Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial

Zhang, Juan; Chen, Jie; Ding, Boni; Yongping, Liang; Li, Kai; Yuan, Long; Liao, Qin; Shi, Junren; Huang, Jufang; Wu, Yahong; Ma, Daqing; Ouyang, Wen; Tong, Jianbin

doi:10.1016/j.ejca.2021.11.006

Cited by 62 publications

(38 citation statements)

References 53 publications

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“…These preclinical data are in agreement with a randomized clinical trial concluding that probiotic supplementation during chemotherapy could reduce the incidence of CRCI, by means of an increase in the plasma metabolite p-Mentha-1,8-dien-7-ol and potentially reduced inflammation in breast cancer patients [ 94 ],. Although several Lactobacillus species are currently used as probiotics to improve gastrointestinal health, increased levels of Lactobacilli are not always associated with healthy conditions.…”

Section: Discussionsupporting

confidence: 85%

A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

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Dubois

Desrues

et al. 2022

Cancers

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Chemotherapy-related cognitive impairment (CRCI) and fatigue constitute common complaints among cancer patient survivors. Panax quinquefolius has been shown to be effective against fatigue in treated cancer patients. We developed a behavioral C57Bl/6j mouse model to study the role of a Panax quinquefolius-based solution containing vitamin C (Qiseng®) or vitamin C alone in activity/fatigue, emotional reactivity and cognitive functions impacted by 5-Fluorouracil (5-FU) chemotherapy. 5-FU significantly reduces the locomotor/exploration activity potentially associated with fatigue, evokes spatial cognitive impairments and leads to a decreased neurogenesis within the hippocampus (Hp). Qiseng® fully prevents the impact of chemotherapy on activity/fatigue and on neurogenesis, specifically in the ventral Hp. We observed that the chemotherapy treatment induces intestinal damage and inflammation associated with increased levels of Lactobacilli in mouse gut microbiota and increased expression of plasma pro-inflammatory cytokines, notably IL-6 and MCP-1. We demonstrated that Qiseng® prevents the 5-FU-induced increase in Lactobacilli levels and further compensates the 5-FU-induced cytokine release. Concomitantly, in the brains of 5-FU-treated mice, Qiseng® partially attenuates the IL-6 receptor gp130 expression associated with a decreased proliferation of neural stem cells in the Hp. In conclusion, Qiseng® prevents the symptoms of fatigue, reduced chemotherapy-induced neuroinflammation and altered neurogenesis, while regulating the mouse gut microbiota composition, thus protecting against intestinal and systemic inflammation.

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Section: Discussionsupporting

confidence: 85%

A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

Parment

Dubois

Desrues

et al. 2022

Cancers

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“…Similar results were obtained with doxorubicin, another widely used chemotherapeutic [96]. Because compelling evidence suggests that the microbiota-gut-brain axis is also involved in CICI [97][98][99], it is important to investigate whether dysregulation of TLR signaling in enteric glia anticipates CNS neurodegeneration (see Outstanding questions).…”

Section: Concluding Remarks and Future Perspectivesmentioning

confidence: 52%

Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions

Squillace

Salvemini

2022

Trends in Pharmacological Sciences

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“…Preventing hypoperfusion of the gut and the usage of anti-inflammatory medicine during perioperative period may protect intestinal barrier function in pAD patients. 49 A high level of physical exercise, vegetarian diets, and weight control can improve microbiota conditions before and after surgery alongside other treatments such as probiotics 50,51 and fecal microbiota transplantation 18 which have been reported to benefit gut bacteriome diversity. Given the individualization of microbiota and the numerous influencing factors on colonization, more studies on microbiota therapy are needed.…”

Section: Discussionmentioning

confidence: 99%

Orthopedic Surgery Causes Gut Microbiome Dysbiosis and Intestinal Barrier Dysfunction in Prodromal Alzheimer Disease Patients

Liu

Duan

et al. 2022

Annals of Surgery

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Objective: To investigate gut microbiota and intestinal barrier function changes after orthopedic surgery in elderly patients with either normal cognition (NC) or a prodromal Alzheimer disease phenotype (pAD) comprising either subjective cognitive decline (SCD) or amnestic mild cognitive impairment (aMCI). Background: Homeostatic disturbances induced by surgical trauma and/or stress can potentially alter the gut microbiota and intestinal barrier function in elderly patients before and after orthopedic surgery. Methods: In this prospective cohort study, 135 patients were subject to preoperative neuropsychological assessment and then classified into: NC (n=40), SCD (n=58), or aMCI (n=37). Their gut microbiota, bacterial endotoxin (lipopolysaccharide), tight junction (TJ) protein, and inflammatory cytokines in blood were measured before surgery and on postsurgical day 1, 3, and 7 (or before discharge). Results: The short-chain fatty acid (SCFA)-producing bacteria were lower while the gram-negative bacteria, lipopolysaccharide and TJ were higher preoperatively in both the SCD and aMCI (pAD) groups compared with the NC group. After surgery, a decrease in SCFA-producing bacteria, and an increase in both gram-negative bacteria and plasma claudin were significant in the pAD groups relative to the NC group. SCFA-producing bacteria were negatively correlated with TJ and cytokines in pAD patients on postsurgical day 7. Furthermore, surgery-induced perioperative metabolic stress and inflammatory responses were associated with gut microbiota alterations. Conclusions: Surgery exacerbates both preexisting microbiota dysbiosis and intestinal barrier dysfunction in pAD patients, all of which may be associated with systemic inflammation and, in turn, may lead to further cognitive deterioration.

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Probiotic supplement attenuates chemotherapy-related cognitive impairment in patients with breast cancer: a randomised, double-blind, and placebo-controlled trial

Cited by 62 publications

References 53 publications

A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

A Panax quinquefolius-Based Preparation Prevents the Impact of 5-FU on Activity/Exploration Behaviors and Not on Cognitive Functions Mitigating Gut Microbiota and Inflammation in Mice

Toll-like receptor-mediated neuroinflammation: relevance for cognitive dysfunctions

Orthopedic Surgery Causes Gut Microbiome Dysbiosis and Intestinal Barrier Dysfunction in Prodromal Alzheimer Disease Patients

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