2020
DOI: 10.3390/microorganisms8091272
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Probiotic Effects on Multispecies Biofilm Composition, Architecture, and Caries Activity In Vitro

Abstract: While probiotics have been tested for their anti-caries effect in vitro and also clinically, there is a lack of understanding of their effects on complex dental biofilms. We assessed two probiotics, Lactobacillus reuteri and Streptococcus oligofermentans, on a continuous-cultured model containing Streptococcus mutans, Lactobacillus rhamnosus and Actinomyces naeslundii. Cariogenic biofilms were grown on bovine enamel specimens and daily challenged with L. reuteri or S. oligofermentans whole culture (LC/SC) or c… Show more

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Cited by 14 publications
(10 citation statements)
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“…Although Lactobacillus and Bifidobacterium are usual probiotics of breast milk, they formed only 0.4% and 1.7% of isolated probiotics. This was also shown by Chen et al (2020), who have even recorded their absence in some milk samples [ 6 ]. Breast milk microbiome could be individually varied according to genetics, diet, lifestyle, lactation period, and way of delivery [ 35 ].…”
Section: Discussionsupporting
confidence: 71%
See 1 more Smart Citation
“…Although Lactobacillus and Bifidobacterium are usual probiotics of breast milk, they formed only 0.4% and 1.7% of isolated probiotics. This was also shown by Chen et al (2020), who have even recorded their absence in some milk samples [ 6 ]. Breast milk microbiome could be individually varied according to genetics, diet, lifestyle, lactation period, and way of delivery [ 35 ].…”
Section: Discussionsupporting
confidence: 71%
“…Probiotics are microorganisms that can hinder other pathogens, enhancing the quality of the microbiota and preserving a stable eubiosis; thus, they can prevent or even cure diseases [ 6 , 7 ]. Probiotics are suggested to exert their action via competition with the pathogen for nutrition and binding sites, and/or enhancing arginine deiminase system activity.…”
Section: Introductionmentioning
confidence: 99%
“…The main cause behind caries is acids produced by oral bacteria such as S. mutans , which can demineralize the dental enamel (Eick 2021). There are also reports that A. naeslundii is an early colonizer of dental surfaces and a common bacteria of the multispecies cariogenic biofilm (Dige et al 2009; Cieplik et al 2018; Chen et al 2020). At the same time, symbioses of oral flora also play important roles in oral health.…”
Section: Discussionmentioning
confidence: 99%
“…In caries prevention, probiotics can colonize the oral cavity and displace cariogenic bacteria. In general, probiotics can produce various antimicrobial substances—such as bacteriocins and bacteriocin-like peptides, lactic acid, and H 2 O 2 —that increase the medium’s pH and activate immune response cells such as macrophages, neutrophils, and natural killer cells to attack pathogens [ 107 , 108 , 109 , 110 , 111 , 112 ].…”
Section: Strategies To Combat Caries By Maintaining the Integrity Of ...mentioning
confidence: 99%