Probiotic Applications of Bacillus subtilis

Abstract

Probiotics are defined as live microorganisms that confer health advantages to their hosts. Some probiotics exhibit limitations, including susceptibility to temperature fluctuations, gastric acidity, and harsh conditions. This has led to exploring probiotics with higher intrinsic resistance and stability in harsh conditions. Bacillus subtilis has received attention due to its inherent probiotic properties, high resistance to harsh conditions, and ability to form spores. Significant progress has been made in understanding the probiotic potential of B. subtilis, uncovering various mechanisms of action. On the other hand, postbiotics secreted by B. subtilis have become an attractive field of interest for scientists. Numerous studies have validated the efficacy of B. subtilis as a dietary supplement for poultry and aquaculture. Furthermore, the Food and Drug Administration (FDA) has recognized B. subtilis as safe. These advantageous properties position B. subtilis as a highly promising probiotic for various applications.