Probiotics for the treatment of bacterial vaginosis

Senok, Abiola; Verstraelen, Hans; Temmerman, Marleen; Botta, Giuseppe

doi:10.1002/14651858.cd006289.pub2

Cited by 118 publications

(67 citation statements)

References 43 publications

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“…Sometimes probiotic ‘cocktails’ comprising of various strains are used [39,40,41]. Several probiotic strains of microorganisms are effective in competing against common causes of travellers’ diarrhoea [39,42] caused mostly by bacterial pathogens such as: one of the seven types of diarrheagenic Escherichia coli , Campylobacter jejuni and Shigella species.…”

Section: Resultsmentioning

confidence: 99%

Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature

Fijan

2014

IJERPH

819

455

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Probiotics are defined as live microorganisms, which when administered in adequate amounts, confer a health benefit on the host. Health benefits have mainly been demonstrated for specific probiotic strains of the following genera: Lactobacillus, Bifidobacterium, Saccharomyces, Enterococcus, Streptococcus, Pediococcus, Leuconostoc, Bacillus, Escherichia coli. The human microbiota is getting a lot of attention today and research has already demonstrated that alteration of this microbiota may have far-reaching consequences. One of the possible routes for correcting dysbiosis is by consuming probiotics. The credibility of specific health claims of probiotics and their safety must be established through science-based clinical studies. This overview summarizes the most commonly used probiotic microorganisms and their demonstrated health claims. As probiotic properties have been shown to be strain specific, accurate identification of particular strains is also very important. On the other hand, it is also demonstrated that the use of various probiotics for immunocompromised patients or patients with a leaky gut has also yielded infections, sepsis, fungemia, bacteraemia. Although the vast majority of probiotics that are used today are generally regarded as safe and beneficial for healthy individuals, caution in selecting and monitoring of probiotics for patients is needed and complete consideration of risk-benefit ratio before prescribing is recommended.

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Section: Resultsmentioning

confidence: 99%

Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature

Fijan

2014

IJERPH

819

455

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“…Likewise, probiotic therapies may have some utility in the prevention of recurrent BV, particularly if combined with an effective antibiotic therapy that will destabilise the pathologic flora, although larger-scale clinical trials are needed. 109 Clearly Koch's postulates have provided a benchmark for studies of microbial pathogenicity and their relevance has survived over a century of scientific progress. 1 Indeed, it is possible organisms remain to be discovered that satisfy these postulates with regard to the aetiology of some apparently polymicrobial diseases.…”

Section: Resultsmentioning

confidence: 99%

Polymicrobial challenges to Koch’s postulates: Ecological lessons from the bacterial vaginosis and cystic fibrosis microbiomes

et al. 2012

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Koch's postulates have shaped our understanding of infectious diseases; however, one of the tangential consequences of them has been the emergence of a predominantly monomicrobial perspective concerning disease aetiology. This orthodoxy has been undermined by the growing recognition that some important infectious diseases have a polymicrobial aetiology. A significant new development in our understanding of polymicrobial infections is the recognition that they represent functional ecosystems and that to understand such systems and the outcome and impact of therapeutic interventions requires an understanding of how these communities arise and develop. Therefore, it is timely to explore what we can learn from other fields. In particular, ecological theory may inform our understanding of how polymicrobial communities assemble their structure and their dynamics over time. Such work may also offer insights into how such communities move from stable to unstable states, as well as the role of invasive pathogens in the progression of the disease. Ecological theory offers a theoretical framework around which testable hypotheses can be developed to clarify the polymicrobial nature and dynamics of such infections in the face of environmental change and therapeutic interventions.

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“…Though no proper in-vitro model of the bacterial vaginosis film at present exists, it is worth mentioning that a recent series of experiments do suggest that probiotics may have a place as an adjuvant to antibiotic therapy in treating bacterial vaginosis as has been found in clinical studies [17]. McMillan et al [18 && ] grew a 12-mm thick confluent A. vaginae and G. vaginalis biofilm, which they evaluated for changes occurring with antibiotic and probiotic treatment.…”

Section: Implications For the Treatment Of Bacterial Vaginosismentioning

confidence: 99%