Probiotic Supplements: Their Strategies in the Therapeutic and Prophylactic of Human Life-Threatening Diseases

Abstract

Chronic diseases and viral infections have threatened human life over the ages and constitute the main reason for increasing death globally. The rising burden of these diseases extends to negatively affecting the economy and trading globally, as well as daily life, which requires inexpensive, novel, and safe therapeutics. Therefore, scientists have paid close attention to probiotics as safe remedies to combat these morbidities owing to their health benefits and biotherapeutic effects. Probiotics have been broadly adopted as functional foods, nutraceuticals, and food supplements to improve human health and prevent some morbidity. Intriguingly, recent research indicates that probiotics are a promising solution for treating and prophylactic against certain dangerous diseases. Probiotics could also be associated with their essential role in animating the immune system to fight COVID-19 infection. This comprehensive review concentrates on the newest literature on probiotics and their metabolism in treating life-threatening diseases, including immune disorders, pathogens, inflammatory and allergic diseases, cancer, cardiovascular disease, gastrointestinal dysfunctions, and COVID-19 infection. The recent information in this report will particularly furnish a platform for emerging novel probiotics-based therapeutics as cheap and safe, encouraging researchers and stakeholders to develop innovative treatments based on probiotics to prevent and treat chronic and viral diseases.

Probiotic-Based Bacteriocin: Immunity Supplementation Against Viruses. An Updated Review

“…In general, eukaryotic hosts have a high bacterial load, predominantly habituating GIT ( Bibi et al, 2021 ; Youssef et al, 2021 ; Rajoka et al, 2022 ). However, some of these microorganisms are currently susceptible to pathogenesis ( Round and Mazmanian, 2009 ).…”

“…Previous studies have investigated various sources of antimicrobial agents from natural plants. Numerous antiviral agents have been proposed and verified as therapeutic targets in viral drugs ( Muhammad et al, 2018 ; Umair et al, 2020 , 2022 ; Riaz Rajoka et al, 2021 ; Senan et al, 2021 ; Youssef et al, 2021 ; Rajoka et al, 2022 ). Several treatments act as effective tools in viral infections, such as gene therapy; administration of pro- and anti-inflammatory cytokines, pegylated interferon-α (IFN-α), and ribavirin; recombinant human tumor necrosis factor-alpha (TNF-α) antagonist treatment; and highly active antiretroviral therapy, which includes multiple antiretroviral agents; or a combination of these therapies ( Lehtoranta et al, 2020 ; Lopez-Santamarina et al, 2020 ).…”

Changes in the organs and tissues of the oral cavity in the new coronavirus infection (COVID-19): A review

“…В последних обзорах отмечается, что пробиотики рассматриваются в качестве безопасных средств для борьбы с хроническими заболеваниями и вирусными инфекциями благодаря их пользе для здоровья и биотерапевтическим эффектам [59,112,113], и показания к назначению пробиотиков постоянно расширяются [59]. В этой связи S. salivarius, его штаммы К12 и М18 можно рассматривать не только в качестве средства неспецифической профилактики новой коронавирусной инфекции, но и в качестве профилактического и лечебного средства при изменениях органов и тканей полости рта при COVID-19.…”

Disorders of intestinal microbiocenosis: expanding the application of probiotics

“…В последних метаанализах отмечается, что пробиотики рассматриваются в качестве безопасных средств для Заболевания кишечника борьбы с хроническими заболеваниями и вирусными инфекциями благодаря их пользе для здоровья и биотерапевтическим эффектам [91]. Взаимодействие между осью «микрофлора -кишечник -мозг» оказывает глубокое влияние на функцию мозга, тем самым влияя на общее самочувствие человека.…”