Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters

Stancu, Camelia S.; Sanda, Gabriela M.; Deleanu, Mariana; Sima, Anca V.

doi:10.1002/mnfr.201300224

Cited by 56 publications

(44 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It remains unclear whether protection against IBD afforded by probiotics or antibiotics that alter the gut microbiota extend beyond the gut. This appears likely in view of reports describing beneficial effects of oral probiotic treatment in clinical and animal studies of arthritis and cardiovascular diseases, including myocardial infarction and atherosclerosis 20–22 . The overall objective of this study was to determine whether the enhanced extra-intestinal thrombus development associated to experimental colitis (induced by dextran sodium sulfate) is altered by oral treatment with the probiotic preparation.…”

Section: Introductionmentioning

confidence: 92%

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

Souza

Senchenkova

Russell

et al. 2015

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

Several studies in IBD patients and in animal models of IBD have revealed a protective effect of probiotics in reducing clinical symptoms of disease and in blunting the gut inflammation that accompanies this condition. However, the mechanism underlying the therapeutic effect of probiotics is currently unknown. Furthermore, the ability of probiotics to influence the enhanced thrombus development that accompanies IBD has not been studied. This study addresses whether the enhanced extra-intestinal thrombosis (induced by light/dye injury) associated with experimental colitis is altered by oral treatment with the probiotic preparation VSL#3 or by the absence of microbiota. Colitis was induced by DSS 3% in Swiss Webster mice, germ free mice, C57BL/6 WT or Myd88−/− mice. In some experiments, mice received VSL#3 for 8 days before and during DSS feeding. Swiss Webster mice were also subjected to a chronic model of DSS colitis and the effect of VSL#3 was evaluated. VSL#3 treatment significantly attenuated the accelerated thrombus formation observed in both acute and chronic models of colitis. VSL#3-treated mice also exhibited attenuated inflammatory response and injury in the colon. The protective effects of VSL#3 on colitis-associated thrombogenesis and inflammation were not evident in MyD88-deficient mice. Our results suggest that improved control of the enteric microflora in IBD may afford protection against the hypercoagulable, prothrombotic state that follows this condition.

show abstract

Section: Introductionmentioning

confidence: 92%

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

Souza

Senchenkova

Russell

et al. 2015

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

show abstract

“…It is accepted that the oxidized apoAI is a marker of dysfunctional HDL . Our previous results show the presence of 4‐hydroxynonenal (4‐HNE) adducts in apoAI in HDL from HL hamsters plasma . PON1 is synthesized mainly by the liver ; however, PON1 distribution along the gastrointestinal tract in humans is under debate .…”

Section: Introductionmentioning

confidence: 99%

Hyperlipidemia‐induced hepatic and small intestine ER stress and decreased paraoxonase 1 expression and activity is associated with HDL dysfunction in Syrian hamsters

Stancu

Carnuta

Sanda

et al. 2015

Molecular Nutrition Food Res

Self Cite

View full text Add to dashboard Cite

show abstract

“…olive flounder (Paralichthys olivaceus;Hasan et al, 2019) and the common carp (Cyprinus carpio;Ghodratizadeh, Farhoudi, & Habibian, 2011) fed with probiotics. Additionally, previous studies suggested that probiotics served as hypolipidemic could improve lipid metabolism and reduce blood lipids(Stancu, Sanda, Deleanu, & Sima, 2014). Additionally, previous studies suggested that probiotics served as hypolipidemic could improve lipid metabolism and reduce blood lipids(Stancu, Sanda, Deleanu, & Sima, 2014).…”

mentioning

confidence: 99%

Dietary supplementation of Bacillus cereus as probiotics in Pengze crucian carp ( Carassius auratus var. Pengze): Effects on growth performance, fillet quality, serum biochemical parameters and intestinal histology

et al. 2019

View full text Add to dashboard Cite

This study was aimed to evaluate the effects of dietary supplementation of Bacillus cereus as probiotics on growth, fillet quality, serum biochemical parameters and intestinal histology of Pengze crucian carp (Carassius auratus var. Pengze). Fish were fed basic diet (Control group) and three diets such as CD7, CD9 and CD11 supplemented with B. cereus at dose of 107, 109 and 1011 CFU/kg for 70 days. The results showed that supplementation of 109 CFU/kg B. cereus significantly improved the growth performance compared to that in the Control group. The textures of muscle were improved by dietary supplementation of probiotics, and the hardness, gumminess, chewiness and the resilience of fish fillet increased with increasing dose of B. cereus. Total cholesterol including high‐density lipoprotein and low‐density lipoprotein level in serum decreased correspondingly with increasing level of probiotics whereas, acid phosphatase and catalase activities increased in serum. B. cereus supplementation enhanced the immunity and antioxidant capacity via an increase in acid phosphatase, alkaline phosphatase, glutathione peroxidase, reduce glutathione, and catalase, accompanied by a significant reduction in malondialdehyde. Higher intestinal fold height was observed in CD9 group than other groups. The lowest enterocyte height was exhibited in the Control group, HE values increased with increasing dose of probiotics. Moreover, dietary inclusion of B. cereus significantly affected the digestive enzymes activities in terms of higher lipase and trypase activities. In conclusion, dietary supplementation of B. cereus could promote the growth, elevate the immunity and antioxidant status of carp, and importantly improve the texture of fish fillet.

show abstract

Probiotics determine hypolipidemic and antioxidant effects in hyperlipidemic hamsters

Abstract: Our data support the administration of probiotics to humans because of their hypolipidemic (through decreasing intestinal NPC1L1 and MTTP) and antioxidant effects (stimulating HDL-associated paraoxonase-1).

Cited by 56 publications

References 45 publications

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

MyD88 Mediates the Protective Effects of Probiotics Against the Arteriolar Thrombosis and Leukocyte Recruitment Associated with Experimental Colitis

Hyperlipidemia‐induced hepatic and small intestine ER stress and decreased paraoxonase 1 expression and activity is associated with HDL dysfunction in Syrian hamsters

Dietary supplementation of Bacillus cereus as probiotics in Pengze crucian carp ( Carassius auratus var. Pengze): Effects on growth performance, fillet quality, serum biochemical parameters and intestinal histology

Contact Info

Product

Resources

About