Probiotics for vulvovaginal candidiasis in non-pregnant women

Xie, Huan; Feng, Dan; Dong, Wei; Mei, Ling; Chen, Hui; Wang, Xun; Fang, Fang

doi:10.1002/14651858.cd010496.pub2

Cited by 71 publications

(48 citation statements)

References 62 publications

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“…It is imperative that the restoration of vaginal microbiota could prevent various vaginal infections and the rate of its recurrence. According to Xie et al [ 174 ], there are insufficient shreds of evidence to recommend the usage of only probiotics in countering VVC and BV as compared to conventional drugs treatment.…”

Section: Potential Of Lactobacillus In Keeping Vagmentioning

confidence: 99%

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

2020

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Human vagina is colonised by a diverse array of microorganisms that make up the normal microbiota and mycobiota. Lactobacillus is the most frequently isolated microorganism from the healthy human vagina, this includes Lactobacillus crispatus, Lactobacillus gasseri, Lactobacillus iners, and Lactobacillus jensenii. These vaginal lactobacilli have been touted to prevent invasion of pathogens by keeping their population in check. However, the disruption of vaginal ecosystem contributes to the overgrowth of pathogens which causes complicated vaginal infections such as bacterial vaginosis (BV), sexually transmitted infections (STIs), and vulvovaginal candidiasis (VVC). Predisposing factors such as menses, pregnancy, sexual practice, uncontrolled usage of antibiotics, and vaginal douching can alter the microbial community. Therefore, the composition of vaginal microbiota serves an important role in determining vagina health. Owing to their Generally Recognised as Safe (GRAS) status, lactobacilli have been widely utilised as one of the alternatives besides conventional antimicrobial treatment against vaginal pathogens for the prevention of chronic vaginitis and the restoration of vaginal ecosystem. In addition, the effectiveness of Lactobacillus as prophylaxis has also been well-founded in long-term administration. This review aimed to highlight the beneficial effects of lactobacilli derivatives (i.e. surface-active molecules) with anti-biofilm, antioxidant, pathogen-inhibition, and immunomodulation activities in developing remedies for vaginal infections. We also discuss the current challenges in the implementation of the use of lactobacilli derivatives in promotion of human health. In the current review, we intend to provide insights for the development of lactobacilli derivatives as a complementary or alternative medicine to conventional probiotic therapy in vaginal health.

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Section: Potential Of Lactobacillus In Keeping Vagmentioning

confidence: 99%

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

2020

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“…The recognized favorable effect of probiotic administration for the BV and VVC treatments has been evaluated in numerous meta-analysis [177][178][179][180] and recently reviewed in [176]. Relative to VVC, it is estimated that approximately seven women out of ten women will live at least one experience of VVC in their lives [181], where recurrence is quite often.…”

Section: Probiotics In Non-pregnant Womenmentioning

confidence: 99%

“…This fact has made probiotics a real option to be considered together with current antifungal therapies. In a Cochrane systematic review [180], the efficiency of probiotic treatment for VVC in non-pregnant women was recently under evaluation. The conclusions from 10 randomized controlled trial (RCTs) (1656 participants) studying the influence of probiotics used by oral and vaginal routes, as a coadjuvant therapy to antifungal drugs, were that probiotics slightly enhanced the temporary clinical and mycological cure rate and reduced the 1 month relapse rate.…”

Section: Probiotics In Non-pregnant Womenmentioning

confidence: 99%

Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis

et al. 2020

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The vaginal microbiota has importance in preserving vaginal health and defending the host against disease. The advent of new molecular techniques and computer science has allowed researchers to discover microbial composition in depth and associate the structure of vaginal microbial communities. There is a consensus that vaginal flora is grouped into a restricted number of communities, although the structure of the community is constantly changing. Certain Community-State Types (CSTs) are more associated with poor reproductive outcomes and sexually transmitted diseases (STDs) meanwhile, CSTs dominated by Lactobacillus species—particularly Lactobacillus crispatus—are more related to vaginal health. In this work, we have reviewed how modifiable and non-modifiable factors may affect normal vaginal microbiota homeostasis—including sexual behavior, race or ethnicity, and hygiene. Special interest has been given to how the use of probiotics, diet intake, and use of hormone replacement therapies (HRTs) can potentially impact vaginal microbiota composition.

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“…Adjunctive treatment does not seem to influence the rate of long‐term (within 1 to 3 months) clinical cure, long‐term mycological cure, serious and non‐serious side events. Up to the present, due to the low quality of data available, there is insufficient evidence for the use of probiotics either as adjuvants to conventional antifungal medicines or used alone for the treatment of VVC in non‐pregnant women …”

Section: Introductionmentioning

confidence: 99%

Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment

Russo¹,

Superti²,

Karadja

et al. 2019

Mycoses

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Summary Background Vulvovaginal candidiasis (VVC) is a recurrent vaginal condition in childbearing women. Objectives The aim of this study was to assess the efficacy of an oral formulation containing Lactobacillus acidophilus GLA‐14, Lactobacillus rhamnosus HN001 and bovine lactoferrin on symptoms and recurrence of VVC as adjuvant therapy to topical clotrimazole. Patients/Methods Forty‐eight women positive for C. albicans, symptoms of VVC and documented history of recurrences were randomised into 2 groups receiving verum or placebo (2 capsules/day for 5 days followed by 1 capsule/day for additional 10 days) as adjuvant treatment to clotrimazole (induction phase) followed by a maintenance cycle of 6 months (1 capsule/day verum or placebo for 10 consecutive days each month). Symptoms, overall cure rate and recurrence rate were assessed. Results After clotrimazole therapy, a significant improvement of symptoms was shown in both groups. However, only women treated with probiotics and lactoferrin showed a significant improvement of itching and discharge at 3 and 6 months. During the six‐month follow‐up, recurrences were significantly less in the intervention group vs placebo (33.3% vs 91.7% after 3 months and 29.2% vs 100% after 6 months). Conclusions The results show that the investigated lactobacilli mixture in combination with lactoferrin represents a safe and effective adjuvant approach for reducing symptoms and recurrences of RVVC.

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Probiotics for vulvovaginal candidiasis in non-pregnant women

Abstract: Analysis 1.2. Comparison 1 Probiotics plus conventional antifungal drugs versus conventional antifungal drugs, Outcome 2 Clinical cure rate (short-term): sensitivity analysis.

Cited by 71 publications

References 62 publications

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

Vaginal microbiota and the potential of Lactobacillus derivatives in maintaining vaginal health

Reviewing the Composition of Vaginal Microbiota: Inclusion of Nutrition and Probiotic Factors in the Maintenance of Eubiosis

Randomised clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment

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