Probiotic properties of lactic acid bacteria isolated from Mukeunji, a long-term ripened kimchi

Kim, Sung-Eon; Kim, Younghun; Lee, Hyungjae; Kim, Dae‐Ok; Kim, Hae‐Yeong

doi:10.1007/s10068-012-0148-4

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…; Lee and Lee ). Probiotic effects of kimchi LAB such as anticarcinogenic, immunomodulatory, antimicrobial, antidiarrhoeal and anti‐allergy activities have been reported by several authors (Park ; Kim ; Kim et al . ).…”

Section: Introductionmentioning

confidence: 88%

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Moon

Soh

et al. 2012

J Appl Microbiol

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Aims: To investigate the intracellular lipid accumulation inhibitory effect of spent culture medium extract and the cytoplasmic fraction of Weissella koreensis OK1-6 cells isolated from kimchi in differentiating 3T3-L1 cells. Methods and Results: Differentiating 3T3-L1 cells were treated with either cytoplasmic fraction of W. koreensis OK1-6 cells or its spent media for 4 days. Both the spent culture medium extract and cytoplasmic fraction of W. koreensis OK1-6 cells significantly decreased the triglyceride concentration and intracellular lipid accumulation in the treated groups compared with the control group. The mRNA expression levels of C/EBP-a, one of the major transcriptional factors involved in adipocyte differentiation, were significantly less expressed in 3T3-L1 cells treated with the spent medium and cytoplasmic fraction. The expressions of aP2, fatty acid synthase (FAS) and SREBP1 genes were also decreased significantly. Conclusions: These results suggested that W. koreensis OK1-6 could play a crucial role in preventing intracellular lipid accumulation by down-regulating the expression of adipocyte-specific genes C/EBPa, aP2, SREBP1 and FAS. Significance and Impact of the Study: These results may contribute to nutraceutical and food industries in developing probiotic-based therapies for the treatment and prevention of obesity.

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Section: Introductionmentioning

confidence: 88%

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Moon

Soh

et al. 2012

J Appl Microbiol

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“…13,14 LAB have been evaluated for their nutritional, physiological and pharmacological aspects, which have raised awareness of the functional effect of Korean traditional foods, including kimchi. 15 Recently, Lactobacillus has been examined for their ability to prevent obesity. In our earlier study, we reported that Lactobacillus plantarum LG42 isolated from gajami sik-hae inhibits adipogenesis in 3T3-L1 adipocytes, as well as decreasing intracellular triglyceride content.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus brevisOPK‐3 isolated from kimchi inhibits adipogenesis and exerts anti‐inflammation in 3T3‐L1 adipocyte

Park

Cha

2014

J Sci Food Agric

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“…LAB is a viable bacteria that beneficially influence the health of the host. Recently, LAB has been revaluated for their nutritional, physiological, and pharmacological aspects, which have raised attention towards the functional effect of Korean traditional foods including kimchi and joet-gal [5]. Various nutritional and therapeutic effects ascribed to LAB in the human body are the metabolic stimulation of vitamin synthesis and enzyme production, antimutation, anticancer, gastric secretomotor, and immune function [6].…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus plantarumLG42 Isolated from Gajami Sik-Hae Inhibits Adipogenesis in 3T3-L1 Adipocyte

Park

Cha

2013

BioMed Research International

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We investigated whether lactic acid bacteria isolated from gajami sik-hae (GLAB) are capable of reducing the intracellular lipid accumulation by downregulating the expression of adipogenesis-related genes in differentiated 3T3-L1 cells. The GLAB, Lactobacillus plantarum LG42, significantly decreased the intracellular triglyceride storage and the glycerol-3-phosphate dehydrogenase (GPDH) activity in a dose-dependent manner. mRNA expression of transcription factors like peroxisome proliferator-activated receptor (PPAR) γ and CCAAT/enhancer-binding protein (C/EBP) α involved in adipogenesis was markedly decreased by the GLAB treatment. Moreover, the GLAB also decreased the expression level of adipogenic markers like adipocyte fatty acid binding protein (aP2), leptin, GPDH, and fatty acid translocase (CD36) significantly. These results suggest that the GLAB inhibits lipid accumulation in the differentiated adipocyte through downregulating the expression of adipogenic transcription factors and other specific genes involved in lipid metabolism.

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Probiotic properties of lactic acid bacteria isolated from Mukeunji, a long-term ripened kimchi

Cited by 16 publications

References 20 publications

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Intracellular lipid accumulation inhibitory effect of Weissella koreensis OK1-6 isolated from Kimchi on differentiating adipocyte

Lactobacillus brevisOPK‐3 isolated from kimchi inhibits adipogenesis and exerts anti‐inflammation in 3T3‐L1 adipocyte

Lactobacillus plantarumLG42 Isolated from Gajami Sik-Hae Inhibits Adipogenesis in 3T3-L1 Adipocyte

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