Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment

Mantegazza, Cecilia; Molinari, Paola; D’Auria, Enza; Sonnino, Micol; Morelli, L.; Zuccotti, Gian Vincenzo

doi:10.1016/j.phrs.2017.08.001

Cited by 128 publications

(93 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Antibiotics are the most often prescribed medicines for children, with more than 50% of all children <18 years old receiving at least 1 course . The most widely prescribed antibiotics are amoxicillin, azithromycin, and amoxicillin/clavulanate.…”

Section: Evidence From Human Trials: Absent Evolving or Conclusive?mentioning

confidence: 99%

“…The most widely prescribed antibiotics are amoxicillin, azithromycin, and amoxicillin/clavulanate. AAD is a very frequent side effect of antibiotic therapy, affecting approximately 11% of all children who receive antibiotics and 18% of those <2 years old . Initially, a meta‐analysis of AAD by Hempel et al included 63 RCTs and 11 811 subjects.…”

Section: Evidence From Human Trials: Absent Evolving or Conclusive?mentioning

confidence: 99%

See 1 more Smart Citation

Probiotics in Disease Prevention and Treatment

Liu

Tran

Rhoads

2018

The Journal of Clinical Pharma

170

115

View full text Add to dashboard Cite

Few treatments for human diseases have received as much investigation in the past 20 years as probiotics. In 2017, English-language meta-analyses totaling 52 studies determined the effect of probiotics on conditions ranging from necrotizing enterocolitis and colic in infants to constipation, irritable bowel syndrome, and hepatic encephalopathy in adults. The strongest evidence in favor of probiotics lies in the prevention or treatment of 5 disorders: necrotizing enterocolitis, acute infectious diarrhea, acute respiratory tract infections, antibiotic-associated diarrhea, and infant colic. Probiotic mechanisms of action include the inhibition of bacterial adhesion; enhanced mucosal barrier function; modulation of the innate and adaptive immune systems (including induction of tolerogenic dendritic cells and regulatory T cells); secretion of bioactive metabolites; and regulation of the enteric and central nervous systems. Future research is needed to identify the optimal probiotic and dose for specific diseases, to address whether the addition of prebiotics (to form synbiotics) would enhance activity, and to determine if defined microbial communities would provide benefit exceeding that of single-species probiotics.

show abstract

Section: Evidence From Human Trials: Absent Evolving or Conclusive?mentioning

confidence: 99%

Section: Evidence From Human Trials: Absent Evolving or Conclusive?mentioning

confidence: 99%

Probiotics in Disease Prevention and Treatment

Liu

Tran

Rhoads

2018

The Journal of Clinical Pharma

170

115

View full text Add to dashboard Cite

show abstract

“…The prevalence of AAD increases with duration of antibiotic intake and when different antibiotics are combined. The use of probiotic bacteria such as Saccharomyces boulardii or Lactobacillus rhamnosus GG for preventing AAD is recommended by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Working Group on Probiotics and Prebiotics as well as by recent systematic reviews . The use of L. rhamnosus GG or S. boulardii reduces the risk of AAD in approximately 50% of patients .…”

mentioning

confidence: 99%

“…Lactobacillus rhamnosus GG and S. boulardii compete with bacterial pathogens for attachment sites on intestinal cells. Subsequently, these probiotics may exert their biological activities, such as modulating the content of gut microbiota, maintaining the integrity of the intestinal barrier, preventing bacterial translocation and modulating the immune response …”

mentioning

confidence: 99%

“…The use of probiotic bacteria such as Saccharomyces boulardii or Lactobacillus rhamnosus GG for preventing AAD is recommended by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Working Group on Probiotics and Prebiotics as well as by recent systematic reviews. 5,[7][8][9] The use of L. rhamnosus GG or S. boulardii reduces the risk of AAD in approximately 50% of patients. 3,9 AAD is prevented by these probiotics through several mechanisms.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Should dental care professionals prescribe probiotics for their patients under antibiotic administration?

Aragón-Martínez

Martinez-Morales

Bologna‐Molina³

et al. 2019

International Dental Journal

View full text Add to dashboard Cite

Characterization and valorization of soybean residue (okara) for the development of synbiotic ice cream

Farooq

Mgomi

Saeed

et al. 2023

Food Science & Nutrition

View full text Add to dashboard Cite

There is an increasing challenge in probiotic viability and stability during food product formulation, processing, and storage. However, synbiotic functional foods have promising potential to deliver the targeted benefits. This study aimed to isolate the okara from soybean residue, and obtained okara flour was further characterized using Fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). Synbiotic ice cream was developed by fortification with Lactobacillus rhamnosus GG and okara at different concentrations (1–3%). Additionally, the synbiotic ice cream was subjected to physicochemical and sensory attributes over 60 days of storage. High viability of L. rhamnosus GG (8.17 log CFU/mL) was observed during storage at 3% okara. Moreover, adding okara at 2% or higher improved viscosity, reduced overrun, and maintained probiotic viability. When compared to the control (ice cream without okara), synbiotic ice cream exhibited a higher protein content and a lower fat level. The synergistic combination of probiotics and okara in ice cream is a potentially novel approach for developing functional ice cream. The addition of okara is not only helpful in increasing the nutritional value of the ice cream but will also be a way forward to minimize agricultural waste. Synbiotic ice cream developed in this study may be considered a potential functional food rich in protein and low in fat.

show abstract

Probiotics and antibiotic-associated diarrhea in children: A review and new evidence on Lactobacillus rhamnosus GG during and after antibiotic treatment

Cited by 128 publications

References 72 publications

Probiotics in Disease Prevention and Treatment

Probiotics in Disease Prevention and Treatment

Should dental care professionals prescribe probiotics for their patients under antibiotic administration?

Characterization and valorization of soybean residue (okara) for the development of synbiotic ice cream

Contact Info

Product

Resources

About