Probiotics and Child Care Absence Due to Infections: A Randomized Controlled Trial

Laursen, Rikke Pilmann; Larnkjær, Anni; Ritz, Christian; Hauger, Hanne; Michaelsen, Kim F.; Mølgaard, Christian

doi:10.1542/peds.2017-0735

Cited by 46 publications

(74 citation statements)

References 32 publications

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“…A total of 290 children were randomized, 144 to the intervention group and 146 to the placebo group. A detailed flowchart of the study recruitment is presented elsewhere . In summary, five children dropped out after randomization, but prior to baseline examination (one from the probiotic and four from the placebo group).…”

Section: Resultsmentioning

confidence: 99%

“…This could be due to the BB‐12 primer being subspecies and not strain specific, suggesting detection of endogenous Bifidobacterium animalis subsp lactis or due to prior ingestion of related strains through infant formula . From baseline to an age of 12.8 months (SD 1.4), 91 children in the placebo group used infant formulas, and of these, 26 had used formulas containing probiotics . Wider dietary restrictions were considered during planning of the study, that is, prohibiting the use of infant formulas containing prebiotics and/or probiotics, but there was concern that it would result in difficulties recruiting participants, since a majority of currently available infant formulas in Denmark contain prebiotics and/or probiotics.…”

Section: Discussionmentioning

confidence: 99%

“…A limitation of the present analysis is that sample size was based on the primary outcome of the ProbiComp study, that is, absence from day care due to infections . Despite this, we observed significant differences in the development of eczema, and regarding allergic diseases other than eczema, we probably would not have benefited from a larger sample size, since asthma, rhinitis, and conjunctivitis usually do not develop until later in childhood, and food reactions are likely to have already occurred prior to the intervention period.…”

Section: Discussionmentioning

confidence: 99%

“…The ProbiComp Study is a randomized, double‐blind, placebo‐controlled intervention trial designed to investigate the effect of probiotics on absence from day care due to respiratory or gastrointestinal infections in infants aged 8‐14 months . Inclusion period was August to December 2014 and August to December 2015.…”

Section: Methodsmentioning

confidence: 99%

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Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

Schmidt

Laursen

Bruun

et al. 2019

Pediatric Allergy Immunology

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Background Allergic diseases are common and represent a considerable health and economic burden worldwide. We aimed to examine the effect of a combination of two probiotic strains administered in late infancy and early childhood on the development of allergic diseases and sensitization. Methods In this double‐blind, placebo‐controlled intervention trial, participants were randomized to receive a daily mixture of Lactobacillus rhamnosus and Bifidobacterium animalis subsp lactis or placebo—starting prior to attending day care. The intervention period was 6 months, and the parents answered web‐based questionnaires on allergic symptoms and doctor's diagnosed allergic disease monthly. IgE was measured at baseline and follow‐up. Results A total of 290 participants were randomized: 144 in the probiotic group and 146 in the placebo group. Mean age at intervention start was 10.1 months. At follow‐up (mean age 16.1 months), the incidence of eczema was 4.2% in the probiotic group and 11.5% in the placebo group (P = 0.036). The incidence of asthma and conjunctivitis did not differ between groups, and no children presented with rhinitis. Sensitization was equal in the two groups at intervention start (7.5% and 9.5%, respectively), and two children in each group were sensitized during the intervention. Conclusions We observed a significantly lower incidence of eczema in the probiotic group compared to the placebo group. The probiotics were administered in late infancy—prior to attending day care—suggesting a broader window of opportunity using probiotics in the prevention of eczema. The incidence of asthma, rhinitis, conjunctivitis, and sensitization did not differ.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

Schmidt

Laursen

Bruun

et al. 2019

Pediatric Allergy Immunology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Another study determined that daily administration of a probiotic combination (B. animalis subsp lactis and L. rhamnosus GG) for 6 months did not reduce the number of days absent due to infections in Danish infants aged 8 to 14 months at enrollment time in child care (Laursen et al 2017).…”

Section: Probiotics and Prebiotics On Respiratory Tract Healthmentioning

confidence: 99%

Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract

et al. 2019

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The prebiotics and probiotics market is constantly growing due to the positive effects of its consumption on human health, which extends beyond the digestive system. In addition, the synbiotic products market is also expanding due to the synergistic effects between pre-and probiotics that provide additional benefits to consumers. Pre-and probiotics are being evaluated for their effectiveness to treat and prevent infectious diseases in other parts of the human body where microbial communities exist. This review examines the scientific data related to the effects of pre-and probiotics on the treatment of diseases occurring in the skin, female urogenital tract, and respiratory tract. The evidence suggests that probiotics consumption can decrease the presence of eczema in children when their mothers have consumed probiotics during pregnancy and lactation. In women, probiotics consumption can effectively prevent recurrent urinary tract infections. The consumption of synbiotic products can reduce respiratory tract infections and their duration and severity. However, the outcomes of the meta-analyses are still limited and not sufficiently conclusive to support the use of probiotics to treat infectious diseases. This is largely a result of the limited number of studies, lack of standardization of the studies, and inconsistencies between the reported results. Therefore, it is advisable that future studies consider these shortcomings and include the evaluation of the combined use of pre-and probiotics.

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Probiotics for preventing acute upper respiratory tract infections

Zhao

Dong

Qin

2022

Cochrane Database of Systematic Reviews

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Probiotics and Child Care Absence Due to Infections: A Randomized Controlled Trial

Abstract: A daily administration of a combination of subsp and for 6 months did not reduce the number of days absent from child care in healthy infants at the time of enrollment in child care.

Cited by 46 publications

References 32 publications

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

Probiotics in late infancy reduce the incidence of eczema: A randomized controlled trial

Probiotics and prebiotics potential for the care of skin, female urogenital tract, and respiratory tract

Probiotics for preventing acute upper respiratory tract infections

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