Probiotics Improve Gastrointestinal Function and Life Quality in Pregnancy

Abstract

We studied whether probiotics were beneficial for hormonal change-associated dysbiosis, which may influence the enteric nervous system and GI function during early pregnancy. The study was 16 days consisting of two cycles of six daily probiotics mainly Lactobacillus and 2 days without probiotics. Daily surveys were conducted to monitor GI function and life quality. A subset of the participants who contributed fecal specimens was used for microbiota metagenomic sequencing, metabolomics, and quantification of bacterial genes to understand potential underlying mechanisms. Statistical analyses were done by generalized linear mixed-effects models. Thirty-two obstetric patients and 535 daily observations were included. The data revealed that probiotic supplementation significantly reduced the severity of nausea, vomiting, constipation, and improved life quality. Moreover, a low copy number of fecal bsh (bile salt hydrolase), which generates free bile acids, was associated with high vomiting scores and probiotic intake increased fecal bsh. In exploratory analysis without adjusting for multiplicity, a low fecal α-tocopherol, as well as a high abundance of Akkemansia muciniphila, was associated with high vomiting scores and times, respectively. The potential implications of these biomarkers in pregnancy and GI function are discussed. Probiotics likely produce free bile acids to facilitate intestinal mobility and metabolism.

Effect of Mothers’ Application of Yogurt Probiotic Bacteria on Relieving their young Children’s Acute Gastroenteritis

“…This could be explained in the light of, the probiotic intake increased the level of Bile Salt Hydrolase generating bacteria, which produced free bile acids that enhancing gastrointestinal motility and metabolism and it also have the antiinflammatory and metabolic effects (Săsăran, 2023;Bourgin et al,2021). Liu et al, (2021) who studied the effect of probiotics on improvement of gastrointestinal function also support the results of the present study were mentioned that probiotic intake significantly reduced frequency of vomiting. The findings that have been shown by Yossef et al, (2019) were also congruent with these results were stated that probiotics produced highly statistically significant improvement in gastrointestinal symptoms.…”

Impact of Gut–Brain Axis on Hepatobiliary Diseases in Fetal Programming

“…Administration of probiotic enteric-coated capsules in combination with ursodeoxycholic acid soft capsules to 82 ICP patients increased alkaline phosphatase (ALP) and γ-glutamyltransferase (γ-GT) enzyme levels and decreased blood ammonia (BA) levels. These effectively improved the liver function and intestinal flora of ICP patients [90]. Another probiotic, L. rhamnosus LRX01, was found to inhibit the expression of FXR in the ileum of pregnant ICP patients.…”

Targeting gut microbial bile salt hydrolase (BSH) by diet supplements: new insights into dietary modulation of human health

“…94 One study conducted in pregnant women showed that probiotic could increase the copy numbers of bsh, which were notably correlated with lower vomiting scores and times. 95 TCA is a powerful trigger for Clostridioides difficile infection, while BSH can hydrolyse TCA to cholic acid, which can inhibit the growth of C. difficile. 96 Some BAs are toxic due to their acidic properties and detergent-like properties, BSH enzyme can promote deconjugation of conjugated BAs and eliminate their inherent detergent properties.…”

“…94 One study conducted in pregnant women showed that probiotic could increase the copy numbers of bsh , which were notably correlated with lower vomiting scores and times. 95 TCA is a powerful trigger for Clostridioides difficile infection, while BSH can hydrolyse TCA to cholic acid, which can inhibit the growth of C. difficile. 96…”