Probiotics and Their Antimicrobial Effect

Fijan, Sabina

doi:10.3390/microorganisms11020528

Cited by 20 publications

(15 citation statements)

References 27 publications

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“…Some microalgal cell components and chemical agents may exert health-promoting effects [ 47 ]. Although numerous studies regarding the antiviral effect of probiotics and the interaction of probiotics have been reported, the specific immune mechanism remained unknown [ 48 ]. Probiotics’ antiviral mechanism is still under research; however, microalgae studies are scarce.…”

Section: Discussionmentioning

confidence: 99%

Bifidobacterium longum and Chlorella sorokiniana Improve the IFN Type I-Mediated Antiviral Response in Rotavirus-Infected Cells

et al. 2023

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Probiotics are effective to treat or prevent gastrointestinal infections, and microalgae have demonstrated important health-promoting effects and in some cases function as prebiotics. In this regard, the anti-rotavirus effect of Bifidobacterium longum and Chlorella sorokiniana by reducing viral infectivity is well known. However, their effect on immune response against rotavirus has not yet been investigated. Therefore, the aim of this study was to determine the role of Bifidobacterium longum and/or Chlorella sorokiniana in influencing an IFN type I-mediated antiviral response in rotavirus-infected cells. In pre-infection experiments, HT-29 cells were treated with B. longum and C. sorokiniana alone or in combination, followed by rotavirus infection, whereas in post-infection assays, HT-29 cells were treated after infection. The cells’ mRNA was then purified to determine the relative expression level of IFN-α, IFN-β, and precursors of interferons such as RIG-I, IRF-3, and IRF-5 by qPCR. We showed that combination of B. longum and C. sorokiniana significantly increased IFN-α levels in pre-infection and IFN-β in post-infection assays, as compared with individual effects. Results indicate that B. longum, C. sorokiniana, or their combination improve cellular antiviral immune response.

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Section: Discussionmentioning

confidence: 99%

Bifidobacterium longum and Chlorella sorokiniana Improve the IFN Type I-Mediated Antiviral Response in Rotavirus-Infected Cells

et al. 2023

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“…Probiotics, particularly multi-strain probiotics (MSPs) like Bifidobacterium spp., have shown promise in preserving gut integrity and preventing GI inflammation by producing antimicrobial compounds and reinforcing the epithelial barrier [90]. The primary mode of probiotic administration is oral intake due to its benefits for antimicrobial function [91].…”

Section: Bifidobacterium-loaded Nanoparticles In the Treatment Of Inf...mentioning

confidence: 99%

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

Ghaznavi,

Hashemi,

Abolhosseini

et al. 2024

Adv. Nat. Sci: Nanosci. Nanotechnol.

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The human gastrointestinal tract is colonised by a multifaceted and dynamic population of microorganisms consisting of trillions of microbes called the gut microbiota. Through extensive research using animal models and human studies, the significant contributions of gut microbiota to immune and metabolic balance, protection against pathogens, and even neurobehavioural traits have been established. Members of the genus Bifidobacterium are the first bacteria to colonise the intestinal tract in infants, and now it has been proven that they play a positive role in enhancing the host immunity, nutrient absorption, reducing and treating gastrointestinal infections, as well as improving conditions such as diarrhea, constipation, and eczema. Bacterial nanotechnology is a rapidly growing research area with great potential for improvement and the discovery of innovations in new applications of bacteria such as Bifidobacterium. In this review, we provide an up-to-date summary of the relations of nanotechnology with Bifidobacterium in various fields, including bacterial synthesis of nanoparticles, encapsulation of bacteria, bacterial toxicity of nanomaterial, application in the field of cancer targeting, and also the treatment of other diseases such as Alzheimer’s and IBD.

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“…Probiotics, which can improve the host’s intestinal microecological balance and contain physiologically viable bacteria, have been widely used in food, health care products, drugs, and clinical treatment [ 15 ]. In order to play a probiotic role, probiotics must maintain a certain number in the gastrointestinal tract, and they adhere to the digestive tract mucosa of the human body through some specific components on the surface (colonization), rejecting the adhesion and invasion of normal cells by pathogenic bacteria [ 16 ]. Adhesion to the mucosa is the first step in colonization and proliferation.…”

Section: Introductionmentioning

confidence: 99%

A Novel Water-Soluble Polysaccharide from Daylily (Hemerocallis citrina Baroni): Isolation, Structure Analysis, and Probiotics Adhesion Promotion Effect

Ke,

Wang,

Xiao

et al. 2024

Foods

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The daylily (Hemerocallis citrina Baroni) flower is a traditional raw food material that is rich in a variety of nutrients. In particular, the content of polysaccharides in daylily is abundant and has been widely used as a functional component in food, cosmetics, medicine, and other industries. However, studies on the structure-effective relationship of daylily flower polysaccharides are still lacking. In view of this, daylily flower polysaccharides were isolated and purified, and their physical and chemical properties, structure, antioxidant activity, and adhesion-promoting effect on probiotics were evaluated. The results showed that a novel water-soluble polysaccharide (DPW) with an average molecular weight (Mw) of 2.224 kDa could be successfully isolated using column chromatography. Monosaccharide composition analysis showed that DPW only comprised glucose and fructose, with a molar ratio of 0.242:0.758. Through methylation and nuclear magnetic resonance (NMR) analysis, it was inferred that DPW belonged to the fructans group with a structure of α-D-Glcp-1→2-β-D-Fruf-1→(2-β-D-Fruf-1)n→. Antioxidant analysis showed that DPW showed strong 2-Phenyl-4,4,5,5-tetramethylimidazoline-1-oxyl-3-Oxide (PTIO-scavenging activity with IC50 of 1.54 mg/mL. DPW of 1.25 to 5 mg/mL could significantly increase the adhesion rate of Lactobacillus acidophilu, Lactobacillus casei, Bifidobacterium adolescentis, and Lactobacillus plantarum on Caco-2 cells. Considering the above results, the present study provides a theoretical basis and practical support for the development and application of daylily polysaccharides as a functional active ingredient.

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Probiotics and Their Antimicrobial Effect

Abstract: This Special Issue of the journal Microorganisms highlights the importance of the antimicrobial effect of probiotics [...]

Cited by 20 publications

References 27 publications

Bifidobacterium longum and Chlorella sorokiniana Improve the IFN Type I-Mediated Antiviral Response in Rotavirus-Infected Cells

Bifidobacterium longum and Chlorella sorokiniana Improve the IFN Type I-Mediated Antiviral Response in Rotavirus-Infected Cells

New insights into the role of nanotechnology in Bifidobacterium biomedical applications

A Novel Water-Soluble Polysaccharide from Daylily (Hemerocallis citrina Baroni): Isolation, Structure Analysis, and Probiotics Adhesion Promotion Effect

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