2021
DOI: 10.1101/2021.03.03.433775
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Probiotic bacteria and bile acid profile are modulated by prebiotic diet and associate with facilitated diurnal clock/sleep realignment after chronic disruption of rhythms

Abstract: Chronic disruption of rhythms (CDR) impacts sleep and can result in circadian misalignment of physiological systems, which in turn is associated with increased disease risk. Exposure to repeated or severe stressors also disturbs sleep and diurnal rhythms. Prebiotic nutrients produce favorable changes in gut microbial ecology, the gut metabolome, and reduce several negative impacts of acute severe stressor exposure, including disturbed sleep, core body temperature rhythmicity, and gut microbial dysbiosis. This … Show more

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“…Our results also identified Ruminiclostridium5 as a risk for promoting hypothyroidism. Although limited information is available on Ruminiclostridium5, its increased abundance is linked to systemic inflammation and a negative correlation with secondary and conjugated bile acids (55,56). Consistent with prior studies, phylum Verrucomicrobia emerged as a protective factor against hypothyroidism in our result.…”
Section: Discussionsupporting
confidence: 91%
“…Our results also identified Ruminiclostridium5 as a risk for promoting hypothyroidism. Although limited information is available on Ruminiclostridium5, its increased abundance is linked to systemic inflammation and a negative correlation with secondary and conjugated bile acids (55,56). Consistent with prior studies, phylum Verrucomicrobia emerged as a protective factor against hypothyroidism in our result.…”
Section: Discussionsupporting
confidence: 91%