Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats

Zhang, Yong; Wang, Lifeng; Zhang, Jiachao; Li, Yunxu; He, Qiuwen; Lin, He; Guo, Xiao; Guo, Jianlin; Zhang, Heping

doi:10.1007/s00394-013-0519-5

Cited by 72 publications

(52 citation statements)

References 41 publications

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“…Interestingly, in our model the administration of L. kefiri completely prevented the alterations caused by FRD intake, which strongly support the beneficial effect of this probiotic. In concordance with our results, other studies have shown that the use of Lactobacillus species as probiotics improves the metabolic disorders induced by the FRD [49,50]. …”

Section: Discussionsupporting

confidence: 93%

“…On the other hand, Zhang et al reported that FRD supplemented with L. casei , increased intestinal Bacteroides fragilis ( Bacteroidetes phylum) and decreased Clostridium spp. ( Firmicutes phylum) quantities, at the same time that it improved the oral glucose tolerance test in FRD-fed rats [50]. In line with these results, FRD-fed mice supplemented with L. kefiri showed an increase in B. fragilis , but no changes in Clostridium coccoides group, accompanied by an improvement of several metabolic alterations caused by FRD intake.…”

Section: Discussionmentioning

confidence: 56%

“…Some studies showed that fructose intake produces a decrease in Bacteroidetes , while others stated no changes or even an increment [49,67]. Similarly, for Firmicutes , an increase or no changes were reported [49,50,67]. In our study, we analyzed if both variables studied (FRD and Lk administration) affected the microbiota composition of treated mice.…”

Section: Discussionmentioning

confidence: 88%

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Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

et al. 2017

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Modern lifestyle and diets have been associated with metabolic disorders and an imbalance in the normal gut microbiota. Probiotics are widely known for their health beneficial properties targeting the gut microbial ecosystem. The aim of our study was to evaluate the preventive effect of Lactobacillus kefiri (L. kefiri) administration in a fructose-rich diet (FRD) mice model. Mice were provided with tap water or fructose-added (20% w/v) drinking water supplemented or not with L. kefiri. Results showed that probiotic administration prevented weight gain and epidydimal adipose tissue (EAT) expansion, with partial reversion of the adipocyte hypertrophy developed by FRD. Moreover, the probiotic prevented the increase of plasma triglycerides and leptin, together with the liver triglyceride content. Leptin adipocyte secretion was also improved by L. kefiri, being able to respond to an insulin stimulus. Glucose intolerance was partially prevented by L. kefiri treatment (GTT) and local inflammation (TNFα; IL1β; IL6 and INFγ) was completely inhibited in EAT. L. kefiri supplementation generated an impact on gut microbiota composition, changing Bacteroidetes and Firmicutes profiles. Overall, our results indicate that the administration of probiotics prevents the deleterious effects of FRD intake and should therefore be promoted to improve metabolic disorders.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 88%

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Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

et al. 2017

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“…Liver glycogen contents were significantly decreased ( p < 0.05). In therapeutic group, L. casei Zhang administration possessed improved glucose tolerance ( p < 0.05), which were associated with increased osteocalcin level ( p < 0.01), improved intestinal bile acids secretion ( p = 0.060), decreased serum MDA levels ( p < 0.05) and upregulation of LXR-α, PPAR-γ and AdipoR2 gene expression.[64] Lactobacillus reuteri GMNL-263High levels of serum glucose, insulin, leptin, C-peptide, glycated hemoglobin, GLP-1, liver injury markers, lipid profile in serum and liver in high-fructose-fed rats were significantly suppressed after Lr263 administration. Feeding of Lr263 reversed the decreased number of bifidobacterium species and lactobacillus species and increased number of clostridium species induced by high fructose treatment.…”

Section: Probiotic Lab and Type-2 Diabetes Treatmentmentioning

confidence: 99%

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Evivie

Gui-cheng

Igene

et al. 2017

Food & Nutrition Research

150

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Several mechanism and non-mechanism-based studies supporting the claim that lactic acid bacteria (LAB) strains confer health benefits and play immune-modulatory roles were examined in this review. Probiotic applications of LAB on global burdens such as obesity and type-2 diabetes were discussed as well as the use of yoghurt and ice cream as important vehicles to convey several beneficial LAB strains. Probiotic and symbiotic dairy products may be used in the nearest future to treat a variety of health disorders. Current studies suggest that lactic acid bacteria possess anti-obesity and anti-diabetic propensities on their hosts and thus can play a crucial role in human health care. Research in the rheological and physicochemical properties of ice cream as well as its applications are also on the increase. These applications face certain hurdles including technological (for less developed countries), consumer acceptability of new functional foods may be influenced by culture, ethics or religion. There is need for more studies on the genetic basis for probiotic properties which will give further understanding regarding novel manipulation skills and applicability in nutrition and health sectors. More studies confirming the direct effects of probiotic LABs in lowering the spread of food-borne and other pathogens are also anticipated.

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“…In our previous work, we demonstrated that Lactobacillus casei Zhang could enrich Bacteroides fragilis and stimulate adiponectin receptor 2 signaling [17]. It has reported that vitamin K2 also enrich Bacteroides and vitamin K2-dependent osteocalcin can increase adiponectin expression[18–19].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus casei Zhang and vitamin K2 prevent intestinal tumorigenesis in mice via adiponectin-elevated different signaling pathways

Zhang

Zhao

et al. 2017

Oncotarget

Self Cite

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The incidence of colon cancer has increased considerably and the intestinal microbiota participate in the development of colon cancer. We showed that the L. casei Zhang or vitamin K2 (Menaquinone-7) intervention significantly alleviated intestinal tumor burden in mice. This was associated with increased serum adiponectin levels in both treatments. But osteocalcin level was only increased by L. casei Zhang. Furthermore, the anti-carcinogenic actions of L. casei Zhang were mediated by hepatic Chloride channel-3(CLCN3)/Nuclear Factor Kappa B(NF-κB) and intestinal Claudin15/Chloride intracellular channel 4(CLIC4)/Transforming Growth Factor Beta(TGF-β) signaling, while the vitamin K2 effect involved a hepatic Vitamin D Receptor(VDR)-phosphorylated AMPK signaling pathway. Fecal DNA sequencing by the Pacbio RSII method revealed there was significantly lower Helicobacter apodemus, Helicobacter mesocricetorum, Allobaculum stercoricanis and Adlercreutzia equolifaciens following both interventions compared to the model group. Moreover, different caecum acetic acid and butyric acid levels and enrichment of other specific microbes also determined the activity of the different regulatory pathways. Together these data show that L. casei Zhang and Vitamin K2 can suppress gut risk microbes and promote beneficial microbial metabolites to reduce colonic tumor development in mice.

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Probiotic Lactobacillus casei Zhang ameliorates high-fructose-induced impaired glucose tolerance in hyperinsulinemia rats

Cited by 72 publications

References 41 publications

Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

Deleterious Metabolic Effects of High Fructose Intake: The Preventive Effect of Lactobacillus kefiri Administration

Some current applications, limitations and future perspectives of lactic acid bacteria as probiotics

Lactobacillus casei Zhang and vitamin K2 prevent intestinal tumorigenesis in mice via adiponectin-elevated different signaling pathways

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