“…3389/fmicb.2024.1345684 Frontiers in Microbiology 04 frontiersin.org research has produced variable results as well. In some cases, probiotic supplements did not influence mood in healthy adults or individuals with irritable bowel syndrome, while other studies reported reduced depression scores in individuals with diagnosed depression and healthy adults, or decreased emotional reactivity (Desbonnet et al, 2008;Simrén et al, 2010;Messaoudi et al, 2011;Steenbergen et al, 2015;Akkasheh et al, 2016;Barrera-Bugueño et al, 2017;Kelly et al, 2017). A mixed outcome was observed in a study where anxiety scores were reduced but not depression scores, and mood improvement was evident only in those with low baseline mood (Benton et al, 2007;Rao et al, 2009).…”