2013
DOI: 10.1152/japplphysiol.00092.2013
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Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging

Abstract: Although some central aspects of pulmonary function (ventilation and perfusion) are known to be heterogeneous, the distribution of diffusive gas exchange remains poorly characterized. A solution is offered by hyperpolarized 129Xe magnetic resonance (MR) imaging, because this gas can be separately detected in the lung's air spaces and dissolved in its tissues. Early dissolved-phase 129Xe images exhibited intensity gradients that favored the dependent lung. To quantitatively corroborate this finding, we develope… Show more

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Cited by 57 publications
(64 citation statements)
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“…129 Xe gas transfer MRI was acquired on a 1.5T scanner (GE EXCITE 15M4), using an interleaved radial acquisition of gas- and dissolved-phase images during a 15-s breath-hold 30 . Images were acquired at an echo time (TE 90 ≈ 0.9 ms) that allows the barrier and RBC signals to be separated by the 1-point Dixon method 23 .…”
Section: Methodsmentioning
confidence: 99%
“…129 Xe gas transfer MRI was acquired on a 1.5T scanner (GE EXCITE 15M4), using an interleaved radial acquisition of gas- and dissolved-phase images during a 15-s breath-hold 30 . Images were acquired at an echo time (TE 90 ≈ 0.9 ms) that allows the barrier and RBC signals to be separated by the 1-point Dixon method 23 .…”
Section: Methodsmentioning
confidence: 99%
“…All the major types of contrast-weighting demonstrated using 3 He MRI have now been replicated robustly with enriched 129 Xe [27, 28]. Unlike 3 He, 129 Xe diffuses from the gas phase into the tissues and blood, where chemical shifts associated with the local spin environment can be imaged directly to enable quantitative modeling of gas exchange [2931]. More recently, the solubility of HP 129 Xe gas into the plasma and red blood cells has also been exploited for brain imaging, enabling characteristic measures of perfusion and T 1 relaxation in different brain compartments [32].…”
Section: Physical and Biological Properties Of Polarized Agentsmentioning
confidence: 99%
“…Quantitative measures such as “saturation transfer time” allow the kinetics of 129 Xe recovery to be modeled. These more advanced methods can provide direct [2931, 151] or indirect [147, 152] estimates of average septal wall thickness and alveolar surface area-to-volume ratio [147, 148, 153]. Both single-voxel [153, 154] and spectroscopic imaging methods [30, 31] are feasible.…”
Section: Deriving Functional Measures From Hyperpolarized Agentsmentioning
confidence: 99%
“…[68][69][70][71] Finally, because of the slight solubility of 129 Xe in tissues and blood, dissolved-phase imaging of hyperpolarized 129 Xe can be used to probe gas exchange and perfusion dynamics. [72][73][74][75][76] In general, all of these techniques are possible with a single breath-hold (<20 s, typically much shorter) of hyperpolarized gas. More in-depth reviews of the translational applications of hyperpolarized gas-MRI, 77 as well as applications specific to 3 He MRI 78 and 129 Xe MRI, 79 can be found elsewhere.…”
Section: Hyperpolarized-gas Mrimentioning
confidence: 99%