Probiotic effect in preterm neonates with sepsis - A systematic review protocol

Abstract

Background: The microbiota in the intestine is made up of trillions of living bacteria that coexist with the host. Administration of antibiotics during neonatal infection causes depletion of gut flora resulting in gut dysbiosis. Over the last few decades, probiotics have been created and promoted as microbiota management agents to enrich gut flora. Probiotics decrease the overgrowth of pathogenic bacteria in the gut of preterm neonates, reducing the frequency of nosocomial infections in the Neonatal Intensive Care Unit (NICUs). Methods: The systematic review will include randomized control trials (RCTs) of premier neonates with sepsis. Studies will be retrieved from global databases like Cochrane CENTRAL, CINAHL Plus via EBSCO host, MEDLINE via PubMed, EMBASE, SCOPUS, Ovid, Web of Science, ProQuest Medical Library, Microsoft academic, and DOAJ by utilizing database-specific keywords. Screening, data extraction, and critical appraisal of included research will be carried out separately by two review writers. Findings will be reported in accordance with the PRISMS-P 2020 guidelines. Conclusions: The findings of this systematic review will help to translate the evidence-based information needed to encourage the implementation of potential research output in the field of neonatal intensive care, guide best clinical practise, assist policy making and implementation to prevent gut dysbiosis in neonates with sepsis by summarising and communicating the evidence on the topic. PROSPERO registration number: This systematic review protocol has been registered in PROSPERO (Prospective Register of Systematic Reviews) on 10th March 2022. The registration number is CRD42022315980.

Probiotic effect in preterm neonates with sepsis - A systematic review protocol

“…This protocol follows the recommendations of the Preferred Reporting Items for Systematic Review and Meta-Analyses of Protocols (PRISMA-P) 2015. 40 The Participants, Interventions, Comparators and Outcomes elements used for the systematic review are listed in Table 1.…”

“…A comprehensive search would be conducted in global databases like Cochrane CENTRAL, CINAHL Plus via EBSCO host, MEDLINE via PubMed, EMBASE, SCOPUS, Ovid, Web of Science and ProQuest Medical Library by utilizing the stated search keywords: "Premature neonates", "Preterm birth", "Very low birth weight", "Low birth weight", Preterm, "Preterm infants", "extremely low birth weight", "Neonates", "Neonatal infection", Infection*, "Late-onset sepsis", "Early-onset sepsis", Sepsis, "Neonatal period", "intestinal infection", "Nosocomial infection", septicaemia, Bacteraemia, "septic shock", probiotic*, "Probiotic supplement", Lactobacilli, Lactobacillus, Bifidobacterium, "Lactic acid bacteria", Bacillus OR "Probiotic therapy", "Randomized Controlled Trial", and "Nonrandomized controlled trial" (Extended data 38 ). Term neonates and preterm neonates without sepsis.…”

“…Figshare: Supplementary file 2. https://doi.org/10.6084/m9.figshare.19839964. 39 This project contains the following extended data:…”

“…Figshare: PRISMA-P checklist for 'Probiotic effect in preterm neonates with sepsis -A systematic review protocol', https://doi.org/10.6084/m9.figshare.19839241. 40 Data are available under the terms of the Creative Commons Attribution 4.0 International license (CC-BY 4.0).…”