Probiotic kefir consumption improves serum apolipoprotein A1 levels in metabolic syndrome patients: a randomized controlled clinical trial

Koyu, Ezgi Bellikci; Sarer-Yurekli, B.P.; Karagözlü, Cem; Köse, Fadime Aydın; Özgen, A. Gökhan; Büyüktuncer, Zehra

doi:10.1016/j.nutres.2022.02.006

Cited by 16 publications

(7 citation statements)

References 49 publications

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“…Bellikci-Koyu et al showed that patients with metabolic syndrome experienced a decrease in serum concentrations of proinflammatory cytokines (TNF-α, IL-6, and interferon-gamma), but also experienced a decrease in IL-10 with kefir administration. The same study showed increases in serum apolipoprotein A1 concentrations versus placebo but showed no differences in serum apolipoprotein B and LDL concentrations [66]. In another study by the same group, both kefir and the placebo lowered serum concentrations of both insulin and the same cytokines; thus, these decreases cannot be attributed to kefir administration [67].…”

Section: Clinical Trialsmentioning

confidence: 89%

The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review

Culpepper¹

2022

Cureus

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Kefir, a fermented beverage made from kefir grains, has gained immense popularity around the world due to its potential health-promoting properties. Kefir beverages are both marketed commercially and brewed privately by individuals. Both milk and sugar solutions can be used as substrates with various additives included based on consumer preference. Fermentation occurs via microorganisms including lactic acid bacteria, acetic acid bacteria, and yeasts, which are naturally present in kefir grains. Health-promoting effects of kefir are thought to occur through immune, gastrointestinal, and metabolic regulation. Both clinical trials and mechanistic studies in cell culture and animal models have explored these effects. Studies in vitro and in animals have shown the ability of kefir and kefir components to antagonize pathogens, reduce proinflammatory cytokine production, contribute to cytotoxicity of tumor cell lines and reduce tumor burden, and improve serum glycemic and lipid profiles. However, some data from clinical trials are conflicting, and the precise mechanisms by which kefir promotes well-being are not completely defined. This review summarizes the current body of evidence in both cell culture and animal models that provide insight into the mechanisms by which kefir beverages may protect consumers from enteric infections and improve immune and metabolic health. We believe that readers will gain knowledge helpful for both developing more targeted mechanistic studies and selecting informative outcomes when designing clinical studies.

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Section: Clinical Trialsmentioning

confidence: 89%

The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review

Culpepper¹

2022

Cureus

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“…Kefir has now been proven to have a wide range of health benefits, such as antimicrobial activity (Bekar et al., 2011), against viral infection (Hamida et al., 2021), antihypertensive (Friques et al., 2015), immune regulation, antioxidant effect, anti‐diabetes effect (Bellikci‐Koyu et al., 2022; Nurliyani et al., 2015), anti‐allergic effect, and anti‐tumor (Azizi et al., 2021; Slattery et al., 2019). The anti‐carcinogenic role of kefir and the fractions of kefir can be related to the prevention of cancer and retardation of tumor growth by apoptosis (Maalouf et al., 2011), immune response (Culpepper, 2022), modulation of gut microbiota (Peluzio et al., 2021; Yılmaz et al., 2019), decreased tumor growth and DNA damage (Zeng et al., 2021), anti‐oxidative process (Ali et al., 2020; Kumar et al., 2021), and inhibition of proliferation, and activation of pro‐carcinogens (Rafie et al., 2015; Sharifi et al., 2017).…”

Section: Fermented Milk and Lactic Acid Bacteria—first Look At Nutrit...mentioning

confidence: 99%

From the past to the future: Fermented milks and their health effects against human diseases

Zhang,

Geng,

Cheng

et al. 2023

Food Frontiers

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The benefits of fermented milk have been known to mankind since the ancient days of civilization. The important role of fermented milk in human nutrition has been well documented through the ages, from the original unpredictable souring of milk caused by the microorganisms inherent in milk to modern microbiological processes, leading to fermented milk with the greater nutritional value produced under controlled conditions. The bioactive peptides synthesized by the microbial degradation of proteins in fermented milk and the addition of supplements, such as probiotics and prebiotics endow them with various physiological functions, including the regulation of the gut microbiota, cholesterol lowering, and immunomodulation, making them potential functional foods that are notable in healthy diets. Here, we summarized the development of fermented milk into four stages and also summarized their impact on health and diseases during different developmental stages. In addition, we described the characteristics and limitations of fermented milk in different eras. Accordingly, we integrated the future trends in the development of fermented milk as functional foods. It is hoped that the efforts to develop the potential of fermented milk as functional foods will help manage the health risks faced by many countries.

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“…diacetylactis, Leuconostoc mesenteroides subsp. cremoris, Lactobacillus kefyr, Kluyveromyces marxianus , and Saccharomyces unisporus , was tested on patients with MS [ 72 ]. A significant increase in serum apolipoprotein A1 concentrations was provided by kefir compared to milk consumption.…”

Section: Administration Of Probiotic Supplementsmentioning

confidence: 99%

Microbiota Modulation in Patients with Metabolic Syndrome

2022

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Metabolic syndrome (MS) comprises a vast range of metabolic dysfunctions, which can be associated to cardiovascular disease risk factors. MS is reaching pandemic levels worldwide and it currently affects around 25% in the adult population of developed countries. The definition states for the diagnosis of MS may be clear, but it is also relevant to interpret the patient data and realize whether similar criteria were used by different clinicians. The different criteria explain, at least in part, the controversies on the theme. Several studies are presently focusing on the microbiota changes according to the components of MS. It is widely accepted that the gut microbiota is a regulator of metabolic homeostasis, being the gut microbiome in MS described as dysbiotic and certain taxonomic groups associated to metabolic changes. Probiotics, and more recently synbiotics, arise as promising therapeutic alternatives that can mitigate some metabolic disturbances, namely by correcting the microbiome and bringing homeostasis to the gut. The most recent studies were revised and the promising results and perspectives revealed in this review.

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Probiotic kefir consumption improves serum apolipoprotein A1 levels in metabolic syndrome patients: a randomized controlled clinical trial

Cited by 16 publications

References 49 publications

The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review

The Effects of Kefir and Kefir Components on Immune and Metabolic Physiology in Pre-Clinical Studies: A Narrative Review

From the past to the future: Fermented milks and their health effects against human diseases

Microbiota Modulation in Patients with Metabolic Syndrome

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