There is a very long tradition of studying nuclear structure and reactions at the Legnaro National Laboratories (LNL) of the Istituto Nazionale di Fisica Nucleare (Italian Institute of Nuclear Physics). The wide expertise acquired in building and running large germanium arrays has made the laboratories one of the most advanced research centers in γ-ray spectroscopy. The 'gamma group' has been deeply involved in all the national and international developments of the last 20 years and is currently one of the major contributors to the AGATA project, the first (together with its American counterpart GRETINA) γ-detector array based on γ-ray tracking. This line of research is expected to be strongly boosted by the coming into operation of the SPES radioactive ion beam project, currently under construction at LNL. In this report, written on the occasion of the 40th anniversary of the Nobel prize awarded to Aage Bohr, Ben R Mottelson and Leo Rainwater and particularly focused on the physics of nuclear structure, we intend to summarize the different lines ofresearch that have guided nuclear structure and reaction research at LNL in the last decades. The results achieved have paved the way for the present SPES facility, a new laboratoriesinfrastructure producing and accelerating radioactive ion beams of fission fragments and other isotopes. Keywords: nuclear physics, nuclear structure, nuclear reactions, heavy-ion accelerator, radioactive ion beam facility research infrastructure providing beam time and use of detectors to outside researchers. The research program is conducted by more then 500 scientists originating from several countries, technical staff and students. The main focus concerns research in nuclear physics, based on accelerated heavy-ion beams, and in applications using nuclear physics technologies. The laboratories is also involved in research in basic interactions, gravitational waves, accelerator physics, energetics, material science, biology, medicine and the effects of radiation on materials. It also contributes to numerous national and international projects hosted in other universities