Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?

Ghavami, Shaghayegh Baradaran; Aghdaei, Hamid Asadzadeh; Sorrentino, Dario; Shahrokh, Shabnam; Farmani, Maryam; Ashrafian, Fatemeh; Dore, Maria Pina; Raftar, Shahrbanoo Keshavarz Azizi; Khoramjoo, Seyed Mobin; Zali, Mohammad Reza

doi:10.3390/ijms22158274

Cited by 21 publications

(10 citation statements)

References 113 publications

(132 reference statements)

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“…Other probiotic strains, such as Lactiplantibacillus (formerly Lactobacillus ) plantarum and Bifidobacterium longum , have been documented to alleviate chemically induced colitis by restoring the Th17/Treg balance in the lamina propria of the colon [ 72 ]. Probiotic bacteria might attenuate inflammation also by regulating the maturation of dendritic cells (DC) and producing tolerogenic DCs [ 73 , 74 , 75 ]. The immunomodulatory effect of probiotics is often coupled with their ability to improve the integrity and permeability of the disrupted intestinal barrier [ 76 ].…”

Section: Conventional Probiotics and Ucmentioning

confidence: 99%

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

et al. 2022

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Although there are number of available therapies for ulcerative colitis (UC), many patients are unresponsive to these treatments or experience secondary failure during treatment. Thus, the development of new therapies or alternative strategies with minimal side effects is inevitable. Strategies targeting dysbiosis of gut microbiota have been tested in the management of UC due to the unquestionable role of gut microbiota in the etiology of UC. Advanced molecular analyses of gut microbiomes revealed evident dysbiosis in UC patients, characterized by a reduced biodiversity of commensal microbiota. Administration of conventional probiotic strains is a commonly applied approach in the management of the disease to modify the gut microbiome, improve intestinal barrier integrity and function, and maintain a balanced immune response. However, conventional probiotics do not always provide the expected health benefits to a patient. Their benefits vary significantly, depending on the type and stage of the disease and the strain and dose of the probiotics administered. Their mechanism of action is also strain-dependent. Recently, new candidates for potential next-generation probiotics have been discovered. This could bring to light new approaches in the restoration of microbiome homeostasis and in UC treatment in a targeted manner. The aim of this paper is to provide an updated review on the current options of probiotic-based therapies, highlight the effective conventional probiotic strains, and outline the future possibilities of next-generation probiotic and postbiotic supplementation and fecal microbiota transplantation in the management of UC.

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Section: Conventional Probiotics and Ucmentioning

confidence: 99%

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

et al. 2022

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“…Increasing evidence showed that lipid metabolism mediated by GM is involved in the development, maturation, and function of DCs, including bile acids, short-chain fatty acids, specialized pro-resolving mediators, lysophospholipids, endogenous cannabinoids, oxysterols, and sphingolipids [ 12 , 49 , 50 ]. In the present study, colitis mice with SKYD syndromes showed significant dysregulation of metabolites, while 13 metabolites were effectively reversed after SSP treatment.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, 25 mg/ kg hydrocortisone injection was injected into the buttocks of mice (days 8-14). Mice were then given 3% (wt/vol) dexglycan sodium sulfate (DSS) dissolved in deionized water (days [8][9][10][11][12][13][14]. Fresh DSS solutions and rhubarb solutions were prepared every morning.…”

Section: Rhubarb + Hydrocortisone + Dss-induced Experimentalmentioning

confidence: 99%

“…The pattern recognition receptor responses of DCs are critical for regulating interactions between innate and adaptive immunity, cytokines, and microbiota in IBD [ 11 ]. Some studies have also reported that various probiotics and their metabolites can suppress the inflammatory response by regulating DCs maturation and producing tolerant DCs, which is also considered a new approach for treating IBD [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF-κB Pathway

Zhou

Zhong

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Sishen pill (SSP) is an old Chinese medicine used to treat colitis with spleen-kidney-yang deficiency (SKYD) syndromes. However, its exact mechanism of action has not yet been fully elucidated. The aim of this study was to evaluate the effects and potential mechanisms of SSP on colitis with SKYD syndromes in mice. Colitis with SKYD syndromes was induced by rhubarb, hydrocortisone, and dextran sulfate sodium (DSS), and treatment was provided with SSP. Flow cytometry was performed to examine the inflammatory dendritic cell (infDC) regulations of SSP. The changes in the gut microbiota (GM) and fecal metabolites post-SSP treatment were investigated using the combination of 16S rRNA sequencing and untargeted metabolomics. Additionally, we also examined whether SSPs could regulate the infDCs by modifying TLR4/NF-κB signaling pathways. Compared with the DSS group, the disease activity index, colonic weight, index of colonic weight, and colonic injury scores, as well as the levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, and IL-12p70 decreased significantly in the DSS + SSP group, while free triiodothyronine (FT3), free tetraiodothyronine (FT4), testosterone (TESTO), body weight change, colonic length, and the levels of IL-10 increased. Also, SSP decreased the amounts of CD103+CD11c+iNOS+, CD103+CD11c+TNF-α+, CD11c+CD103+CD324+, CD103+CD11c+MHC-II+, and CD103+CD11c+CD115+. Interestingly, 16S rRNA sequencing and untargeted metabolomics showed that SSP treatment restored the dysbiosis of GM and improved the dysfunction in fecal metabolism in colitis mice with SKYD syndromes. Correlation analysis indicated that the modulatory effects of SSP on FT3, FT4, IL-10, colonic weight index, CD103+CD11c+TNF-α+, CD103+CD11c+MHC-II+, and 13 common differential metabolites were related to alterations in the abundance of Parvibacter, Aerococcus, norank_f_Lachnospiraceae, Lachnospiraceae_UCG-006, Akkermansia, and Rhodococcus in the GM. In addition, SSP markedly inhibited the activation of the TLR4, MyD88, TRAF6, TAB2, and NF-κBp65 proteins and activated IκB. These results indicate that SSP can effectively alleviate colitis mice with SKYD syndrome by regulating infDCs, GM, fecal metabolites, and TLR4/NF-κB signaling pathways.

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“…Recent evidence suggests that probiotics may affect immune regulation in vitro and in vivo by modulating DC maturation and TDC production, thereby suppressing inflammation. 89 The immunomodulatory effects of probiotics arise from the interaction of immune cells with intestinal DCs, thereby regulating the innate and adaptive immune systems. 90 Studies have shown that probiotics are able to react with pattern recognition receptors (PRRs) on DCs, which detect distinct evolutionarily conserved structures (pathogen-associated molecular patterns, PAMPs) on pathogens, or by producing soluble compounds, thereby inducing TDCs.…”

Section: Mechanisms Of Probiotic Treatment Of Allergic Rhinitismentioning

confidence: 99%

Research Advances in the Treatment of Allergic Rhinitis by Probiotics

Liu¹,

Hu²,

Kang³

et al. 2022

JAA

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Allergic rhinitis (AR) impairs the quality of life of patients and reduces the efficiency of social work, it is an increasingly serious public medical and economic problem in the world. Conventional anti-allergic drugs for the treatment of allergic rhinitis (AR) can cause certain side effects, which limit the quality of life of patients. Therefore, it makes sense to look for other forms of treatment. Several studies in recent years have shown that probiotics have shown anti-allergic effects in various mouse and human studies. For example, the application of certain probiotic strains can effectively relieve the typical nasal and ocular symptoms of allergic rhinitis in children and adults, thereby improving the quality of life and work efficiency. At the same time, previous studies in humans and mice have found that probiotics can produce multiple effects, such as reduction of Th2 cell inflammatory factors and/or increase of Th1 cell inflammatory factors, changes in allergy-related immunoglobulins and cell migration, regulate Th1/Th2 balance or restore intestinal microbiota disturbance. For patients with limited activity or allergic rhinitis with more attacks and longer attack duration, oral probiotics have positive effects. The efficacy of probiotics in the prevention and treatment of allergic rhinitis is remarkable, but its specific mechanism needs further study. This review summarizes the research progress of probiotics in the treatment of allergic rhinitis in recent years.

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Probiotic-Induced Tolerogenic Dendritic Cells: A Novel Therapy for Inflammatory Bowel Disease?

Cited by 21 publications

References 113 publications

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

Probiotic-Based Intervention in the Treatment of Ulcerative Colitis: Conventional and New Approaches

Sishen Pill Ameliorates Dextran Sulfate Sodium (DSS)-Induced Colitis with Spleen-Kidney Yang Deficiency Syndromes: Role of Gut Microbiota, Fecal Metabolites, Inflammatory Dendritic Cells, and TLR4/NF-κB Pathway

Research Advances in the Treatment of Allergic Rhinitis by Probiotics

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