Probiotics (<i>Bifidobacterium, Lactobacillus, and Saccharomyces boulardii</i>): An Evidence-Based Systematic Review by the Natural Standard Research Collaboration

UlbrichtCatherine,; BudimanTantri,; ChaoWendy,; Tanguay-ColucciShaina,; ConquerJulie,; CostaDawn,; IsaacRichard,; ParriottJoseph,; RandhawaAmarita,; RusieErica,; SerranoJill, M Grimes; VargheseMinney,; WoodsJen,; ZhouSara,

doi:10.1089/act.2011.17601

Cited by 1 publication

(1 citation statement)

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“…It has been shown that the use of probiotics in several patients with chemotherapy-induced is safe, leads to a decrease in the severity of diarrhea, and prevents body weight loss, therefore it is recommended to be used clinically by cancer patients [ 24 – 27 ]. Since the immune system of patients receiving chemotherapy is severely weakened, it is a crucial point that the use of probiotics may increase the risk of infection and this should be considered when preparing the treatment [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

An experimental study: the effect of S. boulardii on abemaciclib-induced diarrhea

CAKCAK¹,

AYTİN²,

SAYIN³

et al. 2023

Turkish Journal of Medical Sciences

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Background/aim In our study, we aimed to investigate the protective effects of Saccharomyces boulardii on abemaciclib-induced diarrhea model, which is a commonly used drug in breast cancer. Materials and methods Thirty rats were divided into 3 groups as control (Group 1), abemaciclib (Group 2), and abemaciclib + Saccharomyces boulardii (Group 3) groups. The clinical status, body weight, and defecation status were monitored daily. At the end of the 15-day experiment period, the rats were killed with high-dose anesthesia and the resected small intestine segments were evaluated histopathologically. Lesions were classified according to thickening of the villus, inflammation and edema of mucosa and intraepithelial leukocyte accumulation. Then, mean values of both crypt depths and villi thicknesses were calculated for each rat. Normal distribution assumption was controlled with the Shapiro-Wilk test. One-way analysis of variance for normally distributed variables in the comparisons of more than two independent groups and Kruskal-Wallis test for nonnormally distributed variables were used. The significance value was accepted as 0.05. Results There was one death in Group 3, but none in the others. There were no findings of mucositis in Group I. There was mild diarrhea and weight loss in only one rat in Group 1. For the comparison of the severity of diarrhea (72.5%/39%) and weight loss (72.5%/45%), a decrease was found in Group 3 according to Group 2 (p < 0.01). Histopathological findings such as edema, inflammation, and intraepithelial leukocyte accumulation also showed a decrease in Group 3 compared to Group 2 (p < 0.01). Conclusion Saccharomyces boulardii should be considered as a treatment option in abaemaciclib (chemotherapy)-induced diarrhea. Further comparative studies and in vivo human randomized controlled studies can be conducted in the future.

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Section: Discussionmentioning

confidence: 99%