Probiotics in Health and Disease: Distinct Roles of Different Strains in Natural Killer Cell Activation and Regulation

Kaur, Kawaljit; Ko, Meng-Wei; Chen, Po-Chun; Breznik, Barbara; Senjor, Emanuela; Wong, Paul; Wang, Yuhao; Chovatiya, Nishant; Jewett, Anahid

doi:10.1615/critrevimmunol.2021037163

Cited by 5 publications

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“…This technique involves the activation of peripheral blood-derived NK cells with a combination of IL-2 and anti-CD16 mAbs, and co-culturing of activated NK cells with osteoclasts (OCs) as feeder cells in the presence of probiotics sAJ2, this process leads to expansion and highly functional activation of NK cells [ 103 , 128 , 129 ]. Due to their superior anti-cancer activity, these cells were named supercharged NK (sNK) cells [ 15 , 16 , 86 , 103 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ] ( Table 1 and Figure 2 ). sNK cells were found to be highly effective against tumors in preclinical models [ 15 , 16 , 86 , 103 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ].…”

Section: Supercharged Nk Cells As An Effective Strategy To Eliminate ...mentioning

confidence: 99%

“…Due to their superior anti-cancer activity, these cells were named supercharged NK (sNK) cells [ 15 , 16 , 86 , 103 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ] ( Table 1 and Figure 2 ). sNK cells were found to be highly effective against tumors in preclinical models [ 15 , 16 , 86 , 103 , 128 , 129 , 130 , 131 , 132 , 133 , 134 , 135 , 136 ]. The rationale for using OCs for this methodology was the secretion of a wide range of cytokines and chemokines including IL-12, IL-15, IFN-a, and IL-18 by OCs, which are known to increase NK function.…”

Section: Supercharged Nk Cells As An Effective Strategy To Eliminate ...mentioning

confidence: 99%

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Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

Kaur,

Sanghu,

Memarzadeh

et al. 2024

Vaccines

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High-grade serous ovarian cancers (HGSOCs) likely consist of poorly differentiated stem-like cells (PDSLCs) and differentiated tumor cells. Conventional therapeutics are incapable of completely eradicating PDSLCs, contributing to disease progression and tumor relapse. Primary NK cells are known to effectively lyse PDSLCs, but they exhibit low or minimal cytotoxic potential against well-differentiated tumors. We have introduced and discussed the characteristics of super-charged NK (sNK) cells in this review. sNK cells, in comparison to primary NK cells, exhibit a significantly higher capability for the direct killing of both PDSLCs and well-differentiated tumors. In addition, sNK cells secrete significantly higher levels of cytokines, especially those known to induce the differentiation of tumors. In addition, we propose that a combination of sNK and chemotherapy could be one of the most effective strategies to eliminate the heterogeneous population of ovarian tumors; sNK cells can lyse both PDSLCs and well-differentiated tumors, induce the differentiation of PDSLCs, and could be used in combination with chemotherapy to target both well-differentiated and NK-induced differentiated tumors.

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Section: Supercharged Nk Cells As An Effective Strategy To Eliminate ...mentioning

confidence: 99%

Section: Supercharged Nk Cells As An Effective Strategy To Eliminate ...mentioning

confidence: 99%

Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

Kaur,

Sanghu,

Memarzadeh

et al. 2024

Vaccines

Self Cite

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Immunotherapy: an alternative promising therapeutic approach against cancers

et al. 2022

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The immune system interacts with cancer cells in multiple intricate ways that can shield the host against hyper-proliferation but can also contribute to malignancy. Understanding the protective roles of the immune system in its interaction with cancer cells can help device new and alternate therapeutic strategies. Many immunotherapeutic methodologies, including adaptive cancer therapy, cancer peptide vaccines, monoclonal antibodies, and immune checkpoint treatment, have transformed the traditional cancer treatment landscape. However, many questions remain unaddressed. The development of personalized combination therapy and neoantigen-based cancer vaccines would be the avant-garde approach to cancer treatment. Desirable chemotherapy should be durable, safe, and target-specific. Managing both tumor (intrinsic factors) and its microenvironment (extrinsic factors) are critical for successful immunotherapy. This review describes current approaches and their advancement related to monoclonal antibody-related clinical trials, new cytokine therapy, a checkpoint inhibitor, adoptive T cell therapy, cancer vaccine, and oncolytic virus. Supplementary Information The online version contains supplementary material available at 10.1007/s11033-022-07525-8.

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Supercharged NK Cell-Based Immuotherapy in Humanized Bone Marrow Liver and Thymus (Hu-BLT) Mice Model of Oral, Pancreatic, Glioblastoma, Hepatic, Melanoma and Ovarian Cancers

Kaur,

Jewett

2023

Crit Rev Immunol

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In this paper, we review a number of in vitro and in vivo studies regarding the efficacy of supercharged NK (sNK) cell therapy in elimination or treatment of cancer. We have performed studies using six different types of cancer models of oral, pancreatic, glioblastoma, melanoma, hepatic and ovarian cancers using hu-BLT mice. Our in vitro studies demonstrated that primary NK cells preferentially target cancer stem-like cells (CSCs)/poorly differentiated tumors whereas sNK cells target both CSCs/poorly-differentiated and well-differentiated tumors significantly higher than primary activated NK cells. Our in vivo studies in humanized-BLT mice showed that sNK cells alone or in combination with other cancer therapeutics prevented tumor growth and metastasis. In addition, sNK cells were able to increase IFN-γ secretion and cytotoxic function by the immune cells in bone marrow, spleen, gingiva, pancreas and peripheral blood. Furthermore, sNK cells were able to increase the expansion and function of CD8+ T cells both in in vitro and in vivo studies. Overall, our studies demonstrated that sNK cells alone or in combination with other cancer therapeutics were not only effective against eliminating aggressive cancers, but were also able to increase the expansion and function of CD8+ T cells to further target cancer cells, providing a successful approach to eradicate and cure cancer.

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Probiotics in Health and Disease: Distinct Roles of Different Strains in Natural Killer Cell Activation and Regulation

Cited by 5 publications

References 0 publications

Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

Exploring the Potential of Natural Killer Cell-Based Immunotherapy in Targeting High-Grade Serous Ovarian Carcinomas

Immunotherapy: an alternative promising therapeutic approach against cancers

Supercharged NK Cell-Based Immuotherapy in Humanized Bone Marrow Liver and Thymus (Hu-BLT) Mice Model of Oral, Pancreatic, Glioblastoma, Hepatic, Melanoma and Ovarian Cancers

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