Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

Tahmasebi, Saeed; Oryan, Shahrbanoo; Mohajerani, Hamid Reza; Akbari, Neda; Palizvan, Mohammad Reza

doi:10.1016/j.yebeh.2019.106897

Cited by 37 publications

(22 citation statements)

References 51 publications

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“…In the first (acquisition) phase, each rat was allowed to freely swim for 120 s trial for four trials/day, though four consecutive days from a different quadrant aimed to find out the hidden platform, and stay for 10 s on the platform and lastly taken off. In the second (probe) phase, the rat was allowed to swim for 60 s from the same quadrant after removal of platform 53 …”

Section: Methodsmentioning

confidence: 99%

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

Badawi

Shokr

Zaki

et al. 2021

Clin Exp Pharma Physio

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Epilepsy is a chronic widely prevalent neurologic disorder, affecting brain functions with a broad spectrum of deleterious consequences. High mobility group box1 (HMGB1) is a nuclear non‐histone protein that targets vital cell receptor of toll‐like receptor 4 (TLR4) and advanced glycation end products (RAGE). HMGB1 mediated TLR4/RAGE cascade has been scored as a key culprit in neuroinflammatory signalling that critically evokes development of impaired cognition and epilepsy. The current study aimed to investigate the neuroprotective effect of pentoxifylline (PTX) on pentylenetetrazol (PTZ)‐kindling rats by its anti‐inflammatory/antioxidant capacity and its impact on memory and cognition were investigated, too. PTZ was intraperitoneally injected 35 mg/kg, every 48 h, for 14 doses, to evoke kindling model. Phenytoin (30 mg/kg, i.p.) and PTX (60 mg/kg, i.p.) or their combination were given once daily for 27 days. PTX treatment showed a statistically significant effect on behavioural, histopathological and neurochemical analysis. PTX protected the PTZ kindling rats from epileptic seizures and improved memory and cognitive impairment through the Morris water maze (MWM) test. Furthermore, PTX reversed PTZ hippocampal neuronal loss by decreasing protein expression of amyloid‐β peptide (Aβ), Tau and β site‐amyloid precursor protein cleavage enzyme 1 (BACE1), associated with a marked reduction in expression of inflammatory mediators such as HMGB1, TL4, and RAGE proteins. Furthermore, PTX inhibited hippocampal apoptotic caspase 1 protein, total reactive oxygen species (TROS) along with upregulated erythroid 2‐related factor 2 (Nrf2) content. In conclusion, PTX or its combination with phenytoin represent a promising drug to inhibit the epilepsy progression via targeting the HMGB1/TLR4/RAGE signalling pathway.

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Section: Methodsmentioning

confidence: 99%

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

Badawi

Shokr

Zaki

et al. 2021

Clin Exp Pharma Physio

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“…This study revealed that supplementation with Saccharomyces boulardii and Lactobacillus casei within the 24 hours of birth decreased 10th-fold the risk of presenting seizures in rotavirus-positive neonates [127]. Following these clinical studies, probiotic supplementation has shown favorable effects in animal models of seizures [10,37,78,109].…”

Section: Probiotic Supplementationmentioning

confidence: 81%

Gut-microbiota-directed strategies to treat epilepsy: clinical and experimental evidence

Granados

Villasana‐Salazar

Lozano-García

et al. 2021

Seizure

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“…In an animal model of AD, we showed that a cocktail of probiotics restored the impaired learning and memory in the beta amyloid (Aβ)-injected rats ( Rezaeiasl et al, 2019 ). In addition, in a series of experiments, we demonstrated that formulations of probiotics significantly improve the spatial memory examined by the Morris water maze in the ethanol treated ( Hadidi Zavareh et al, 2020 ), and the diabetic ( Davari et al, 2013 ), stressed ( Hadizadeh et al, 2019 ), and epileptic ( Bagheri et al, 2019 ; Tahmasebi et al, 2020 ) animal models.…”

Section: Probioticsmentioning

confidence: 97%

Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations

Salami

2021

Front. Neurosci.

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The human gastrointestinal tract hosts trillions of microorganisms that is called “gut microbiota.” The gut microbiota is involved in a wide variety of physiological features and functions of the body. Thus, it is not surprising that any damage to the gut microbiota is associated with disorders in different body systems. Probiotics, defined as living microorganisms with health benefits for the host, can support or restore the composition of the gut microbiota. Numerous investigations have proved a relationship between the gut microbiota with normal brain function as well as many brain diseases, in which cognitive dysfunction is a common clinical problem. On the other hand, increasing evidence suggests that the existence of a healthy gut microbiota is crucial for normal cognitive processing. In this regard, interplay of the gut microbiota and cognition has been under focus of recent researches. In the present paper, I review findings of the studies considering beneficial effects of either gut microbiota or probiotic bacteria on the brain cognitive function in the healthy and disease statuses.

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Probiotics and Nigella sativa extract supplementation improved behavioral and electrophysiological effects of PTZ-induced chemical kindling in rats

Cited by 37 publications

References 51 publications

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

Pentoxifylline prevents epileptic seizure via modulating HMGB1/RAGE/TLR4 signalling pathway and improves memory in pentylenetetrazol kindling rats

Gut-microbiota-directed strategies to treat epilepsy: clinical and experimental evidence

Interplay of Good Bacteria and Central Nervous System: Cognitive Aspects and Mechanistic Considerations

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