2022
DOI: 10.21203/rs.3.rs-1518166/v2
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Probiotic ameliorating effects of altered GABA/glutamate signaling in a rodent model of autism

Abstract: Background: Autism spectrum disorders (ASDs) comprise a heterogeneous group of pathological conditions, mainly of genetic origin, characterized by stereotyped behavior, marked impairment in verbal and nonverbal communication, social skills, and cognition. Excitatory/inhibitory (E/I) imbalances have been recorded as an etiological mechanism of ASD. Furthermore, GABA, the main inhibitory neurotransmitter in adult life is known to be much lower in both patients and rodent models of ASD. Methods: In the present … Show more

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