Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment

Yue, Yuanchun; Yang, Kai; Lu, Joan; Wang, Xinyu; Zhang, Shuwen; Liu, Liu; Yang, Baoyu; Nassar, Khaled S.; Xu, Xiaoxin; Pang, Xiaoyang; Lv, Jing

doi:10.1016/j.biopha.2020.110159

Cited by 80 publications

(51 citation statements)

References 28 publications

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“…Lactobacillus rhamnosus GG and L. casei M3 were obtained from the Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing, China. L. plantarum YYC-3 was isolated from fermented rose juice, as previously described [ 23 ]. All the strains obtained were cultured using 5% inoculum size in 100 mL MRS broth, and then incubated anaerobically in an anaerobic jar (UNITECH, UT706, China) together with GENbag anaer (AnaeroGen, Oxoid) at 37 °C without shaking for 24 h. Thereafter, 1 mL of these cultures, containing about 10 9 colony-forming units/mL of LAB, was centrifuged at 6010× g for 10 min and the supernatants were retained.…”

Section: Methodsmentioning

confidence: 99%

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Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway

Yue

Yang

et al. 2020

Microb Cell Fact

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Background Colorectal cancer (CRC) is a major clinical challenge, and the gut microbiome plays important roles in the occurrence and metastasis of CRC. Lactobacillus and their metabolites are thought to be able to suppress the growth of CRC cells. However, the antimetastatic mechanism of Lactobacillus or their metabolites toward CRC cells is not clear. Therefore, the aim of this study was to assess the inhibitory mechanism of cell-free supernatants (CFSs) of L. rhamnosus GG, L. casei M3, and L. plantarum YYC-3 on metastasis of CRC cells. Results YYC-3 CFS showed the highest inhibitory effect on CRC cell growth, invasion and migration, and inhibited MMP2, MMP9, and VEGFA gene and protein expression, and protein secretion. Furthermore, it suppressed the activities of MMPs by gelatin zymography. Moreover, the effective compounds in these CFSs were analyzed by Q Exactive Focus liquid chromatography–mass spectrometry. Conclusions Our results showed that metabolite secretions of YYC-3 may inhibited cell metastasis by downregulating the VEGF/MMPs signaling pathway. These data suggest that treatment of CRC cells with metabolites from L. plantarum YYC-3 may reduce colon cancer metastasis.

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Section: Methodsmentioning

confidence: 99%

“…We found that L . plantarum YYC-3 modulated the tumour microenvironment to prevent colon cancer in APC Min/ + model mice [ 23 ]. However, the direct effects of L .…”

Section: Introductionmentioning

confidence: 99%

Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway

Yue

Yang

et al. 2020

Microb Cell Fact

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“…Since Lactobacillus has been reported as an effective treatment to prevent both infectious and antibiotic-associated diarrhea ( Vanderhoof et al., 1999 ), many people take food supplements containing Lactobacillus to treat general digestion problems. Lactobacillus was reported to be beneficial for irritable bowel syndrome (IBS), chronic idiopathic constipation (CIC) ( Ford et al., 2014 ), breastfed infants with colic ( Johnson et al., 2015 ; Sung et al., 2018 ), inflammatory bowel disease (IBD) ( Le and Yang, 2018 ), the growth inhibition of H. pylori in the gut ( Liyuan et al., 2018 ), stomach pain, constipation, colon inflammation, and control of cancer progression through postponing the metastasis process ( Heydaria et al., 2019 ; Yuea et al., 2020 ). However, products from Lactobacillus have a short shelf life, requiring special storage condition and high technology in the production process.…”

Section: Introductionmentioning

confidence: 99%

Potential of Musa sapientum Linn. for digestive function promotion by supporting Lactobacillus sp.

Jaiturong

Laosirisathian

Sirithunyalug

et al. 2020

Heliyon

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Lactobacillus is a beneficial bacteria that could inhibit pathogenic potential of other microorganisms. This is the first study to develop a potential tablet from Musa sapientum Linn. (locally known as Kluai Namwa) using the direct compression method to support Lactobacillus sp. We compared the amount of resistant starch and prebiotic properties of the dry powder from unpeeled raw fruit, peeled raw fruit, and starch from M. sapientum . These dry powders were formulated into tablets using the direct compression method and evaluated for their prebiotic index compared to their native powder. Resistant starch, which possessed the highest prebiotic index, generated a tablet that possessed remarkable in vitro prebiotic properties. All tablets met the requirement of the United States Pharmacopeia. Therefore, resistant starch tablets from M. sapientum are suggested for use as a health promotion product.

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“…Treatment with a specific strain of L. rhamnosus decreased tumor incidence by inhibiting inflammation and promoting apoptosis (Gamallat et al, 2016). In APCMin/+ mouse model of colon cancer, L. plantarum strain YYC-3 prevented colon tumor development, putatively by suppressing the production of inflammatory cytokines and infiltration of inflammatory cells (Yue et al, 2020). Administration of a mixture of Lactobacillus acidophilus, L. rhamnosus and Bifidobacterium bifidum decreased colitis and resulted in a 40% lower number of tumors than the control group (Mendes et al, 2018).…”

Section: Possible Preventive and Therapeutic Strategy For Colorectal mentioning

confidence: 99%

Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

Loke

Chew

Ngeow

et al. 2020

Front. Cell. Infect. Microbiol.

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Colorectal cancer (CRC) incidence increases yearly, and is three to four times higher in developed countries compared to developing countries. The well-known risk factors have been attributed to low physical activity, overweight, obesity, dietary consumption including excessive consumption of red processed meats, alcohol, and low dietary fiber content. There is growing evidence of the interplay between diet and gut microbiota in CRC carcinogenesis. Although there appears to be a direct causal role for gut microbes in the development of CRC in some animal models, the link between diet, gut microbes, and colonic carcinogenesis has been established largely as an association rather than as a cause-and-effect relationship. This is especially true for human studies. As essential dietary factors influence CRC risk, the role of proteins, carbohydrates, fat, and their end products are considered as part of the interplay between diet and gut microbiota. The underlying molecular mechanisms of colon carcinogenesis mediated by gut microbiota are also discussed. Human biological responses such as inflammation, oxidative stress, deoxyribonucleic acid (DNA) damage can all influence dysbiosis and consequently CRC carcinogenesis. Dysbiosis could add to CRC risk by shifting the effect of dietary components toward promoting a colonic neoplasm together with interacting with gut microbiota. It follows that dietary intervention and gut microbiota modulation may play a vital role in reducing CRC risk.

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Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment

Cited by 80 publications

References 28 publications

Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway

Metabolite secretions of Lactobacillus plantarum YYC-3 may inhibit colon cancer cell metastasis by suppressing the VEGF-MMP2/9 signaling pathway

Potential of Musa sapientum Linn. for digestive function promotion by supporting Lactobacillus sp.

Colon Carcinogenesis: The Interplay Between Diet and Gut Microbiota

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