

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Probing the molecular basis for ligand-selective recognition in molecularly imprinted polymers selective for the local anaesthetic bupivacaine

Cited by 104 publications

References 14 publications

Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids

Molecularly Imprinted Polymers for 5-Fluorouracil Release in Biological Fluids

Warfarin: an environment‐dependent switchable molecular probe

Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003

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