Probiotics for treating infectious diarrhoea

Allen, SJ; Okoko, Brown J.; Martinez, Elizabeth G; Gregorio, Germana V.; Dans, LF

doi:10.1002/14651858.cd003048

Cited by 109 publications

(133 citation statements)

References 14 publications

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“…This low activity of probiotics treatment is surprising in regard to previous published data on the beneficial effect of some probiotics on infectious diarrhoea (Szajewska and Mrukowicz 2001;Allen et al 2004;Picard et al 2005) and the use of a treatment dosage that proved efficient in a neonatal rat model of rotavirus-induced diarrhoea (GuerinDanan et al 2001). However, data are very limited for parasitic diarrhoea and rather concern extracellular parasites such as Giardia.…”

Section: Discussionmentioning

confidence: 92%

Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats

Guitard¹,

Menotti

Desveaux

et al. 2006

Parasitol Res

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To date, there is no efficient treatment for cryptosporidiosis and parasite eradication relies on innate and acquired immunity. In this study, we investigated the effect of administration of probiotic bacteria on the development and progression of the experimental infection in suckling rats. Rats were fed daily with 2.10(7) CFU of Lactobacillus casei-containing mixture, starting 2 days before the infection until the spontaneous clearance of the parasite. Effects on weight gain, parasite burden, mucosal histology and production of mucosal cytokines (IFNgamma, IL10 and TNFalpha) were studied. Although a trend to a more rapid clearance of parasites was noted in rats treated with probiotics, no significant effect of probiotics administration was observed in terms of weight gain, parasite burden, mucosal damage, or kinetics of mucosal cytokines during the course of infection. Overall, our results showed that the daily administration of L. casei-containing mixtures was unable to eradicate the parasite in our model.

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Section: Discussionmentioning

confidence: 92%

Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats

Guitard¹,

Menotti

Desveaux

et al. 2006

Parasitol Res

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“…The efficacy of Lactobacillus GG appeared related to the logarithm of the dose (>10 11 as the most efficient dose) [69]. A Cochrane review examined 23 RCTs and 1,917 participants (1,449 children) and highlighted the beneficial effect of probiotics as an add-on treatment to ORS in reducing the duration of diarrhoea (of about 30 hours with an RR 0.7) without significant side effects in immunecompetent subjects [3]. Regarding the other bacterial strains evaluated (Streptococcus thermophilus, L.acidophilus and bulgaricus) more studies are needed [3].…”

Section: Treatment Of Infectious Gastroenteritismentioning

confidence: 99%

“…Regarding the other bacterial strains evaluated (Streptococcus thermophilus, L.acidophilus and bulgaricus) more studies are needed [3]. More studies on the mechanisms of action in clinical situations are also needed [3]. Shamir and coworkers showed a reduction in duration of acute gastroenteritis from 1.96±1.24 to 1.43± 0.71 days (p=0.017) with the addition of 10 9 CFU Streptococcus thermophilus, B. lactis, L. acidophilus, 10 mg zinc and 0.3 gram fructo-oligosaccharides per day [54].…”

Section: Treatment Of Infectious Gastroenteritismentioning

confidence: 99%

“…Most studies show a statistically significant effect that is of only moderate clinical benefit, with the greatest effect in viral and watery diarrhea [61]. In general, meta-analyses of published trials conclude in a reduction of diarrhoeal duration of approximately 24 hours (17-30 hours) for selected strains of lactobacilli (such as L. casei GG, L. acidophilus, L. Bulgaricus and L. reuteri) and S. boulardii [3,27,53,59,61,63,69]. One should be aware that the available literature is biased since not all negative trials are reported.…”

Section: Treatment Of Infectious Gastroenteritismentioning

confidence: 99%

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Probiotics in infectious diarrhoea in children: are they indicated?

et al. 2007

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Infectious gastroenteritis continues to be a leading cause of mortality and morbidity worldwide. The cornerstone of treatment remains replacement of water and electrolyte losses with oral rehydration solution. Until a few years ago, probiotics were discussed primarily in the context of alternative medicine, but they are now entering mainstream medical practice since a decrease of the severity and duration of infectious gastroenteritis in approximately 24 hours has been shown for some strains. Therefore, probiotics are a potential add-on therapy in acute gastro-enteritis. The shortening of the duration of diarrhoea and the reduction in hospital stay result in a social and economic benefit. Evidence found in viral gastroenteritis is more convincing than in bacterial or parasitic infection. Mechanisms of action are strain specific and only those commercial products for which there is evidence of clinical efficacy should be recommended. Timing of administration is also of importance. In acute gastroenteritis, there is evidence for efficacy of some strains of lactobacilli (e.g. Lactobacillus caseii GG and Lactobacillus reuteri) and for Saccharomyces boulardii. Probiotics are "generally regarded as safe", but side effects such as septicaemia and fungaemia have very rarely been reported in high-risk situations. Although most studies conclude in a statistically significant shortening of the duration of diarrhea, the clinical relevance of this finding is limited. In conclusion, selected strains of probiotics result in a statistically significant but clinically moderate benefit in shortening the duration of diarrhoea caused by acute infectious gastroenteritis.

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“…LGG scheint in der Behandlung von Rotavirusenteritiden besonders wirkungsvoll zu sein [1,33]. Die meisten in den Metaanalysen untersuchten Studien wurden in entwickelten Ländern durchgeführt.…”

Section: Behandlung Mit Probiotikaunclassified

Probiotics in children and adolescents with gastrointestinal disease

Liptay

Burdach

2008

Monatsschr Kinderheilkd

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Leitthema Der Einsatz von Probiotika wurde in den vergangenen Jahren nicht zuletzt durch eine breite Medienaufmerksamkeit zunehmend populär. Zu unterscheiden sind Nahrungsergänzungsmittel, die keiner strengen arzneimittelrechtlichen Kontrolle unterliegen und häufig andere oder weit weniger Keime als angegeben enthalten, von geprüften Medikamenten. Eingesetzt werden Probiotika bei zahlreichen gastroenterologischen Erkrankungen. Ihre Wirksamkeit ist jedoch nur bei einigen wenigen Indikationen wissenschaftlich nachgewiesen. > Lactobacillus zeigt in der Behandlung der Diarrhö positive Effekte Trotz der oben aufgeführten Heterogenität der Studien wurden in den letzten Jahren mehrere Metaanalysen [1, 33, 36] veröffent-licht, die alle einen statistisch signifikanten, Redaktion M.J. Lentze, Bonn

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Probiotics for treating infectious diarrhoea

Cited by 109 publications

References 14 publications

Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats

Experimental study of the effects of probiotics on Cryptosporidium parvum infection in neonatal rats

Probiotics in infectious diarrhoea in children: are they indicated?

Probiotics in children and adolescents with gastrointestinal disease

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