Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome

I, Eizaguirre; Urkia, N. García; Asensio, Anabel; Zubillaga, I.; Zubillaga, P.; Vidales, C. Martín de; García-Arenzana, José María; Aldazábal, P

doi:10.1053/jpsu.2002.32256

Cited by 81 publications

(50 citation statements)

References 16 publications

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“…Harding et al, (2008) reported that probiotics did not stimulate gastrointestinal protein synthesis or reduce the severity of intestinal colitis, but reported an unidentified signaling mechanism between the gut and liver which could be responsible for the probiotic-induced increase in liver protein and plasma protein synthesis. Furthermore, dietary probiotic supplementation may increase the serum protein and albumin concentrations by increasing iron absorption in the lower intestine (Eizaguirre et al, 2002). Alternatively, the lowest decrease in serum protein and albumin, which was dependant on the level of dietary supplementation, was observed in the broilers fed different levels of dietary thyme supplements, in the present experiment.…”

Section: Effect Of Feed Supplements On Broilermentioning

confidence: 46%

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Hosseini

Meimandipour

Alami

et al. 2013

Italian Journal of Animal Science

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A trial was conducted to study the effects of the aromatic plant thyme, a commercial probiotic (Protexin) and avilamycin on broiler performance, blood biochemical parameters and also the antibody response to sheep red blood cells. A total of 750 broilers were assigned into five replicate groups for each of five dietary treatments, namely; control (C), 2.5 mg/kg avilamycin (AB), 0.1 g/kg commercial probiotic (P), 5 g/kg ground thyme (T1), and 7.5 g/kg ground thyme (T2). In general, body weight, feed consumption and feed conversion ratio were not affected by dietary treatments compared to the control birds (P>0.05). Birds fed the P supplemented treatment had the greatest serum protein levels (P<0.001) and highest albumin levels (P<0.001) when compared with control birds, while the birds fed T2 had the lowest (P<0.001). Dietary supplementation reduced (P<0.001) cholesterol and triglyceride concentration in serum of broilers, with the effect were more noticeable by P supplements. Moreover, blood calcium and phosphorus concentrations were higher (P<0.001) in birds fed the P-supplemented diet compared to the birds fed the control diets.This study suggests that probiotic supplementation in particular, and to an intermediate extent ground thyme supplementation in diets of broiler, resulted in chicks with favorably improved blood biochemical parameters and mineral utilization, compared to the birds fed diets supplemented with avilamycin or without any supplementation.

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Section: Effect Of Feed Supplements On Broilermentioning

confidence: 46%

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Hosseini

Meimandipour

Alami

et al. 2013

Italian Journal of Animal Science

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“…It has been shown that probiotics are able to decrease and prevent, to a certain degree, bacterial translocation [14,15]. Probiotics are food supplements containing live bacteria that, theoretically, have beneficial effects in the host, although a scientifically sound corroboration of these effects is not yet available for most, if not for all conditions.…”

mentioning

confidence: 99%

Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials

Pitsouni

Alexiou

Saridakis

et al. 2009

Eur J Clin Pharmacol

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Background Advances in surgery have considerably lowered postoperative morbidity. However, infection remains a considerable morbidity factor. The aim of this review is to identify the potential benefit(s) of the perioperative administration of probiotics/synbiotics to patients undergoing abdominal surgery. Methods We searched PubMed, Scopus, Web of Science, and Cochrane library to identify randomized controlled trials (RCTs) that studied the perioperative administration of probiotics/synbiotics to patients undergoing abdominal surgery. Results Nine RCTs studying 733 patients were included in our review. The incidence of postoperative pneumonia, cholangitis, and any infections as well as the duration of postoperative hospital stay and length of antibiotic therapy were lower among patients receiving probiotics than in the control group [six RCTs, 355 patients, odds ratio (OR) 0.24, 95% confidence interval (CI) 0.09-0.68; three RCTs, 209 patients, OR0.18, 95% CI0.05-0.57; seven RCTs, 514 patients, OR 0.26, 95% CI 0.12-0.55; five RCTs, 313 patients, OR −2.70, 95% CI−5.15 to −0.25; four RCTs, 250 patients, OR −4.01, 95% CI−5.11 to −2.92, respectively], while the incidence of postoperative wound infection, urinary tract infection, intra-abdominal abscess, and mortality was not different between patients of the compared groups (six RCTs, 355 patients, OR0.52, 95% CI0.23-1.18; five RCTs, 313 patients, OR0.44, 95% CI0. four RCTs, 226 patients, OR0.44, nine RCTs, 685 patients, OR0.98, respectively). Conclusion The use of probiotics/synbiotics may reduce postoperative infections after abdominal surgery. This is a promising infection-preventive measure that may decrease morbidity, length of antibiotic therapy, duration of hospital stay, and pressure for emergence of antimicrobial resistance. However, the results of this meta-analysis should be interpreted with caution due to the significant heterogeneity of the studies included.

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“…They prevent the adherence of the pathogenic bacteria to the host cells by strengthening the barrier effect of the intestinal mucosa (Eizaguirre et al 2002;Mangell et al 2002) Silva et al (1987) demonstrated an inhibitory substance produced by Lactobacillus GG with similar broad spectrum activity. They also lower the intestinal pH (De Keersmeacker et al 2006), agglutinates pathogenic microorganisms, binds and metabolise toxic metabolites (Fonden et al 2000;Oatley et al 2000;Haskard et al 2001) or regulate the intestinal motility (Marteau et al 2002) and mucus production (Mattar et al 2002;Vrese and Marteau 2007 The daily intake of L. reuteri in humans significantly reduced the number of reported sick days due to common infections, and this effect was even more pronounced in the shift workers (Tubelius et al 2005).…”

Section: Prevention Of Infectious Diseasesmentioning

confidence: 99%

Mechanism of action of probiotics

Hemaiswarya

Raja

Ravikumar

et al. 2013

Braz. arch. biol. technol.

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Probiotic supplementation reduces the risk of bacterial translocation in experimental short bowel syndrome

Cited by 81 publications

References 16 publications

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Effects of Ground Thyme and Probiotic Supplements in Diets on Broiler Performance, Blood Biochemistry and Immunological Response to Sheep Red Blood Cells

Does the use of probiotics/synbiotics prevent postoperative infections in patients undergoing abdominal surgery? A meta-analysis of randomized controlled trials

Mechanism of action of probiotics

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