Probing The Relation Between Vitamin D Deficiency and Progression of Medial Femoro-tibial Osteoarthitis of the Knee

Bassiouni, Hassan; Aly, Hany; Zaky, Khaled; Abaza, Nouran; Bardin, Thomas

doi:10.2174/1573397112666160404124532

Cited by 23 publications

(14 citation statements)

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“…The present study revealed significant decrease in the levels of Vitamin D in study subjects (p<0.05). Our results were corroborated with Bassiouni et al (15) ,Veronese et al (16) and Jansen and Haddad (17) found that serum 25(OH)D levels were significantly decreased in the patients with knee OA and noted that medial meniscal deterioration was seen in patients with low vitamin D levels.…”

Section: Discussion:-supporting

confidence: 91%

Role of Shatavari in Management of Early Osteoarthritis.

SKRai¹

2019

IJAR

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Section: Discussion:-supporting

confidence: 91%

Role of Shatavari in Management of Early Osteoarthritis.

SKRai¹

2019

IJAR

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“…Vitamin D reduced pain and improved function in knee OA patients. While deficiency in endogenous vitamin D, reflected by low levels of circulating 25 OH vitamin D, was associated with the onset and progression of knee OA [38], maybe through an increased frequency of medial meniscus lesions [39], results of individual RCTs were inconclusive [40][41][42][43]. Their outcomes varied from a non-significant trend for symptom reduction [40][41][42] to a small but statistically significant benefit on pain and function after 12 months of administration [43].…”

Section: Discussionmentioning

confidence: 99%

Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon

Beaudart

Lengelé

Leclercq

et al. 2020

Drugs

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Introduction Several pharmacological treatments aiming at a better symptomatic control of osteoarthritis (OA) are used in daily practice but their efficacy is often disputed. The purpose of this network meta-analysis (NMA) is to assess the efficacy on pain and function of the drugs that are most widely prescribed against knee OA. Methods Medline, Scopus, and Cochrane database of systematic reviews were searched for randomized controlled trials published up to August 2019 and assessing the efficacy of knee OA treatments using a 6-month time horizon. Pain and function changes from baseline were the primary outcomes. A Bayesian network meta-analysis was run and standardized mean differences (SMDs) with 95% credibility intervals (95% CrIs) were calculated. Results 9697 references were identified and 80 RCTs were concordant with our inclusion criteria (79 studies involving 15,609 individuals reported pain outcomes and 55 studies involving 13,655 individuals reported function outcomes). A significant decrease in pain was observed for the intra-articular (IA) combination of hyaluronic acid (HA) and triamcinolone (SMD − 0.49, 95% CrI − 0.78; − 0.19), vitamin D (SMD − 0.31, 95% CrI − 0.56; − 0.06), IA HA (SMD − 0.29, 95% CrI − 0.40; − 0.17), prescription-grade crystalline glucosamine sulfate (pCGS) (SMD − 0.29, 95% CrI − 0.58; − 0.004), and prescription-grade chondroitin sulfate (pCS) (SMD − 0.26, 95% CrI − 0.44; − 0.08). Significant improvements in physical function were found with pCGS (SMD − 0.44, 95% CrI − 0.66; − 0.21), vitamin D (SMD − 0.30, 95% CrIs − 0.49; − 0.11) and IA HA (SMD − 0.21, 95% CrIs − 0.31; − 0.11). Conclusion Six months of treatment with IA HA, pCGS, pCS, vitamin D and the combination of IA HA and triamcinolone improve pain and/or physical function in patients suffering from knee OA.

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“…It has been shown that patients with OA have decreased vitamin D serum levels ( Table 2 ). Bassiouni et al 9 and Veronese et al 49 both found that serum 25(OH)D levels were significantly decreased in the patients with knee OA and noted that medial meniscal deterioration was seen in patients with low vitamin D levels. In a cross-sectional study, Jansen and Haddad 24 showed that in elderly patients with advanced knee OA, there was a high prevalence of vitamin D deficiency.…”

Section: Vitamin D and Osteoarthritismentioning

confidence: 99%

Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis

Garfinkel

Dilisio

Agrawal

2017

Orthopaedic Journal of Sports Medicine

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Background:Osteoarthritis (OA) currently affects 10% of the American population. There has been a recent push to determine exactly what causes OA and how it can be treated most effectively. Serum vitamin D levels have been associated with OA and may have an effect on articular cartilage remodeling.Purpose:To critically review the published research on the effect of vitamin D on articular cartilage and the development of OA as well as on the mechanism behind cartilage regeneration and degeneration.Study Design:Review.Methods:A systematic search of PubMed and the Web of Science was performed for relevant studies published in the English language through April 30, 2016, using the terms vitamin D, articular cartilage, and osteoarthritis.Results:On a molecular level, 1α,25(OH)2D3, the activated form of vitamin D, plays a role in articular cartilage degeneration. Vitamin D binds to vitamin D receptors, triggering a signaling cascade that leads to chondrocyte hypertrophy. In clinical trials, vitamin D deficiency poses a risk factor for OA, and those with decreased cartilage thickness are more likely to be vitamin D–insufficient.Conclusion:The role of vitamin D supplementation in the treatment or prevention of OA remains uncertain. More research is needed to reconcile these conflicting findings.

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Probing The Relation Between Vitamin D Deficiency and Progression of Medial Femoro-tibial Osteoarthitis of the Knee

Abstract: 25 (OH) D levels were significantly decreased in knee OA patients. Significant deterioration of the medial menisci was observed in OA patients with 25 (OH)D levels <10 ng/ml suggesting that Vit D deficiency may play a role in the progression of medial femoro-tibial OA.

Cited by 23 publications

References 0 publications

Role of Shatavari in Management of Early Osteoarthritis.

Role of Shatavari in Management of Early Osteoarthritis.

Symptomatic Efficacy of Pharmacological Treatments for Knee Osteoarthritis: A Systematic Review and a Network Meta-Analysis with a 6-Month Time Horizon

Vitamin D and Its Effects on Articular Cartilage and Osteoarthritis

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