Probiotics for the management of neonatal hyperbilirubinemia: a systematic review of randomized controlled trials

Deshmukh, J. S.; Deshmukh, Mangesh; Patole, Sanjay

doi:10.1080/14767058.2017.1369520

Cited by 34 publications

(30 citation statements)

References 26 publications

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“…9,10 Newborns with ABO or Rh incompatibility were excluded from these studies. Deshmukh et al 11 reported that probiotic supplementation may reduce the duration of phototherapy in neonates with jaundice. These inconsistent results may be related to the doses of probiotic bacteria strains or types employed, and their ability to survive and proliferate in the intestinal environment.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization

et al. 2019

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Objective Probiotic supplementation can help to improve recovery from jaundice by reducing enterohepatic circulation through the regulation of intestinal microbial flora. The aim of our study was to investigate the effect of probiotic supplementation on neonatal hyperbilirubinemia caused by isoimmunization alone. Study Design Sixty neonates were randomly divided into a placebo group and a probiotic group (Lactobacillus rhamnosus GG). Serum total bilirubin (STB) levels were measured at birth and at 4, 8, 16, 24, and 36 hours of treatment (and at 48, 60, and 72 hours if necessary). Duration of phototherapy, rephototherapy requirements, and daily meconium evacuation were recorded. Results STB and rebound STB levels at 36 hours were lower in the probiotic group than in the placebo group (p = 0.01 and p = 0.006, respectively). Meconium evacuation was more frequent in the probiotic group than in the placebo group on the second and third days of life (p = 0.002 and 0.009, respectively). Conclusion Probiotics do not affect STB levels in the first 24 hours of life or duration of phototherapy in neonates with jaundice caused by blood group incompatibility. The effect of probiotic supplementation by reducing enterohepatic circulation occurs at 36 hours of life in newborns with isoimmunization.

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Section: Discussionmentioning

confidence: 99%

Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization

et al. 2019

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“…Neonatal jaundice is present in >50% of full-term newborns and it is more serious in late-preterm infants (1,2). Neonatal jaundice may be classed as physiological or pathological (3,4) and is principally caused by an increase in serum bilirubin during the neonatal period, which causes yellow discoloration of the skin, mucous membranes and sclerae (5). Neonatal hyperbilirubinemia is caused by an increase in blood bilirubin levels above the normal range.…”

Section: Introductionmentioning

confidence: 99%

Challenges of phototherapy for neonatal hyperbilirubinemia (Review)

Juan

Guo

et al. 2021

Exp Ther Med

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Phototherapy is universally recognized as the first option for treating neonatal jaundice due to its unparalleled efficiency and safety in reducing the high serum free bilirubin levels and limiting its neurotoxic effects. However, several studies have suggested that phototherapy may elicit a series of short- and long-term adverse reactions associated with pediatric diseases, including hemolysis, allergic diseases, DNA damage or even cancer. The aim of the present review was to summarize the etiology, mechanism, associated risks and therapeutic strategies for reducing high neonatal serum bilirubin levels. In order to shed light on the negative effects of phototherapy and to encourage implementation of a reasonable and standardized phototherapy scheme in the clinic, the present review sought to highlight the current understanding of the adverse reactions of phototherapy, as it is necessary to further study the mechanism underlying the development of the adverse effects of phototherapy in infants in order to explore novel therapeutic alternatives.

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“…In addition, studies [24] have shown that probiotic supplementation can shorten the phototherapy time of neonatal jaundice. Preventive probiotics can not signi cantly reduce the incidence of jaundice.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the Effect of Phototherapy on Intestinal Probiotics and Its Metabolism in Newborns With Jaundice

Fan

Zhang

Zheng

et al. 2021

Preprint

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Background: Both long-term and short-term side effects of phototherapy are being increasingly recognized by clinicians. The purpose of this article is to study the changes of intestinal probiotics and their metabolic indexes in newborns with jaundice receiving phototherapy. Method: Intestinal flora and metabolic changes in newborns were studied through macrogene sequencing and metabonomics. Results: We found that Bifidobacterium is the main probiotic strain present in the newborn intestinal tract, along with a small amount of Lactobacillus. Both Bifidobacterium and Lactobacillus decreased significantly (p<0.05) in neonatal intestinal flora after phototherapy for 24 hours and 48 hours. A correlation analysis between changed probiotics and intestinal short-chain fatty acid metabolites after phototherapy showed that acetic acid, butyric acid, caproic acid, and propionic acid decreased; these metabolites were significantly correlated with Bifidobacterium (p<0.05). After phototherapy, non-targeted metabolites also changed significantly (p<0.05) and were correlated with many probiotics (p<0.05). Significantly changed probiotics demonstrated a significant correlation with some intestinal non-targeted metabolites (p<0.05).Conclusion: Phototherapy can significantly affect the intestinal probiotic flora and its metabolic indicators in newborns with jaundice, which may contribute to phototherapy side effects. These findings also provide a theoretical basis for administering suitable probiotics to newborns with jaundice.

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Probiotics for the management of neonatal hyperbilirubinemia: a systematic review of randomized controlled trials

Cited by 34 publications

References 26 publications

Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization

Preventive Effects of Probiotic Supplementation on Neonatal Hyperbilirubinemia Caused by Isoimmunization

Challenges of phototherapy for neonatal hyperbilirubinemia (Review)

Analysis of the Effect of Phototherapy on Intestinal Probiotics and Its Metabolism in Newborns With Jaundice

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