Probiotics as an effective therapeutic approach in alleviating depression symptoms: an umbrella meta-analysis

Musazadeh, Vali; Zarezadeh, Meysam; Faghfouri, Amir Hossein; Keramati, Majid; Jamilian, Parmida; Jamilian, Parsa; Mohagheghi, Arash; Farnam, Alireza

doi:10.1080/10408398.2022.2051164

Cited by 34 publications

(22 citation statements)

References 52 publications

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“…However, there are observable discrepancies and inconsistencies among the reported findings regarding identified bacterial genera and species, alpha and beta diversities, and the overall pattern of gut dysbiosis [ 85 ]. One commonly reported result includes a significant disturbance in the equilibria of Firmicutes and Bacteroidetes , mostly a reduced abundance of Firmicutes and an increased abundance of Bacteroidetes , Actinobacteria , and Proteobacteria [ 23 , 77 , 84 , 86 , 87 ]. Only a handful of studies exclusively explored the proportions of the phylum Firmicutes and genera Lactobacillus and Bifidobacterium in depressed subjects, providing further attestation to the reduced abundance of these hallmark members of the human gut with depression [ 88 , 89 ].…”

Section: Rudiments Of Probiotics: Human Gut Microbiota and Gut Dysbiosismentioning

confidence: 99%

“…Additionally, probiotics have favorable side-effect profiles and no associated stigma barriers [ 2 , 14 , 15 , 16 ]. The beneficial effects of probiotics on depression have been well substantiated in recent systematic reviews and meta-analyses [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Most of the existing reviews have postulated the anti-depressive effects of probiotics based on the intertwined MGBA mechanisms in the pathophysiological occurrence of depression [ 2 , 20 , 24 , 25 , 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

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A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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Probiotics are currently the subject of intensive research pursuits and also represent a multi-billion-dollar global industry given their vast potential to improve human health. In addition, mental health represents a key domain of healthcare, which currently has limited, adverse-effect prone treatment options, and probiotics may hold the potential to be a novel, customizable treatment for depression. Clinical depression is a common, potentially debilitating condition that may be amenable to a precision psychiatry-based approach utilizing probiotics. Although our understanding has not yet reached a sufficient level, this could be a therapeutic approach that can be tailored for specific individuals with their own unique set of characteristics and health issues. Scientifically, the use of probiotics as a treatment for depression has a valid basis rooted in the microbiota-gut-brain axis (MGBA) mechanisms, which play a role in the pathophysiology of depression. In theory, probiotics appear to be ideal as adjunct therapeutics for major depressive disorder (MDD) and as stand-alone therapeutics for mild MDD and may potentially revolutionize the treatment of depressive disorders. Although there is a wide range of probiotics and an almost limitless range of therapeutic combinations, this review aims to narrow the focus to the most widely commercialized and studied strains, namely Lactobacillus and Bifidobacterium, and to bring together the arguments for their usage in patients with major depressive disorder (MDD). Clinicians, scientists, and industrialists are critical stakeholders in exploring this groundbreaking concept.

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Section: Rudiments Of Probiotics: Human Gut Microbiota and Gut Dysbiosismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

Johnson

Letchumanan

Thum³

et al. 2023

Nutrients

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“…Administration of the 4-week multispecies probiotics intervention ( Bifidobacterium bifidum W23, Bifidobacterium lactis W52, Lactobacillus acidophilus W37, Lactobacillus brevis W63, Lactobacillus casei W56, Lactobacillus salivarius W24, and Lactococcus lactis W19 and W58) resulted in a significant reduction in overall cognitive reactivity to sad mood, which was largely accounted for by reduced rumination and aggressive thoughts [ 91 ]. To confirm the hypothesis that probiotics administration is associated with a significant reduction in depression, several systematic reviews and meta-analyses of the existing evidence were conducted [ 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 ]. The evidence for probiotics alleviating depressive symptoms is compelling, which is confirmed by the secondary evidence found, but additional double-blind randomized control trials in clinical populations are necessitated to further assess efficacy.…”

Section: Can Psychobiotics Minimize the Mental Health Disorders Conne...mentioning

confidence: 99%

The Role of Psychobiotics to Ensure Mental Health during the COVID-19 Pandemic—A Current State of Knowledge

Zielińska

Karbowiak

Brzezicka

2022

IJERPH

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Psychobiotics are defined as probiotics, mainly of the genus Lactobacillus and Bifidobacterium, that confer mental health benefits to the host when consumed in a particular quantity through the interaction with commensal gut microbiota. The gut microbiota, which means a diverse and dynamic population of microorganisms harboring the gastrointestinal tract, communicates with the brain and vice versa through the brain–gut axis. The mechanisms of action of psychobiotics may be divided into four groups: synthesis of neurotransmitters and neurochemicals, regulation of the HPA axis, influence on the immune system, and synthesis of metabolites. Recent years showed that the COVID-19 pandemic affected not only physical, but also mental health. Social isolation, fear of infection, the lack of adequate vaccine, disinformation, increased number of deaths, financial loss, quarantine, and lockdown are all factors can cause psychiatric problems. The aim of this review was to discuss the potential role of psychobiotic in light of the current problems, based on in vitro and in vivo studies, meta-analyses, clinical trials evidence, and registered studies assessing probiotics’ therapeutic administration in the prevention or treatment of symptoms or side effects of COVID-19.

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“…Conventionally, depression is viewed as a mental disease with physiological dysbiosis such as unbalanced neurotransmitters and neuronal circuitry, impaired neurogenesis, declined neuroplasticity, and neuroinflammation ( 7 – 9 ). Recently, growing studies identified the detrimental role of disturbed microbiota-gut-brain axis in the etiology of depression and that strategies targeting to restore the balance of this axis, namely probiotics, exert a curative effect on depression ( 10 – 12 ). The gut microbiota (GM), the gut, and the brain interact with one another reciprocally through various routes including the vagus nerve (VN) ( 13 , 14 ).…”

Section: Introductionmentioning

confidence: 99%

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

Tan¹,

Yan

et al. 2022

Front. Neurol.

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Depression is a worldwide disease causing severe disability, morbidity, and mortality. Despite abundant studies, the precise mechanisms underlying the pathophysiology of depression remain elusive. Recently, cumulate research suggests that a disturbance of microbiota-gut-brain axis may play a vital role in the etiology of depression while correcting this disturbance could alleviate depression symptoms. The vagus nerve, linking brain and gut through its afferent and efferent branches, is a critical route in the bidirectional communication of this axis. Directly or indirectly, the vagus afferent fibers can sense and relay gut microbiota signals to the brain and induce brain disorders including depression. Also, brain changes in response to stress may result in gut hyperpermeability and inflammation mediating by the vagal efferents, which may be detrimental to depression. Notably, vagus nerve stimulation owns an anti-inflammatory effect and was proved for depression treatment. Nevertheless, depression was accompanied by a low vagal tone, which may derive from response to stress and contribute to pathogenesis of depression. In this review, we aim to explore the role of the vagus nerve in depression from the perspective of the microbiota-gut-brain axis, highlighting the relationship among the vagal tone, the gut hyperpermeability, inflammation, and depression.

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Probiotics as an effective therapeutic approach in alleviating depression symptoms: an umbrella meta-analysis

Cited by 34 publications

References 52 publications

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

A Microbial-Based Approach to Mental Health: The Potential of Probiotics in the Treatment of Depression

The Role of Psychobiotics to Ensure Mental Health during the COVID-19 Pandemic—A Current State of Knowledge

Recognizing the role of the vagus nerve in depression from microbiota-gut brain axis

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