Probiotics and smectite absorbent gel formulation reduce liver stiffness, transaminase and cytokine levels in NAFLD associated with type 2 diabetes: a randomized clinical study

Kobyliak, Nazarii; Abenavoli, Ludovico; Mykhalchyshyn, Galyna; Falalyeyeva, Tetyana; Tsyryuk, Olena; Kononenko, Liudmyla; Kyriienko, Dmytro; Komisarenko, Iuliia

doi:10.5603/dk.2019.0016

Cited by 27 publications

(17 citation statements)

References 27 publications

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“…Therapy is mainly based on lifestyle changes to reduce body weight [7], and in some cases the use of metformin, glitazones, hypolipidemic drugs and TNF-a antagonists required to treat concomitant conditions [7,8]. In addition, recent studies have shown that the use of omega-3 polyunsaturated fatty acids (PUFA) can reduce liver fat content [9,10], while antioxidants [11][12][13] and probiotics [14][15][16][17] may have anti-inflammatory properties.…”

Section: Introductionmentioning

confidence: 99%

Hepatic steatosis indices as predictors of vitamin D3 deficiency in patients with NAFLD associated with type 2 diabetes

Aludwan

Kobyliak

Abenavoli

et al. 2020

Clinical Diabetology

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Background. Recently, vitamin D 3 deficiency is consi dered one of the factors associated with the develop ment of nonalcoholic fatty liver disease (NAFLD). The aim was to evaluate steatosis indices and metabolic parameters in NAFLD depending on vitamin D 3 status. Methods. According to the recommendations of the European Society of Endocrinology, all patients were divided into 3 groups: group 1-with an optimal level of vitamin D 3 (30 ng/mL); group 2-vitamin D 3 insufficiency (21-29 ng/mL) and group 3-vitamin D 3 deficiency (< 20 ng/mL). Results. The study included 126 T2D patients with NAFLD diagnosed with ultrasound. The highest hepatic steatosis (HSI) and fatty liver (FLI) index values were diagnosed in vitamin D 3 deficiency as compared to optimal group (HSI-43.34 ± 6.59 vs. 39.67 ± 4.37; P = 0.032 and FLI-79.21 ± 19.61 vs. 64.96 ± 17.72; P = 0.007). Triglyceride and glucose index (TyG) also were insignificantly elevated parallel to vitamin D 3 status worsened (P = 0.175). In multivariate logistic re gression analysis all steatosis indices were independent from transaminases activity, body mass index (BMI) and T2D duration associated with vitamin D 3 deficiency. Conclusions. Hepatic steatosis indices (HSI, FLI and TyG) independently from anthropometric parameters and transaminase activity associated with D 3 deficiency in

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Section: Introductionmentioning

confidence: 99%

Hepatic steatosis indices as predictors of vitamin D3 deficiency in patients with NAFLD associated with type 2 diabetes

Aludwan

Kobyliak

Abenavoli

et al. 2020

Clinical Diabetology

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“…Similarly, another group reported a near 33% reduction in the marker from baseline, a change that was also found to be significant compared to control ( 129 ). Through a series of four studies, Kobyliak et al ( 136 – 139 ) have reported significant changes of –5.81 ± 9.13, –7.95 ± 1.27, –5.02 ± 9.33, and –6.75 ± 7.73 pg/mL in TNF- α from baseline compared to control following multi-species probiotic supplementation.…”

Section: Resultsmentioning

confidence: 99%

The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review

et al. 2022

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BackgroundOne in 10 adults suffer from type 2 diabetes (T2D). The role of the gut microbiome, its homeostasis, and dysbiosis has been investigated with success in the pathogenesis as well as treatment of T2D. There is an increasing volume of literature reporting interventions of pro-, pre-, and synbiotics on T2D patients.MethodsStudies investigating the effect of pro-, pre-, and synbiotics on biomarkers of inflammation and oxidative stress in T2D populations were extracted from databases such as PubMed, Scopus, Web of Science, Embase, and Cochrane from inception to January 2022.ResultsFrom an initial screening of 5,984 hits, 47 clinical studies were included. Both statistically significant and non-significant results have been compiled, analyzed, and discussed. We have found various promising pro-, pre-, and synbiotic formulations. Of these, multistrain/multispecies probiotics are found to be more effective than monostrain interventions. Additionally, our findings show resistant dextrin to be the most promising prebiotic, followed closely by inulin and oligosaccharides. Finally, we report that synbiotics have shown excellent effect on markers of oxidative stress and antioxidant enzymes. We further discuss the role of metabolites in the resulting effects in biomarkers and ultimately pathogenesis of T2D, bring attention toward the ability of such nutraceuticals to have significant role in COVID-19 therapy, and finally discuss few ongoing clinical trials and prospects.ConclusionCurrent literature of pro-, pre- and synbiotic administration for T2D therapy is promising and shows many significant results with respect to most markers of inflammation and oxidative stress.

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“…By contrast, unsaturated fats reduce the risk of chronic diseases. Human studies have shown that a high-fat diet increases the abundance of total anaerobic microorganisms as well as levels of Bacteroides [67][68][69] .…”

Section: Dysbiosis and Diabetes: The Influence Of Dietmentioning

confidence: 99%

Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders

Eslami¹,

Aydınlı

Hemati

et al. 2020

Diabet Med

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In this review, the numerous possible mechanisms that provide supportive evidence for how colonic dysbiosis denotes metabolic dysfunction, dysregulates glucose homeostasis and leads to diabetes mellitus and related metabolic disorders are defined. Information was gathered from articles identified by systematic reviews and searches using Google, PubMed and Scopus. The composition of the colonic microbiota plays an integral role in maintaining host homeostasis by affecting both metabolic activities and underlying functional gene transcription in individuals with diabetes and related metabolic disorders. Increased colonic microbiome‐derived concentrations of lipopolysaccharides, also known as ‘metabolic endotoxaemia’, as well as alterations in bile acid metabolism, short‐chain fatty acids, intestinal hormones and branched‐chain amino acid secretion have been associated with the diverse production of pro‐inflammatory cytokines and the recruitment of inflammatory cells. It has been shown that changes to intestinal bacterial composition are significant even in early childhood and are associated with the pathogenesis of both types of diabetes. We hope that an improved understanding of related mechanisms linking the colonic microbiome with glucose metabolism might provide for innovative therapeutic approaches that would bring the ideal intestinal ecosystem to a state of optimal health, thus preventing and treating diabetes and related metabolic disorders.

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Probiotics and smectite absorbent gel formulation reduce liver stiffness, transaminase and cytokine levels in NAFLD associated with type 2 diabetes: a randomized clinical study

Cited by 27 publications

References 27 publications

Hepatic steatosis indices as predictors of vitamin D3 deficiency in patients with NAFLD associated with type 2 diabetes

Hepatic steatosis indices as predictors of vitamin D3 deficiency in patients with NAFLD associated with type 2 diabetes

The Promising Role of Microbiome Therapy on Biomarkers of Inflammation and Oxidative Stress in Type 2 Diabetes: A Systematic and Narrative Review

Dietary pattern, colonic microbiota and immunometabolism interaction: new frontiers for diabetes mellitus and related disorders

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