Probiotics in infants for prevention of allergic disease and food hypersensitivity

Osborn, David A; Sinn, John

doi:10.1002/14651858.cd006475.pub2

Cited by 236 publications

(223 citation statements)

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“…Nonetheless, their efficacy and tolerance has still not been proven (FAO/WHO, 2002;AFSSA, 2003;Agostoni et al, 2004Agostoni et al, , 2007Osborn and Sinn, 2007;Hol et al, 2008;Kopp et al, 2008;Lee et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

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Background/Objectives: To determine the impact of a not hydrolyzed fermented infant formula containing heat-killed Bifidobacterium breve C50 and Streptococcus thermophilus 065 (HKBBST) on the incidence of allergy-like events during the first 2 years of life in children at high risk of atopy. Subjects/Methods: This multicenter, randomized, double-blind, controlled study included infants at high risk of atopy. Infants used HKBBST or a standard infant formula (SIF) since birth until 1 year of age, and were followed at 4, 12 and 24 months after birth. Skin prick tests (SPTs) for six foods and six aeroallergens were systematically performed and adverse events (AEs) were recorded. In case of potentially allergic AE (PAAE), allergy could be further tested by SPT, patch tests and quantification of specific IgEs. If cow's milk allergy (CMA) was suspected, an oral challenge could also be performed. Results: The study included 129 children, 63 were randomized to SIF, 66 to HKBBST. The use of HKBBST milk did not alter the proportion of CMA but decreased the proportion of positive SPT to cow's milk (1.7 vs 12.5%, P ¼ 0.03), and the incidence of digestive (39 vs 63%, P ¼ 0.01) and respiratory potentially allergic AEs (7 vs 21%, P ¼ 0.03) at 12 months, and that of respiratory PAAEs at 24 months (13 vs 35%, P ¼ 0.01). Conclusions: HKBBST decreased the incidence of PAAEs in children with family history of atopy, during the first months of life and after the formula was stopped. Oral tolerance to cow's milk in infants at high risk of atopy may therefore be improved using not hydrolyzed fermented formulae.

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Section: Introductionmentioning

confidence: 99%

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

et al. 2010

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“…This was not the case with a mixture of B. breve M-16V and galacto-/fructooligosaccharide (Immunofortis) (van der Aa et al, 2010), even though this synbiotic mixture seemed to prevent asthma-like symptoms in infants with www.intechopen.com AD (van der Aa et al, 2011). To conclude, investigations of probiotics for the treatment of AD provide promising results, but are not conclusive, as confirmed by meta-analyzes (Lee et al, 2008;Osborn and Sinn, 2007) such that they do not provide sufficient basis to recommend the use of such products.…”

Section: Clinical Impact Of Probiotics In Atopic/allergic Diseases 4mentioning

confidence: 99%

Microbiota and Allergy: From Dysbiosis to Probiotics

Waligora‐Dupriet¹,

Butel²

2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…A different approach could be administration of live microorganisms, as has been attempted with probiotic and synbiotic preparations containing a small number of allegedly beneficial bacteria. Although these preparations are currently widely used, their benefit for allergic diseases (34) or for infant health in general (35) has not been clearly established. Moreover, a recent, large, placebo-controlled, randomized trial of the use of lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhea due to Clostridium difficile showed no benefit (36).…”

Section: Parker B Francis Lecturementioning

confidence: 99%

The Human Microbiome. Early Life Determinant of Health Outcomes

Martínez

2014

Annals ATS

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The development of new technologies to isolate and identify microbial genomes has markedly increased our understanding of the role of microbiomes in health and disease. The idea, first proposed as part of the hygiene hypothesis, that environmental microbes influence the developmental trajectories of the immune system in early life, has now been considerably extended and refined. The abundant microbiota present in mucosal surfaces, especially the gut, is actively selected by the host through complex receptor systems that respond differentially depending on the molecular patterns presented to mucosal cells. Germ-free mice are more likely to develop allergic airway inflammation and show alterations in normal motor control and anxiety. These effects can be reversed by neonatal microbial recolonization but remain unchanged if recolonization occurs in adults. What emerges from these recent studies is the discovery of a complex, major early environmental determinant of lifetime human phenotypes. To change the natural course of asthma, obesity, and other chronic inflammatory conditions, active manipulation of the extensive bacterial, phage, and fungal metagenomes present in mucosal surfaces may be required, specifically during the developing years. Domesticating the human microbiome and adapting it to our health needs may be a challenge akin to, but far more complex than, the one faced by humanity when a few dozen species of plants and animals were domesticated during the transition between huntergatherer and sedentary societies after the end of the Pleistocene era.

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Probiotics in infants for prevention of allergic disease and food hypersensitivity

Cited by 236 publications

References 73 publications

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

A non-hydrolyzed, fermented milk formula reduces digestive and respiratory events in infants at high risk of allergy

Microbiota and Allergy: From Dysbiosis to Probiotics

The Human Microbiome. Early Life Determinant of Health Outcomes

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