Probiotic-Mediated Protection Against Chronic Water-Avoidance Stress Enteritis in Mice is Associated with Lamina Propria Plasmacytoid Dendritic Cell Infiltration

Chen, Chun-Chia; Chow, Bryan T.; Sun, Yundong; Zhang, Min; El–Zaatari, Mohamad; Grasberger, Helmut; Kao, John Y.

doi:10.1016/s0016-5085(17)32210-2

Cited by 2 publications

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“…In a clinical study by Fang et al [24] that investigated patients with sepsis in an intensive care unit, IL-10 and granulocyte colony-stimulating factor (G-CSF) levels and mortality in patients with active cancer were increased when compared with patients without active cancer. IL-10 is an anti-inflammatory cytokine that plays a crucial role in controlling inflammation and preventing enteritis [25], while G-CSF is also linked with the generation of IFN-γ [26]. Therefore, IL-10 and G-CSF should also be considered as potential treatments for sepsis.…”

Section: Discussionmentioning

confidence: 99%

Treatment with Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis

et al. 2019

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Background This study aimed to investigate the effects of treatment with recombinant interleukin-15 (IL-15) on T cells, natural killer (NK) cells, and interferon-γ (IFN-γ) on the immune response in a rat cecal ligation and perforation model of sepsis. Material/Methods Sprague-Dawley rats (n=120) were divided into four groups (n=30). A rat model of clinical sepsis was created using cecal ligation and perforation, and 109 rats successfully developed sepsis. Rats were then injected intraperitoneally with 0.5, 1.0, and 1.5 μg of recombinant rat IL-15 or saline. Survival was determined, and the numbers of T cells and NK cells, and the expression levels of IL-15 and IFN-γ were detected in the peripheral blood of rats in each group at 24 h and 48 h. Results The levels of IL-15 and IFN-γ, as well as the numbers of T cells and NK cells, were significantly increased in the IL-15-treated groups compared with the control group at both 24 h and 48 h (P<0.05). Levels of IL-15 and IFN-γ were significantly increased in the IL-15-treated groups at 48 h compared with 24 h in the control group. Levels of IL-15, the numbers of T cells and NK cells, and the levels of IFN-γ in peripheral blood were significantly lower at 48 h when compared with 24 h (P<0.05). Conclusions In a rat model of sepsis, treatment with recombinant IL-15 significantly increased T cell and NK cell numbers, and levels of IFN-γ, and prolonged the survival of rats with sepsis.

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Section: Discussionmentioning

confidence: 99%