Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

Ma, Teng; Jin, Hao; Kwok, Lai‐Yu; Sun, Zhihong; Liong, Min‐Tze; Zhang, Heping

doi:10.1016/j.ynstr.2021.100294

Cited by 86 publications

(75 citation statements)

References 69 publications

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“…Clostridium_sensu_stricto_1, Alistipes, Lachnoclostridium, and Desulfovibrio are opportunistic pathogens that may cause infection, aggravate inflammation, or worsen clinical conditions (25,(37)(38)(39)(40)(41). The exact functions of Blautia, Lachnospira, Fusicatenibacter, Dubosiella, and Agathobacter are not clear, but some researchers think they may have some relationship with some diseases (32,(42)(43)(44)(45)(46)(47)(48). Faecalibacterium is beneficial to humans (49,50).…”

Section: Discussionmentioning

confidence: 99%

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

et al. 2021

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Introduction: Asphyxia is an emergent condition in neonates that may influence the function of the nervous system. Research has shown that intestinal microbiota is very important for neurodevelopment. Studies regarding the association between gut microbiota and neurodevelopment outcome in asphyxiated newborns remain scarce.Objective: To study the microbial characteristics of asphyxiated neonates within 1 week of life and to investigate their relationship with neural development at 6 months.Methods: The feces produced on days 1, 3, and 5, and the clinical data of full-term neonates with asphyxia and without asphyxia, delivered from March 2019 to October 2020 at Peking University First Hospital, were collected. We used 16S ribosomal deoxyribonucleic acid amplicon sequencing to detect the intestinal microbiota of asphyxiated neonates and neonates in the control group. We followed up asphyxiated neonates for 6 months and used the Ages and Stages Questionnaires-3 (ASQ-3) to evaluate their development.Results: A total of 45 neonates were enrolled in the study group and 32 were enrolled in the control group. On day 1, the diversity and richness of the microflora of the study group were more than those of the control group. Non-metric multidimensional scaling analysis showed significant differences in the microbiota of the two groups on days 1, 3, and 5. At the phylum level, the main microflora of the two groups were not different. At the genus level, the study group had increased relative abundance of Clostridium_sensu_stricto_1, Lachnoclostridium, Fusicatenibacter, etc. on day 1. On day 3, the relative abundance of Clostridium_sensu_stricto_1, Fusicatenibacter, etc. was still greater than that of the control group, and the relative abundance of Staphylococcus was less than that of the control group. On day 5, the relative abundance of Clostridium_sensu_stricto_1 and Lachnoclostridium was still higher than that of the control group, and the relative abundance of Dubosiella in the study group was significantly increased. At the species level, on day 3, the relative abundance of Staphylococcus caprae in the study group was less than that in the control group. Linear discriminant analysis effect size showed that the microbiota of the study group mainly consisted of Lachnospiraceae and Clostridia on day 1 and Clostridia on day 3. In the control group, Staphylococcus was the dominant bacterium on day 3. Neonates in the study group were followed up for 6 months, and the communication score of ASQ-3 was negatively correlated with the relative abundance of Lachnospiraceae and Clostridia on day 1.Conclusion: The diversity and richness of the microbiota of asphyxiated neonates on the first day of life were significantly increased and mainly consisted of pathogenic flora. Lachnospiraceae and Clostridia found in neonates with asphyxia on day 1 of life may be related to neural development at 6 months.

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Section: Discussionmentioning

confidence: 99%

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

et al. 2021

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“…Probiotics that promote the balance of gut microbiota play an important role in the treatment of IBD [25]. It is reported that the intervention of probiotics improved the gut microbiota and has an effective protective effect on the immune health of the host [26,27]. The results of animal and clinical studies showed that products containing probiotics or prebiotics improved IBD by regulating proinflammatory signaling pathways and downregulating proinflammatory cytokines [7].…”

Section: Interaction Between Bifidobacterium Longum and The Hostmentioning

confidence: 99%

Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

Yao

Zhao

Wang

et al. 2021

Journal of Immunology Research

129

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The prevalence of inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn’s disease (CD), increases gradually worldwide in the past decades. IBD is generally associated with the change of the immune system and gut microbiota, and the conventional treatments usually result in some side effects. Bifidobacterium longum, as colonizing bacteria in the intestine, has been demonstrated to be capable of relieving colitis in mice and can be employed as an alternative or auxiliary way for treating IBD. Here, the mechanisms of the Bifidobacterium longum in the treatment of IBD were summarized based on previous cell and animal studies and clinical trials testing bacterial therapies. This review will be served as a basis for future research on IBD treatment.

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“…Moreover, probiotics are able to sense and regulate the action of secondary metabolites (e.g., bacteriocins, enzymes, and exopolysaccharides). Probiotic rich diets, adjunctive probiotic supplementation, and the prescription of personalized probiotics based on previous microbial analysis (targeted gut microbiota modulation) are linked with the prevention and potential treatment of several severe disorders, such as inflammatory bowel diseases, colorectal cancer, obesity, diabetes, and cardiovascular diseases as well as food allergies, depression, and brain function [17,[46][47][48][49][50][51][52][53][54]. As the worldwide incidence of food allergies is increasing, there is an urgent need for well-controlled studies that demonstrate the positive outcomes of probiotics.…”

Section: Modulation By Probioticsmentioning

confidence: 99%

Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

Kvaková

Bertková

Štofilová

et al. 2021

Foods

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Growing interest in the development of innovative functional products as ideal carriers for synbiotics, e.g., nutrient bars, yogurt, chocolate, juice, ice cream, and cheese, to ensure the daily intake of probiotics and prebiotics, which are needed to maintain a healthy gut microbiota and overall well-being, is undeniable and inevitable. This review focuses on the modern approaches that are currently being developed to modulate the gut microbiota, with an emphasis on the health benefits mediated by co-encapsulated synbiotics and immobilized probiotics. The impact of processing, storage, and simulated gastrointestinal conditions on the viability and bioactivity of probiotics together with prebiotics such as omega-3 polyunsaturated fatty acids, phytochemicals, and dietary fibers using various delivery systems are considered. Despite the proven biological properties of synbiotics, research in this area needs to be focused on the proper selection of probiotic strains, their prebiotic counterparts, and delivery systems to avoid suppression of their synergistic or complementary effect on human health. Future directions should lead to the development of functional food products containing stable synbiotics tailored for different age groups or specifically designed to fulfill the needs of adjuvant therapy.

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Probiotic consumption relieved human stress and anxiety symptoms possibly via modulating the neuroactive potential of the gut microbiota

Cited by 86 publications

References 69 publications

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

Evolution of Intestinal Microbiota of Asphyxiated Neonates Within 1 Week and Its Relationship With Neural Development at 6 Months

Bifidobacterium Longum: Protection against Inflammatory Bowel Disease

Co-Encapsulated Synbiotics and Immobilized Probiotics in Human Health and Gut Microbiota Modulation

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