Probiotic lactobacilli and bifidobacteria in a fermented milk product with added fruit preparation reduce antibiotic associated diarrhea andHelicobacter pyloriactivity

Abstract

To investigate matrix-specifity of probiotic effects and particularly of the reduction of antibiotics-associated diarrhea, a controlled, randomized, double-blind study was performed, in which 88 Helicobacter pylori-infected but otherwise healthy subjects were given for eight weeks either a) a probiotic fruit yoghurt "mild" containing Lactobacillus acidophilus LA-5 plus Bifidobacterium lactis BB-12, n = 30), b) the same product but pasteurized after fermentation (n = 29) or c) milk acidified with lactic acid (control, n = 29). During week five, a Helicobacter eradication therapy was performed. Helicobacter activity was measured via 13C-2-urea breath tests and antibiotic-associated diarrhoea and other gastrointestinal complaints were recorded by validated questionnaires. In intervention group a, b and c the mean number of days with diarrhoea was 4, 10 and 10 (P<0·05), the frequency of episodes 17%, 7% and 27% (n.s.), and the change in total symptoms score before antibiotics treatment was -1·4 ± 1·1, -1·2 ± 1·1, 2·6 ± 1·1 points/four weeks (P<0·05). All milk products decreased Helicobacter activity by 18 to 45% without significant differences between groups. The observed decrease in Hel. pylori activity seems to be not or not only due to probiotic bacteria but (rather) to components of acidified milk (most probably lactic acid). Fruit-yogurt-like fermented milk products with living probiotic bacteria significantly shorten the duration of antibiotics-associated diarrhoea and improve gastrointestinal complaints. Fruit yogurt-like fermented milk is a matrix suitable for probiotic bacteria.

Systematic review and meta-analysis: Multi-strain probiotics as adjunct therapy forHelicobacter pylorieradication and prevention of adverse events

“…24 In one study, no placebo was used, but the outcome assessor was blinded as to the treatment given. 39 The placebos used in five control arms were of identical appearance and given in the same delivery vehicle as the probiotic: sachets, 25 or fruit drink, 40 or yogurt, 41 or fermented drink (two arms). 24 Most, 15 (75%) of the treatment arms were open trials (no placebos).…”

“…A total of 19 randomized controlled trials (2730 participants) using six different types of multi-strain probiotic mixtures are included in this analysis (Table 1), [24][25][26][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53] of which one trial had multiple treatment arms, resulting in a total of 20 treatment arms. 24 The study size of the trials ranged from 20-192, with a mean number per trial of 63.3 AE 41.3 in the probiotic arms and 73.2 AE 55.0 in control arms.…”

Linex forte in the prevention and treatment of gastrointestinal diseases

“…Добавление этих пробиотиков к стандартным режимам эра-дикационной терапии хеликобактериоза позволяло снизить не только частоту диареи, вызываемой антибиотиками [68,69], но и существенно активность H. pylori и повысить частоту его эрадика-ции [73,74].…”

Lactobacillus plantarum PADA FESES INDIVIDU DEWASA SEHAT YANG MENGONSUMSI Lactobacillus plantarum IS-10506 DARI DADIH

“…Bakteri probiotik yang umumnya ditambahkan dalam produk fermentasi susu adalah Lactobacillus dan Bifidobacteria (de Vrese M et al 2011).…”