Probiotics for the Chemoprotective Role against the Toxic Effect of Cancer Chemotherapy

Abstract

Background: The processes of chemo- and radiation therapy-based clinical management of different types of cancers are associated with toxicity and side effects of chemotherapeutic agents. So, there is always an unmet need to explore agents to reduce such risk factors. Among these, natural products have generated much attention because of their potent antioxidant and antitumor effects. In the past, some breakthrough outcomes established that various bacteria in the human intestinal gut are bearing growth-promoting attributes and suppressing the conversion of pro-carcinogens into carcinogens. Hence, probiotics integrated approaches are nowadays being explored as rationalized therapeutics in the clinical management of cancer. Methods: Here, published literature was explored to review chemoprotective roles of probiotics against toxic and side effects of chemotherapeutics. Results: Apart from excellent anti-cancer abilities, probiotics are bearing and alleviate toxicity and side effects of chemotherapeutics, with a high degree of safety and efficiency. Conclusion: Preclinical and clinical evidence suggested that due to the chemoprotective roles of probiotics against side effects and toxicity of chemotherapeutics, their integration in chemotherapy would be a judicious approach.

N-type calcium channel blockers: a new approach towards the treatment of chronic neuropathic pain

“…There are also several non-peptide small molecules under preclinical and clinical trials but till no successful outcome has been noticed. But of course, because of the small size and non-peptide nature they can lead to the development of molecule that can follow an alternate route with fewer side effects and more specific to the receptor [215][216][217][218][219][220][221]. In recent years, lots of review and research have been published on recent advancements of nanotechnology and their application on neurological disease as well as NP [222][223][224][225][226][227][228][229][230][231][232][233].…”

Roles of gut dysbiosis, anti-proliferative proteins, and post-transcriptional regulation in carcinogenesis

“…Several therapeutics are offered with which to change the composition of gut microbiota by the administration of probiotics and/or prebiotics, which could provide various benefits for the treatment of colorectal cancer [41] . In this way, probiotics have been exploited to control gut microbiota, which are defined as living microorganisms with a great health benefit on the administered individuals [42] . Probiotics could also decrease the side effects of various cancer therapies [43] .…”

Treatment opportunities with Fernandoa adenophylla and recent novel approaches for natural medicinal phytochemicals as a drug delivery system

“…The motivation behind this examination was to evaluate the muscle relaxant, antinociceptive, and atomic docking properties of an original medication named (5aR,5a1R,6R,7aS,14bR,15R) 15-hydroxy-7a-methyl-6-(2-methylprop-1-en-1-yl)-7,7a,14b,15-tetrahydro-5H-t-5a,15methanobenzo[g]benzo [5,6] azuleno[1,8-bc]-chromene-5,9,14,16(5a1H,6H)-tetraone (peshawaraquinone) was disconnected from a methanolic concentrate of FA in a creature model. The synthetic design of the detached substance was resolved utilizing progressed spectroscopic methods, which were thoroughly approved utilizing X-rays differaction (XRD) examination.…”

“…It is also cultivated as a tree, the wood is flexible, and is utilized in Burma to make bows and furniture. Its roots are used in folk medicine for piles and constipation, and as a drink for snake bites [6][7][8].…”