Probiotics and Prebiotics in Healthy Ageing

Kadam, Aayushi; Kadam, Deepak; Tungare, Kanchanlata; Shah, Heena

doi:10.1007/978-3-030-83017-5_5

Cited by 1 publication

(1 citation statement)

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“…In preclinical studies, curcumin demonstrated symptomatic reduction in some age-related diseases such as CVD, T2DM, and cancer owing to its well-known anti-inflammatory property via inhibiting NF-αB signaling ( 193 ). Other research groups have also demonstrated that Shilajit, Withaferin A, and prebiotics and probiotics can play crucial roles in the management and prevention of aging-associated immune compromise and metabolic diseases including cancer, diabetes, and obesity ( 194 , 195 ). Probiotic supplementation increased NK cell and phagocytic activity, mostly effective in elderly population.…”

Section: Immunomodulatory Nutraceuticals Toward Management Of Non-com...mentioning

confidence: 99%

Communication in non-communicable diseases (NCDs) and role of immunomodulatory nutraceuticals in their management

et al. 2022

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Conveyance of pathogens between organisms causes communicable diseases. On the other hand, a non-communicable disease (NCD) was always thought to have no causative transmissible infective agents. Today, this clear distinction is increasingly getting blurred and NCDs are found to be associated with some transmissible components. The human microbiota carries a congregation of microbes, the majority and the most widely studied being bacteria in the gut. The adult human gut harbors ginormous inhabitant microbes, and the microbiome accommodates 150-fold more genes than the host genome. Microbial communities share a mutually beneficial relationship with the host, especially with respect to host physiology including digestion, immune responses, and metabolism. This review delineates the connection between environmental factors such as infections leading to gut dysbiosis and NCDs and explores the evidence regarding possible causal link between them. We also discuss the evidence regarding the value of appropriate therapeutic immunomodulatory nutritional interventions to reduce the development of such diseases. We behold such immunomodulatory effects have the potential to influence in various NCDs and restore homeostasis. We believe that the beginning of the era of microbiota-oriented personalized treatment modalities is not far away.

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Section: Immunomodulatory Nutraceuticals Toward Management Of Non-com...mentioning

confidence: 99%