2024
DOI: 10.3390/ijms25010561
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Probiotic Bacillus licheniformis ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis

Dan Jia,
Yingying Li,
Yingjie Wang
et al.

Abstract: Despite Bacillus species having been extensively utilized in the food industry and biocontrol as part of probiotic preparations, limited knowledge exists regarding their impact on intestinal disorders. In this study, we investigated the effect of Bacillus licheniformis ZW3 (ZW3), a potential probiotic isolated from camel feces, on dextran sulfate sodium (DSS)-induced colitis. The results showed ZW3 partially mitigated body weight loss, disease activity index (DAI), colon shortening, and suppressed immune respo… Show more

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Cited by 6 publications
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“…Considering the role of probiotics as an emerging treatment for various diseases, several studies have been conducted to evidence their role in the treatment of various diseases specifically against enteropathogenic microorganisms [43]. In the treatment of enteropathogenic diseases, probiotics help maintain gut homeostasis [44,45] and gut barrier integrity [46], enhance nutrient digestion [47], and defend against pathogens by modulating immune responses [48]. Building upon these probiotic mechanisms, the analyses of the microbiome, transcriptome, and metabolome were conducted to investigate the beneficial effects of probiotic L. acidophilus in response to the detrimental effects of Salmonella infection.…”
Section: Discussionmentioning
confidence: 99%
“…Considering the role of probiotics as an emerging treatment for various diseases, several studies have been conducted to evidence their role in the treatment of various diseases specifically against enteropathogenic microorganisms [43]. In the treatment of enteropathogenic diseases, probiotics help maintain gut homeostasis [44,45] and gut barrier integrity [46], enhance nutrient digestion [47], and defend against pathogens by modulating immune responses [48]. Building upon these probiotic mechanisms, the analyses of the microbiome, transcriptome, and metabolome were conducted to investigate the beneficial effects of probiotic L. acidophilus in response to the detrimental effects of Salmonella infection.…”
Section: Discussionmentioning
confidence: 99%