Probiotics improve polystyrene microplastics-induced male reproductive toxicity in mice by alleviating inflammatory response

Zhang, Yecui; Hou, Baolian; Liu, Tao; Wu, Yue; Wang, Zhiping

doi:10.1016/j.ecoenv.2023.115248

Cited by 24 publications

(3 citation statements)

References 65 publications

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“…For example, studies have found that sperm motility in Duroc pigs can be improved by the gut microbiota, especially Rikenellaceae (Li et al, 2022b). Probiotic supplements are effective in repairing spermatogenic impairment (Zhang et al, 2023). Most of these effects are mediated by metabolites produced by the gut microbiota.…”

Section: Gut Microbiota Change Sperm Qualitymentioning

confidence: 99%

“…Probiotics are live bacteria that offer a range of potential health benefits to the human body. Oral supplementary probiotics, Lactobacillus, Bifidobacterium, Enterococcus, Collinsella, and Blautia, can enhance sperm quality by alleviating sperm inflammatory response and oxidative stress (Helli et al, 2022;Cao et al, 2023;Zhang et al, 2023). These may be linked to probiotics can regulate the Nrf2-Keap1-ARE signaling pathway to increase antioxidant activity and enhance neutralization of reactive oxygen species, ultimately resulting in improved sperm concentration and motility in infertile men (Helli et al, 2022).…”

Section: Probioticsmentioning

confidence: 99%

“…Taxifolin also improved semen quality by improving gut microbes and blood metabolites in Duroc boars (Zhou et al, 2022). Lactobacillus, Bifidobacterium, and Enterococcus can enhance sperm quality by alleviating inflammatory response (Zhang et al, 2023). One the other hand, gut dysbiosis can also disrupt reproductive function.…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota is involved in male reproductive function: a review

Lv,

Huang,

Luo

et al. 2024

Front. Microbiol.

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Globally, ~8%−12% of couples confront infertility issues, male-related issues being accountable for 50%. This review focuses on the influence of gut microbiota and their metabolites on the male reproductive system from five perspectives: sperm quality, testicular structure, sex hormones, sexual behavior, and probiotic supplementation. To improve sperm quality, gut microbiota can secrete metabolites by themselves or regulate host metabolites. Endotoxemia is a key factor in testicular structure damage that causes orchitis and disrupts the blood-testis barrier (BTB). In addition, the gut microbiota can regulate sex hormone levels by participating in the synthesis of sex hormone-related enzymes directly and participating in the enterohepatic circulation of sex hormones, and affect the hypothalamic-pituitary-testis (HPT) axis. They can also activate areas of the brain that control sexual arousal and behavior through metabolites. Probiotic supplementation can improve male reproductive function. Therefore, the gut microbiota may affect male reproductive function and behavior; however, further research is needed to better understand the mechanisms underlying microbiota-mediated male infertility.

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Section: Gut Microbiota Change Sperm Qualitymentioning

confidence: 99%

Section: Probioticsmentioning

confidence: 99%