Probing the molecular mechanism of aggressive infection by antimony resistant Leishmania donovani

Short-Course Treatment With Imipramine Entrapped in Squalene Liposomes Results in Sterile Cure of Experimental Visceral Leishmaniasis Induced by Antimony Resistant Leishmania donovani With Increased Efficacy

“…Mukherjee et al, 2012). Like IL-10, this higher frequency was also observed in case of TGF-b production in Sb R LD infected mice and corroborates with a previous report (Guha et al, 2014) (Mukherjee et al, 2020). TGF-b production also decreased significantly upon liposomal-imipramine treatment ( Figure 3B, v).…”

Highlighting the interplay of microRNAs from Leishmania parasites and infected-host cells

“…Considering that miRNAs are involved in the control of cytokines expression (Garavelli et al, 2018), the alteration of miRNA profile in the host cell could be an effective strategy to ensure infection or drug resistance by pathogens. Accordingly, targeting miRNA pathway might be a novel strategy to control infection caused by pathogens such as LD R parasites (Mukherjee et al, 2020). The clinical manifestations of L. donovani infection are related to the critical balance of pro-and antiinflammatory cytokines which is obtained through the miRNA-mediated regulation and by targeting the miRNA modulators, HuR and protein phosphatase 2A (PP2A) (Goswami et al, 2020).…”

Identification of 3-Methoxycarpachromene and Masticadienonic Acid as New Target Inhibitors against Trypanothione Reductase from Leishmania Infantum Using Molecular Docking and ADMET Prediction

“…However, lack of potential alternatives has forced patients to be dependent on these chemotherapeutic drugs [ 10 ]. Several scientific reports declared a therapeutic failure linked to the emergence of drug-resistant strains [ 11 , 12 , 13 , 14 ].…”