Probiotics in Treatment of Allergic Rhinitis

Das, Rashmi Ranjan; Singh, Meenu; Shafiq, Nusrat

doi:10.1097/wox.0b013e3181f234d4

Cited by 30 publications

(22 citation statements)

References 24 publications

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“…Consequently, a consensus for or against the use of probiotics in AR has yet to be reached. Recent reviews have suggested that probiotics may have significant beneficial effects on AR management, with the potential to improve patient quality of life and reduce medication use . Additional randomized controlled trials (RCTs) have since been performed; however, differences in study parameters and individual probiotics used has made synthesis of this data very difficult.…”

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confidence: 99%

A systematic review and meta‐analysis of probiotics for the treatment of allergic rhinitis

Zajac

Adams

Turner

2015

Int Forum Allergy Rhinol

112

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Objective Probiotics have proven beneficial in a number of immune-mediated and allergic diseases. Several human studies have evaluated the efficacy of probiotics in allergic rhinitis, however, evidence for their use has yet to be firmly established. The current systematic review seeks to synthesize the results of available randomized trials. Study Design Systematic review and meta-analysis. Methods The Medline, EMBASE, and Cochrane Library databases were reviewed and randomized controlled trials were extracted based on defined inclusion criteria. The effect of probiotics on Rhinitis Quality of Life (RQLQ) scores, Rhinitis Total Symptom Scores (RTSS), as well as total and antigen-specific serum IgE levels were evaluated by meta-analysis. Results A total of 23 studies with 1919 patients were identified, including 21 double-blind randomized controlled trials and 2 randomized crossover studies. Multiple probiotic strains, study populations, and outcome measures were utilized in individual trials. Seventeen studies showed a significant clinical benefit from the use of probiotics in at least one outcome measure when compared to placebo, while 6 trials showed no benefit. Among the trials eligible for meta-analysis, the use of probiotics resulted in significant improvement in RQLQ scores compared to placebo [standard mean difference (SMD) −2.23; p = 0.02]. Probiotics had no effect on RTSS [SMD −0.36; p = 0.13] or total IgE levels [SMD 0.01; p = 0.94], while there was a trend toward a reduction in antigen-specific IgE [SMD 0.20; p = 0.06] in the placebo group compared to probiotic. Conclusions Probiotics may be beneficial in improving symptoms and quality of life in patients with allergic rhinitis, however, current evidence remains limited due to study heterogeneity and variable outcome measures. Additional high-quality studies are needed to establish appropriate recommendations.

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confidence: 99%

A systematic review and meta‐analysis of probiotics for the treatment of allergic rhinitis

Zajac

Adams

Turner

2015

Int Forum Allergy Rhinol

112

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“…In the systematic review [2], treatment with probiotic was shown to improve the quality of life score of patients with allergic rhinitis at the end of treatment. Other studies showing improvement with probiotic treatment decrease in the number of episodes of rhinitis per year.…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms of allergic rhinitis including rhinorrhea, nasal obstruction or blockage, nasal itching, sneezing, and postnasal drip reverse spontaneously or after treatment.Allergic rhinitis is a common chronic inflammatory disorder with an increasing trend of prevalence worldwide over the last few decades become a global health problem, affecting approximately 10 to 25% of the population [1]. Many of treatment modalities are employed to control the symptoms but there is no cure because they do not act through modification of inflammatory pathways which underlies the pathophysiologic basic of the disease [2]. Recently, in vitro experiments suggest that lactic acid bacteria (LAB) can inhibit Th2 cytokine production by mononuclear cells from patients with allergies [3].…”

Section: Introductionmentioning

confidence: 99%

The Effects of Probiotic Lactobacillus casei Shirota Strain in Patients with Allergic Rhinitis Symptoms

Widuri¹,

Suryani²

2015

IJPHS

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Article history:Received Aug 8, 2015 Revised Sep 21, 2015 Accepted Oct 23, 2015 Allergic rhinitis is inflammatory reactions mediated by immunoglobulin E, after exposure to allergens. Allergic rhinitis can be alleviated by the use of specific probiotics to confer immune effects. The specific strains used in this study were selected based on their anti-inflammatory properties and an expected in promoting a Th1 type of immune response. To review the benefits of probiotics of Lactobacillus casei in preventing allergy attacks which inhibit the production of IgE, IL-4 and in reducing the symptoms. The study design was quasi-experimental with pre and post test design. The subjects were 45 patients who had a history of allergic rhinitis and filled out the questionnaires to get the allergic symptoms. The blood samples were taken for examining the IgE and IL-4 levels then after giving milk containing probiotics for 1 month, the researcher did the same examination. The mean IgE and IL-4 levels decreased before and after probiotics supplementation from 291.88 IU /L and 22.48 pg/ml to 141.43 IU/L and 17.83 pg/ml. The result of the statistical analysis paired t-test test was p = 0.00 on IgE level and p=0,056 on IL-4 level. The allergic rhinitis symptoms decreased significantly, the patients who had persistent symptom reduced from 28 patients to 2 patients. Based on the Wilcoxon signed rank test showed a significance value of P = 0.00. Probiotics is useful in preventing allergy attacks that inhibit the production of IgE, IL-4 and reduces the symptoms.

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“…Although there was a decrease in episodes of rhinitis per year, there was no change in blood or immunological parameters and no effect on time free from rhinitis episodes or mean duration of episodes. [20] Similarly, a more recent systematic review and meta-analysis involving MEDLINE, Embase and Cochrane Library databases, found 21 double-blind randomised controlled trials and two rando mised crossover studies (N=1 919) involving multiple pro biotics, populations and outcomes. [21] Seventeen of these showed significant clinical benefit in one or more outcome measures; however, six showed no benefit.…”

Section: In Practicementioning

confidence: 99%

The microbiome in chronic inflammatory airway disease: A threatened species

et al. 2016

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Corresponding author: R J Green (robin.green@up.ac.za)The human body is exposed to a multitude of microbes and infectious organisms throughout life. Many of these organisms colonise the skin, gastrointestinal tract (GIT) and airway. We now recognise that this colonisation includes the lower airway, previously thought to be sterile. These colonising organisms play an important role in disease prevention, including an array of chronic inflammatory conditions that are unrelated to infectious diseases. However, new evidence of immune dysregulation suggests that early colonisation, especially of the GIT and airway, by pathogenic micro-organisms, has deleterious effects that may contribute to the potential to induce chronic inflammation in young children, which may only express itself in adult life.

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Probiotics in Treatment of Allergic Rhinitis

Cited by 30 publications

References 24 publications

A systematic review and meta‐analysis of probiotics for the treatment of allergic rhinitis

A systematic review and meta‐analysis of probiotics for the treatment of allergic rhinitis

The Effects of Probiotic Lactobacillus casei Shirota Strain in Patients with Allergic Rhinitis Symptoms

The microbiome in chronic inflammatory airway disease: A threatened species

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