Probiotics ameliorate alveolar bone loss by regulating gut microbiota

Jia, Leming; Tu, Ye; Jia, Xiaoyue; Du, Qian; Zheng, Xin; Yuan, Quan; Zheng, Liwei; Zhou, Xuedong; Xu, Xin

doi:10.1111/cpr.13075

Cited by 40 publications

(46 citation statements)

References 86 publications

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“…Estrogen-deficient mice exhibited pathological bone loss and impaired bone microarchitecture in femur, with downregulated gut epithelial TJ protein expression and increased serum endotoxin levels, and these pathologies could be prevented by probiotics administration ( Li J. Y. et al., 2016 ). Consistently, our previous studies observed enhanced gut permeability, elevated serum LPS, and systemic inflammation in OVX mice, consequently resulting in Th17-related immune responses in alveolar bone and aggravated periodontitis ( Jia et al., 2019 ; Jia et al., 2021 ). In addition, administration of probiotics or berberine increased gut butyrate-producing bacteria, enhanced gut barrier function with reduced circulating LPS, and thus ameliorated estrogen deficiency-induced alveolar bone loss ( Jia et al., 2019 ; Jia et al., 2021 ).…”

Section: Underlying Mechanisms Of Gut-alveolar Bone Axissupporting

confidence: 90%

“…Consistently, our previous studies observed enhanced gut permeability, elevated serum LPS, and systemic inflammation in OVX mice, consequently resulting in Th17-related immune responses in alveolar bone and aggravated periodontitis ( Jia et al., 2019 ; Jia et al., 2021 ). In addition, administration of probiotics or berberine increased gut butyrate-producing bacteria, enhanced gut barrier function with reduced circulating LPS, and thus ameliorated estrogen deficiency-induced alveolar bone loss ( Jia et al., 2019 ; Jia et al., 2021 ). Estrogen is potentially an important modulator of gut barrier.…”

Section: Underlying Mechanisms Of Gut-alveolar Bone Axissupporting

confidence: 90%

“…Obese mice showed elevated alveolar bone loss in P. gingivalis –induced periodontitis than lean mice, and gut commensal microbe A. muciniphila supplement by oral gavage significantly reduced obese-related alveolar bone loss in periodontitis ( Huck et al., 2020 ). Our previous studies reported that estrogen deficiency due to ovariectomy (OVX) led to decreased abundance of gut butyrate-producing bacteria as well as enhanced periodontal bone loss in periodontitis rats, and that berberine or probiotics supplements enriched specific gut butyrate-producing genera and prevented OVX-induced alveolar bone resorption in periodontitis, further suggesting that PMO can affect periodontitis via regulating gut microbiota ( Jia et al., 2019 ; Jia et al., 2021 ) ( Table 1 ).…”

Section: Gut Microbiota and Bone Healthmentioning

confidence: 99%

“…Additionally, estrogen can indirectly affect gut barrier by modulating gut microbiota. Estrogen deficiency induces reduction in gut butyrate-producing bacteria ( Jia et al., 2019 ; Jia et al., 2021 ). Butyrate is a beneficial bacterial metabolite that reinforces gut barrier ( Geirnaert et al., 2017 ).…”

Section: Underlying Mechanisms Of Gut-alveolar Bone Axismentioning

confidence: 99%

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Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

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Periodontitis is a polymicrobial infectious disease characterized by alveolar bone loss. Systemic diseases or local infections, such as diabetes, postmenopausal osteoporosis, obesity, and inflammatory bowel disease, promote the development and progression of periodontitis. Accumulating evidences have revealed the pivotal effects of gut microbiota on bone health via gut-alveolar-bone axis. Gut pathogens or metabolites may translocate to distant alveolar bone via circulation and regulate bone homeostasis. In addition, gut pathogens can induce aberrant gut immune responses and subsequent homing of immunocytes to distant organs, contributing to pathological bone loss. Gut microbial translocation also enhances systemic inflammation and induces trained myelopoiesis in the bone marrow, which potentially aggravates periodontitis. Furthermore, gut microbiota possibly affects bone health via regulating the production of hormone or hormone-like substances. In this review, we discussed the links between gut microbiota and periodontitis, with a particular focus on the underlying mechanisms of gut-bone axis by which systemic diseases or local infections contribute to the pathogenesis of periodontitis.

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Section: Underlying Mechanisms Of Gut-alveolar Bone Axissupporting

confidence: 90%

Section: Underlying Mechanisms Of Gut-alveolar Bone Axissupporting

confidence: 90%

Section: Gut Microbiota and Bone Healthmentioning

confidence: 99%

Section: Underlying Mechanisms Of Gut-alveolar Bone Axismentioning

confidence: 99%

See 2 more Smart Citations

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Jia

Yang

et al. 2021

Front. Cell. Infect. Microbiol.

Self Cite

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“…Probiotic Akkermansia muciniphila was revealed to reduce gingipain transcription by P. gingivalis , thereby decreasing inflammatory cell infiltration and alleviating alveolar bone loss ( Huck et al., 2020 ). Recently, we discovered that administration of probiotics enriched butyrate-producing genera of gut microbiota, improved intestinal barrier function, and decreased gut permeability, thus preventing inflammatory alveolar bone resorption in ovariectomized rats ( Jia et al., 2021 ).…”

Section: Factors That Affect Oral Microbiota-mediated Alveolar Bone Metabolismmentioning

confidence: 99%

Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

Cheng

Liu

2021

Front. Cell. Infect. Microbiol.

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Osteomicrobiology is a new research field in which the aim is to explore the role of microbiota in bone homeostasis. The alveolar bone is that part of the maxilla and mandible that supports the teeth. It is now evident that naturally occurring alveolar bone loss is considerably stunted in germ-free mice compared with specific-pathogen-free mice. Recently, the roles of oral microbiota in modulating host defense systems and alveolar bone homeostasis have attracted increasing attention. Moreover, the mechanistic understanding of oral microbiota in mediating alveolar bone remodeling processes is undergoing rapid progress due to the advancement in technology. In this review, to provide insight into the role of oral microbiota in alveolar bone homeostasis, we introduced the term “oral osteomicrobiology.” We discussed regulation of alveolar bone development and bone loss by oral microbiota under physiological and pathological conditions. We also focused on the signaling pathways involved in oral osteomicrobiology and discussed the bridging role of osteoimmunity and influencing factors in this process. Finally, the critical techniques for osteomicrobiological investigations were introduced.

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Lactobacillus plantarum AR495 improves bone health of ovariectomized mice by improving gut microbiota

Zhang,

Xia,

et al. 2024

Food Frontiers

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Osteoporosis is a common skeletal disease, especially for the bone health of menopausal women. It is reported that the changes of intestinal environment could affect the occurrence and development of osteoporosis. This study aims to explore the effects of different gut microbiota by antibiotics and bone health in ovariectomized (OVX) C57BL/6 mice and to research the anti‐osteoporosis effect of Lactobacillus plantarum AR495. The results showed that the gut microbiota could alleviate the bone mass loss after treatment of metronidazole, but the bone loss was aggravated after neomycin disturbing the microbiota. Gut microbiota significantly affected bone resorption in OVX mice by regulating intestinal barrier permeability. Through intestinal microbiological analysis, it was found that the abundance of Bifidobacterium and Eubacterium xylanophilum was positively correlated with bone health. In addition, L. plantarum AR495 could restore gut microbiota to normal level in OVX mice, increase the abundance of E. xylanophilum, reduce the expression of osteoclast promoting factors IL‐1, IL‐6, IL‐17, and TNF‐α in tibia, subsequently inhibit receptor activator of NF‐κB ligand/receptor activator of NF‐κB/osteoprotegerin (RANKL/RANK/OPG) pathway. Overall, this finding showed that L. plantarum AR495 reduces bone resorption and effectively improving osteoporosis through gut microbiota.

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Probiotics ameliorate alveolar bone loss by regulating gut microbiota

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 40 publications

References 86 publications

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Gut-Bone Axis: A Non-Negligible Contributor to Periodontitis

Oral Osteomicrobiology: The Role of Oral Microbiota in Alveolar Bone Homeostasis

Lactobacillus plantarum AR495 improves bone health of ovariectomized mice by improving gut microbiota

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