Probiotics for the treatment of upper and lower respiratory‐tract infections in children: systematic review based on randomized clinical trials

Araujo, Georgia Véras de; Oliveira, Mário Henriques de; Peixoto, Décio Medeiros; Sarinho, Emanuel Sávio Cavalcanti

doi:10.1016/j.jpedp.2015.07.005

Cited by 7 publications

(6 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study population in clinical trials that found no significant effect of probiotics on VAP consisted mostly of mechanically ventilated patients, similarly to the present sample. However, other trials have shown that the use of probiotics can decrease the occurrence of infection in traumatic, surgical, and pediatric patients . Most of the patients in this trial were surgical cases.…”

Section: Discussionmentioning

confidence: 83%

Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 83%

Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Probiotic consumption decreases the risk of respiratory tract infection in children (Araujo et al 2015 ). Typical upper respiratory tract infection and certain types of influenza include the following: tonsil, pharynx, larynx, and sinuses (Eccles et al 2007 ; Thomas and Bomar 2020 ).…”

Section: Probiotic As Immune Enhancersmentioning

confidence: 99%

Role of probiotics to combat viral infections with emphasis on COVID-19

Sundararaman

Ray

Ravindra

et al. 2020

Appl Microbiol Biotechnol

151

121

View full text Add to dashboard Cite

Interspecies transmissions of viruses between animals and humans may result in unpredictable pathogenic potential and new transmissible diseases. This mechanism has recently been exemplified by the discovery of new pathogenic viruses, such as the novel severe acute respiratory syndrome corona virus-2 (SARS-CoV-2) pandemic, Middle-East respiratory syndromecoronavirus epidemic in Saudi Arabia, and the deadly outbreak of Ebola in West Africa. The. SARS-CoV-2 causes coronavirus disease-19 (COVID-19), which is having a massive global impact in terms of economic disruption, and, above all, human health. The disease is characterized by dry cough, fever, fatigue, myalgia, and dyspnea. Other symptoms include headache, sore throat, rhinorrhea, and gastrointestinal disorders. Pneumonia appears to be the most common and severe manifestation of the infection. Currently, there is no vaccine or specific drug for COVID-19. Further, the development of new antiviral requires a considerable length of time and effort for drug design and validation. Therefore, repurposing the use of natural compounds can provide alternatives and can support therapy against COVID-19. In this review, we comprehensively discuss the prophylactic and supportive therapeutic role of probiotics for the management of COVID-19. In addition, the unique role of probiotics to modulate the gut microbe and assert gut homeostasis and production of interferon as an antiviral mechanism is described. Further, the regulatory role of probiotics on gut-lung axis and mucosal immune system for the potential antiviral mechanisms is reviewed and discussed. Key points • Gut microbiota role in antiviral diseases • Factors influencing the antiviral mechanism • Probiotics and Covid-19

show abstract

“…Recent meta‐analysis was published assessing the effect of probiotics in the treatment of respiratory infections but only in children under 10 years, did not include adolescents. The authors conclude, as other reviews have been published, the need for more evidence mainly data developing countries …”

Section: Discussionmentioning

confidence: 51%

Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents

Amaral¹,

Guedes

Epifânio

et al. 2017

Pediatric Pulmonology

View full text Add to dashboard Cite

Probiotics have emerged as a promising intervention for the prevention of respiratory tract infections (RTIs) in children. Assess the effect of probiotics on prevention of RTIs in children and adolescents. MEDLINE, EMBASE, LILACS, SCIELO, CINAHL, SCOPUS, and Web of Science. Key words: "respiratory tract infections" AND probiotics. Randomized controlled trials RCT assessing the effect of probiotics on RTIs in children and adolescents were included. Two reviewers, working independently, to identify studies that met the eligibility criteria. Main and secondary outcomes were RTIs and adverse effects, respectively. Twenty-one trials with 6.603 participants were included. Pairwise meta-analysis suggested that Lactobacillus casei rhamnosus (LCA) was the only effective probiotic to the rate of RTIs compared to placebo (RR0.38; Crl 0.19-0.45). Network analysis showed that the LCA exhibited 54.7% probability of being classified in first, while the probability of Lactobacillus fermentum CECT5716 (LFC) being last in the ranking was 15.3%. LCA showed no better effect compared to other probiotic strains by indirect analysis. This systematic review found a lack of evidence to support the effect of probiotic on the incidence rate of respiratory infections in children and adolescents. Pediatr Pulmonol. 2017;52:833-843. © 2017 Wiley Periodicals, Inc.

show abstract

Probiotics for the treatment of upper and lower respiratory‐tract infections in children: systematic review based on randomized clinical trials

Cited by 7 publications

References 39 publications

Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

Effect of a Probiotic Preparation on Ventilator‐Associated Pneumonia in Critically Ill Patients Admitted to the Intensive Care Unit: A Prospective Double‐Blind Randomized Controlled Trial

Role of probiotics to combat viral infections with emphasis on COVID-19

Network meta‐analysis of probiotics to prevent respiratory infections in children and adolescents

Contact Info

Product

Resources

About